Body iron is a contributor to oxidative damage of DNA

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Body iron is a contributor to oxidative damage of DNA. / Tuomainen, T.P.; Loft, Steffen Huitfeldt; Nyyssonen, K.; Punnonen, K.; Salonen, J.T.; Poulsen, Henrik Enghusen; Tuomainen, Tomi-Pekka; Loft, Steffen; Nyyssönen, Kristiina; Punnonen, Kari; Salonen, Jukka T; Poulsen, Henrik E.

I: Free Radical Research, Bind 41, Nr. 3, 2007, s. 324-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Tuomainen, TP, Loft, SH, Nyyssonen, K, Punnonen, K, Salonen, JT, Poulsen, HE, Tuomainen, T-P, Loft, S, Nyyssönen, K, Punnonen, K, Salonen, JT & Poulsen, HE 2007, 'Body iron is a contributor to oxidative damage of DNA', Free Radical Research, bind 41, nr. 3, s. 324-8. https://doi.org/10.1080/10715760601091642

APA

Tuomainen, T. P., Loft, S. H., Nyyssonen, K., Punnonen, K., Salonen, J. T., Poulsen, H. E., Tuomainen, T-P., Loft, S., Nyyssönen, K., Punnonen, K., Salonen, J. T., & Poulsen, H. E. (2007). Body iron is a contributor to oxidative damage of DNA. Free Radical Research, 41(3), 324-8. https://doi.org/10.1080/10715760601091642

Vancouver

Tuomainen TP, Loft SH, Nyyssonen K, Punnonen K, Salonen JT, Poulsen HE o.a. Body iron is a contributor to oxidative damage of DNA. Free Radical Research. 2007;41(3):324-8. https://doi.org/10.1080/10715760601091642

Author

Tuomainen, T.P. ; Loft, Steffen Huitfeldt ; Nyyssonen, K. ; Punnonen, K. ; Salonen, J.T. ; Poulsen, Henrik Enghusen ; Tuomainen, Tomi-Pekka ; Loft, Steffen ; Nyyssönen, Kristiina ; Punnonen, Kari ; Salonen, Jukka T ; Poulsen, Henrik E. / Body iron is a contributor to oxidative damage of DNA. I: Free Radical Research. 2007 ; Bind 41, Nr. 3. s. 324-8.

Bibtex

@article{5b63c9e020ec11ddbc23000ea68e967b,
title = "Body iron is a contributor to oxidative damage of DNA",
abstract = "The transition metal iron is catalytically highly active in vitro, and not surprisingly, body iron has been suggested to promote oxidative stress in vivo. In the current analysis we studied the association of serum ferritin concentration and serum soluble transferrin receptor concentration with daily urinary 8-hydroxydeoxyguanosine excretion, a marker of oxidative stress, in 48 mildly dyslipidemic men in East Finland. In multivariate linear regression analyses allowing for age, smoking, body mass index and physical exercise, serum ferritin concentration predicted the excretion rate at B = 0.17 (95% CI 0.08-0.26, P = 0.001), and serum soluble transferrin receptor to ferritin concentration ratio (TfR/ferritin) predicted the excretion rate at B = - 0.13 (95% CI - 0.21 to - 0.05, P = 0.002). Our data suggest that body iron contributes to excess oxidative stress already at non-iron overload concentrations in these subjects.",
author = "T.P. Tuomainen and Loft, {Steffen Huitfeldt} and K. Nyyssonen and K. Punnonen and J.T. Salonen and Poulsen, {Henrik Enghusen} and Tomi-Pekka Tuomainen and Steffen Loft and Kristiina Nyyss{\"o}nen and Kari Punnonen and Salonen, {Jukka T} and Poulsen, {Henrik E}",
year = "2007",
doi = "http://dx.doi.org/10.1080/10715760601091642",
language = "English",
volume = "41",
pages = "324--8",
journal = "Free Radical Research",
issn = "1071-5762",
publisher = "Taylor & Francis",
number = "3",

}

RIS

TY - JOUR

T1 - Body iron is a contributor to oxidative damage of DNA

AU - Tuomainen, T.P.

AU - Loft, Steffen Huitfeldt

AU - Nyyssonen, K.

AU - Punnonen, K.

AU - Salonen, J.T.

AU - Poulsen, Henrik Enghusen

AU - Tuomainen, Tomi-Pekka

AU - Loft, Steffen

AU - Nyyssönen, Kristiina

AU - Punnonen, Kari

AU - Salonen, Jukka T

AU - Poulsen, Henrik E

PY - 2007

Y1 - 2007

N2 - The transition metal iron is catalytically highly active in vitro, and not surprisingly, body iron has been suggested to promote oxidative stress in vivo. In the current analysis we studied the association of serum ferritin concentration and serum soluble transferrin receptor concentration with daily urinary 8-hydroxydeoxyguanosine excretion, a marker of oxidative stress, in 48 mildly dyslipidemic men in East Finland. In multivariate linear regression analyses allowing for age, smoking, body mass index and physical exercise, serum ferritin concentration predicted the excretion rate at B = 0.17 (95% CI 0.08-0.26, P = 0.001), and serum soluble transferrin receptor to ferritin concentration ratio (TfR/ferritin) predicted the excretion rate at B = - 0.13 (95% CI - 0.21 to - 0.05, P = 0.002). Our data suggest that body iron contributes to excess oxidative stress already at non-iron overload concentrations in these subjects.

AB - The transition metal iron is catalytically highly active in vitro, and not surprisingly, body iron has been suggested to promote oxidative stress in vivo. In the current analysis we studied the association of serum ferritin concentration and serum soluble transferrin receptor concentration with daily urinary 8-hydroxydeoxyguanosine excretion, a marker of oxidative stress, in 48 mildly dyslipidemic men in East Finland. In multivariate linear regression analyses allowing for age, smoking, body mass index and physical exercise, serum ferritin concentration predicted the excretion rate at B = 0.17 (95% CI 0.08-0.26, P = 0.001), and serum soluble transferrin receptor to ferritin concentration ratio (TfR/ferritin) predicted the excretion rate at B = - 0.13 (95% CI - 0.21 to - 0.05, P = 0.002). Our data suggest that body iron contributes to excess oxidative stress already at non-iron overload concentrations in these subjects.

U2 - http://dx.doi.org/10.1080/10715760601091642

DO - http://dx.doi.org/10.1080/10715760601091642

M3 - Journal article

VL - 41

SP - 324

EP - 328

JO - Free Radical Research

JF - Free Radical Research

SN - 1071-5762

IS - 3

ER -

ID: 4043259