AMH as Predictor of Premature Ovarian Insufficiency: A Longitudinal Study of 120 Turner Syndrome Patients

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Context: The majority of Turner syndrome (TS) patients suffer from accelerated loss of primordial follicles. Low circulating levels of anti-Müllerian hormone (AMH) may predict the lack of spontaneous puberty in prepubertal girls and imminent premature ovarian insufficiency (POI) in TS women with preserved ovarian function.
Objectives: To evaluate the association between circulating AMH and ovarian status in TS patients.
Design: Longitudinal observational cohort study.
Setting: Tertiary referral center for pediatric and gynecologic endocrinology.
Participants: A total of 120 TS patients, aged 0 to 48 years.
Main Outcome Measures: Longitudinal measurements of AMH, FSH, LH, estradiol, and inhibin B according to age, karyotype (45,X; 45,X/46,XX mosaicism; miscellaneous karyotypes), and ovarian status (group 0, prepubertal; group 1, never ovarian function; group 2, ongoing ovarian function; and group 3, loss of ovarian function).
Results: Ovarian status was highly associated with the TS karyotype: spontaneous puberty— 45,X (three of 44 patients), 45,X/46,XX (15 of 17), miscellaneous (17 of 42); and POI— 45,X (three of three), 45,X/46,XX (one of 15), and miscellaneous (eight of 17). AMH was associated with ovarian status (eg, group 1, 2 pmol/L; vs group 2, 19 pmol/L; P .001). AMH 4 pmol/L (corresponding to 2 SD) predicted absent puberty in prepubertal girls and POI in adolescent and adult patients.
Conclusion: The majority of women with mosaic karyotype 45,X/46,XX had ongoing ovarian function in early adulthood. AMH 2 SD predicted failure to enter puberty in young TS girls and imminent POI in adolescent and adult TS patients.
TidsskriftJournal of Clinical Endocrinology and Metabolism
Udgave nummer7
Sider (fra-til)E1030-8
Antal sider9
StatusUdgivet - jul. 2015

ID: 160446658