Anti-Müllerian hormone and live birth in unexplained recurrent pregnancy loss

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Anti-Müllerian hormone and live birth in unexplained recurrent pregnancy loss. / Bliddal, Sofie; Feldt-Rasmussen, Ulla; Forman, Julie Lyng; Hilsted, Linda Maria; Larsen, Elisabeth Clare; Christiansen, Ole Bjarne; Nielsen, Claus Henrik; Kolte, Astrid Marie; Nielsen, Henriette Svarre.

I: Reproductive BioMedicine Online, Bind 46, Nr. 6, 2023, s. 995-1003.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bliddal, S, Feldt-Rasmussen, U, Forman, JL, Hilsted, LM, Larsen, EC, Christiansen, OB, Nielsen, CH, Kolte, AM & Nielsen, HS 2023, 'Anti-Müllerian hormone and live birth in unexplained recurrent pregnancy loss', Reproductive BioMedicine Online, bind 46, nr. 6, s. 995-1003. https://doi.org/10.1016/j.rbmo.2023.01.023

APA

Bliddal, S., Feldt-Rasmussen, U., Forman, J. L., Hilsted, L. M., Larsen, E. C., Christiansen, O. B., Nielsen, C. H., Kolte, A. M., & Nielsen, H. S. (2023). Anti-Müllerian hormone and live birth in unexplained recurrent pregnancy loss. Reproductive BioMedicine Online, 46(6), 995-1003. https://doi.org/10.1016/j.rbmo.2023.01.023

Vancouver

Bliddal S, Feldt-Rasmussen U, Forman JL, Hilsted LM, Larsen EC, Christiansen OB o.a. Anti-Müllerian hormone and live birth in unexplained recurrent pregnancy loss. Reproductive BioMedicine Online. 2023;46(6):995-1003. https://doi.org/10.1016/j.rbmo.2023.01.023

Author

Bliddal, Sofie ; Feldt-Rasmussen, Ulla ; Forman, Julie Lyng ; Hilsted, Linda Maria ; Larsen, Elisabeth Clare ; Christiansen, Ole Bjarne ; Nielsen, Claus Henrik ; Kolte, Astrid Marie ; Nielsen, Henriette Svarre. / Anti-Müllerian hormone and live birth in unexplained recurrent pregnancy loss. I: Reproductive BioMedicine Online. 2023 ; Bind 46, Nr. 6. s. 995-1003.

Bibtex

@article{ff09c3323788449a8f36d6776feb33bf,

title = "Anti-M{\"u}llerian hormone and live birth in unexplained recurrent pregnancy loss",

abstract = "RESEARCH QUESTION: Is anti-M{\"u}llerian hormone (AMH) associated with live birth rate (LBR) in women with unexplained recurrent pregnancy loss (RPL)?DESIGN: Cohort study of women with unexplained RPL attending the RPL Unit, Copenhagen University Hospital, Denmark, between 2015 and 2021. AMH concentration was assessed upon referral, and LBR in the next pregnancy. RPL was defined as three or more consecutive pregnancy losses. Regression analyses were adjusted for age, number of previous losses, body mass index, smoking, treatment with assisted reproductive technology (ART) and RPL treatments.RESULTS: A total of 629 women were included; 507 (80.6%) became pregnant after referral. Pregnancy rates were similar for women with low and high AMH compared to women with medium AMH (81.9, 80.3 and 79.7%, respectively) (low AMH: adjusted odds ratio [aOR] 1.44, 95% confidence interval [CI] 0.84-2.47, P = 0.18; high AMH: aOR 0.98, 95% CI 0.59-1.64, P = 0.95). AMH concentrations were not associated with live birth. LBR was 59.5% in women with low AMH, 66.1% with medium AMH and 65.1% with high AMH (low AMH: aOR 0.68, 95% CI 0.41-1.11, P = 0.12, high AMH: aOR 0.96, 95% CI 0.59-1.56, P = 0.87). Live birth was lower in ART pregnancies (aOR 0.57, 95% CI 0.33-0.97, P = 0.04) and with higher numbers of previous losses (aOR 0.81, 95% CI 0.68-0.95, P = 0.01).CONCLUSION: In women with unexplained RPL, AMH was not associated with the chances of live birth in the next pregnancy. Screening for AMH in all women with RPL is not supported by current evidence. The chance of live birth among women with unexplained RPL achieving pregnancy by ART was low and needs to be confirmed and explored in future studies.",

keywords = "Pregnancy, Female, Humans, Live Birth, Anti-Mullerian Hormone, Cohort Studies, Abortion, Habitual/epidemiology, Pregnancy, Multiple, Pregnancy Rate, Retrospective Studies, Fertilization in Vitro",

author = "Sofie Bliddal and Ulla Feldt-Rasmussen and Forman, {Julie Lyng} and Hilsted, {Linda Maria} and Larsen, {Elisabeth Clare} and Christiansen, {Ole Bjarne} and Nielsen, {Claus Henrik} and Kolte, {Astrid Marie} and Nielsen, {Henriette Svarre}",

year = "2023",

doi = "10.1016/j.rbmo.2023.01.023",

language = "English",

volume = "46",

pages = "995--1003",

journal = "Reproductive BioMedicine Online",

issn = "1472-6483",

publisher = "Elsevier",

number = "6",

}

RIS

TY - JOUR

T1 - Anti-Müllerian hormone and live birth in unexplained recurrent pregnancy loss

AU - Bliddal, Sofie

AU - Feldt-Rasmussen, Ulla

AU - Forman, Julie Lyng

AU - Hilsted, Linda Maria

AU - Larsen, Elisabeth Clare

AU - Christiansen, Ole Bjarne

AU - Nielsen, Claus Henrik

AU - Kolte, Astrid Marie

AU - Nielsen, Henriette Svarre

PY - 2023

Y1 - 2023

N2 - RESEARCH QUESTION: Is anti-Müllerian hormone (AMH) associated with live birth rate (LBR) in women with unexplained recurrent pregnancy loss (RPL)?DESIGN: Cohort study of women with unexplained RPL attending the RPL Unit, Copenhagen University Hospital, Denmark, between 2015 and 2021. AMH concentration was assessed upon referral, and LBR in the next pregnancy. RPL was defined as three or more consecutive pregnancy losses. Regression analyses were adjusted for age, number of previous losses, body mass index, smoking, treatment with assisted reproductive technology (ART) and RPL treatments.RESULTS: A total of 629 women were included; 507 (80.6%) became pregnant after referral. Pregnancy rates were similar for women with low and high AMH compared to women with medium AMH (81.9, 80.3 and 79.7%, respectively) (low AMH: adjusted odds ratio [aOR] 1.44, 95% confidence interval [CI] 0.84-2.47, P = 0.18; high AMH: aOR 0.98, 95% CI 0.59-1.64, P = 0.95). AMH concentrations were not associated with live birth. LBR was 59.5% in women with low AMH, 66.1% with medium AMH and 65.1% with high AMH (low AMH: aOR 0.68, 95% CI 0.41-1.11, P = 0.12, high AMH: aOR 0.96, 95% CI 0.59-1.56, P = 0.87). Live birth was lower in ART pregnancies (aOR 0.57, 95% CI 0.33-0.97, P = 0.04) and with higher numbers of previous losses (aOR 0.81, 95% CI 0.68-0.95, P = 0.01).CONCLUSION: In women with unexplained RPL, AMH was not associated with the chances of live birth in the next pregnancy. Screening for AMH in all women with RPL is not supported by current evidence. The chance of live birth among women with unexplained RPL achieving pregnancy by ART was low and needs to be confirmed and explored in future studies.

AB - RESEARCH QUESTION: Is anti-Müllerian hormone (AMH) associated with live birth rate (LBR) in women with unexplained recurrent pregnancy loss (RPL)?DESIGN: Cohort study of women with unexplained RPL attending the RPL Unit, Copenhagen University Hospital, Denmark, between 2015 and 2021. AMH concentration was assessed upon referral, and LBR in the next pregnancy. RPL was defined as three or more consecutive pregnancy losses. Regression analyses were adjusted for age, number of previous losses, body mass index, smoking, treatment with assisted reproductive technology (ART) and RPL treatments.RESULTS: A total of 629 women were included; 507 (80.6%) became pregnant after referral. Pregnancy rates were similar for women with low and high AMH compared to women with medium AMH (81.9, 80.3 and 79.7%, respectively) (low AMH: adjusted odds ratio [aOR] 1.44, 95% confidence interval [CI] 0.84-2.47, P = 0.18; high AMH: aOR 0.98, 95% CI 0.59-1.64, P = 0.95). AMH concentrations were not associated with live birth. LBR was 59.5% in women with low AMH, 66.1% with medium AMH and 65.1% with high AMH (low AMH: aOR 0.68, 95% CI 0.41-1.11, P = 0.12, high AMH: aOR 0.96, 95% CI 0.59-1.56, P = 0.87). Live birth was lower in ART pregnancies (aOR 0.57, 95% CI 0.33-0.97, P = 0.04) and with higher numbers of previous losses (aOR 0.81, 95% CI 0.68-0.95, P = 0.01).CONCLUSION: In women with unexplained RPL, AMH was not associated with the chances of live birth in the next pregnancy. Screening for AMH in all women with RPL is not supported by current evidence. The chance of live birth among women with unexplained RPL achieving pregnancy by ART was low and needs to be confirmed and explored in future studies.

KW - Pregnancy

KW - Female

KW - Humans

KW - Live Birth

KW - Anti-Mullerian Hormone

KW - Cohort Studies

KW - Abortion, Habitual/epidemiology

KW - Pregnancy, Multiple

KW - Pregnancy Rate

KW - Retrospective Studies

KW - Fertilization in Vitro

U2 - 10.1016/j.rbmo.2023.01.023

DO - 10.1016/j.rbmo.2023.01.023

M3 - Journal article

C2 - 37055255

VL - 46

SP - 995

EP - 1003

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

SN - 1472-6483

IS - 6

ER -

ID: 358813267