Breastfeeding as an Exposure Pathway for Perfluorinated Alkylates
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Breastfeeding as an Exposure Pathway for Perfluorinated Alkylates. / Mogensen, Ulla B; Grandjean, Philippe; Nielsen, Flemming; Weihe, Pal; Budtz-Jørgensen, Esben.
I: Environmental Science & Technology (Washington), Bind 49, Nr. 17, 2015, s. 10466-10473.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Breastfeeding as an Exposure Pathway for Perfluorinated Alkylates
AU - Mogensen, Ulla B
AU - Grandjean, Philippe
AU - Nielsen, Flemming
AU - Weihe, Pal
AU - Budtz-Jørgensen, Esben
PY - 2015
Y1 - 2015
N2 - Perfluorinated alkylate substances (PFASs) are widely used and have resulted in human exposures worldwide. PFASs occur in breast milk, and the duration of breastfeeding is associated with serum-PFAS concentrations in children. To determine the time-dependent impact of this exposure pathway, we examined the serum concentrations of five major PFASs in a Faroese birth cohort at birth, and at ages 11, 18, and 60 months. Information about the children's breastfeeding history was obtained from the mothers. The trajectory of serum-PFAS concentrations during months with and without breastfeeding was examined by linear mixed models that accounted for the correlations of the PFAS measurements for each child. The models were adjusted for confounders such as body size. The duration of exclusive breastfeeding was associated with increases of most PFAS concentrations by up to 30% per month, with lower increases during partial breast-feeding. In contrast to this main pattern, perfluorohexanesulfonate was not affected by breast-feeding. After cessation of breastfeeding, all serum concentrations decreased. This finding supports the evidence of breastfeeding being an important exposure pathway to some PFASs in infants.
AB - Perfluorinated alkylate substances (PFASs) are widely used and have resulted in human exposures worldwide. PFASs occur in breast milk, and the duration of breastfeeding is associated with serum-PFAS concentrations in children. To determine the time-dependent impact of this exposure pathway, we examined the serum concentrations of five major PFASs in a Faroese birth cohort at birth, and at ages 11, 18, and 60 months. Information about the children's breastfeeding history was obtained from the mothers. The trajectory of serum-PFAS concentrations during months with and without breastfeeding was examined by linear mixed models that accounted for the correlations of the PFAS measurements for each child. The models were adjusted for confounders such as body size. The duration of exclusive breastfeeding was associated with increases of most PFAS concentrations by up to 30% per month, with lower increases during partial breast-feeding. In contrast to this main pattern, perfluorohexanesulfonate was not affected by breast-feeding. After cessation of breastfeeding, all serum concentrations decreased. This finding supports the evidence of breastfeeding being an important exposure pathway to some PFASs in infants.
KW - Alkylation
KW - Breast Feeding
KW - Child, Preschool
KW - Cohort Studies
KW - Environmental Exposure
KW - Female
KW - Fluorocarbons
KW - Humans
KW - Infant
KW - Male
U2 - 10.1021/acs.est.5b02237
DO - 10.1021/acs.est.5b02237
M3 - Journal article
C2 - 26291735
VL - 49
SP - 10466
EP - 10473
JO - Environmental Science & Technology
JF - Environmental Science & Technology
SN - 0013-936X
IS - 17
ER -
ID: 161882691