AMH as Predictor of Premature Ovarian Insufficiency: A Longitudinal Study of 120 Turner Syndrome Patients
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
AMH as Predictor of Premature Ovarian Insufficiency : A Longitudinal Study of 120 Turner Syndrome Patients. / Lunding, Stine Aa; Aksglæde, Lise; Anderson, Richard A; Main, Katharina M; Juul, Anders; Hagen, Casper P; Pedersen, Anette T.
I: Journal of Clinical Endocrinology and Metabolism, Bind 100, Nr. 7, 07.2015, s. E1030-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - AMH as Predictor of Premature Ovarian Insufficiency
T2 - A Longitudinal Study of 120 Turner Syndrome Patients
AU - Lunding, Stine Aa
AU - Aksglæde, Lise
AU - Anderson, Richard A
AU - Main, Katharina M
AU - Juul, Anders
AU - Hagen, Casper P
AU - Pedersen, Anette T
PY - 2015/7
Y1 - 2015/7
N2 - CONTEXT: The majority of Turner syndrome (TS) patients suffer from accelerated loss of primordial follicles. Low circulating levels of anti-Müllerian hormone (AMH) may predict the lack of spontaneous puberty in prepubertal girls and imminent premature ovarian insufficiency (POI) in TS women with preserved ovarian function.OBJECTIVES: To evaluate the association between circulating AMH and ovarian status in TS patients.DESIGN: Longitudinal observational cohort study.SETTING: Tertiary referral center for pediatric and gynecologic endocrinology.PARTICIPANTS: A total of 120 TS patients, aged 0 to 48 years.MAIN OUTCOME MEASURES: Longitudinal measurements of AMH, FSH, LH, estradiol, and inhibin B according to age, karyotype (45,X; 45,X/46,XX mosaicism; miscellaneous karyotypes), and ovarian status (group 0, prepubertal; group 1, never ovarian function; group 2, ongoing ovarian function; and group 3, loss of ovarian function).RESULTS: Ovarian status was highly associated with the TS karyotype: spontaneous puberty—45,X (three of 44 patients), 45,X/46,XX (15 of 17), miscellaneous (17 of 42); and POI—45,X (three of three), 45,X/46,XX (one of 15), and miscellaneous (eight of 17). AMH was associated with ovarian status (eg, group 1, <2 pmol/L; vs group 2, 19 pmol/L; P < .001). AMH < 4 pmol/L (corresponding to <-2 SD) predicted absent puberty in prepubertal girls and POI in adolescent and adult patients.CONCLUSION: The majority of women with mosaic karyotype 45,X/46,XX had ongoing ovarian function in early adulthood. AMH < -2 SD predicted failure to enter puberty in young TS girls and imminent POI in adolescent and adult TS patients.
AB - CONTEXT: The majority of Turner syndrome (TS) patients suffer from accelerated loss of primordial follicles. Low circulating levels of anti-Müllerian hormone (AMH) may predict the lack of spontaneous puberty in prepubertal girls and imminent premature ovarian insufficiency (POI) in TS women with preserved ovarian function.OBJECTIVES: To evaluate the association between circulating AMH and ovarian status in TS patients.DESIGN: Longitudinal observational cohort study.SETTING: Tertiary referral center for pediatric and gynecologic endocrinology.PARTICIPANTS: A total of 120 TS patients, aged 0 to 48 years.MAIN OUTCOME MEASURES: Longitudinal measurements of AMH, FSH, LH, estradiol, and inhibin B according to age, karyotype (45,X; 45,X/46,XX mosaicism; miscellaneous karyotypes), and ovarian status (group 0, prepubertal; group 1, never ovarian function; group 2, ongoing ovarian function; and group 3, loss of ovarian function).RESULTS: Ovarian status was highly associated with the TS karyotype: spontaneous puberty—45,X (three of 44 patients), 45,X/46,XX (15 of 17), miscellaneous (17 of 42); and POI—45,X (three of three), 45,X/46,XX (one of 15), and miscellaneous (eight of 17). AMH was associated with ovarian status (eg, group 1, <2 pmol/L; vs group 2, 19 pmol/L; P < .001). AMH < 4 pmol/L (corresponding to <-2 SD) predicted absent puberty in prepubertal girls and POI in adolescent and adult patients.CONCLUSION: The majority of women with mosaic karyotype 45,X/46,XX had ongoing ovarian function in early adulthood. AMH < -2 SD predicted failure to enter puberty in young TS girls and imminent POI in adolescent and adult TS patients.
KW - Adolescent
KW - Adult
KW - Anti-Mullerian Hormone
KW - Biomarkers
KW - Child
KW - Child, Preschool
KW - Female
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Longitudinal Studies
KW - Middle Aged
KW - Primary Ovarian Insufficiency
KW - Prognosis
KW - Turner Syndrome
KW - Young Adult
U2 - 10.1210/jc.2015-1621
DO - 10.1210/jc.2015-1621
M3 - Journal article
C2 - 25978111
VL - 100
SP - E1030-8
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 7
ER -
ID: 160446658