Pregnancy in women with MS: Impact on long-term disability accrual in a nationwide Danish Cohort
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Pregnancy in women with MS : Impact on long-term disability accrual in a nationwide Danish Cohort. / Andersen, Johanna Balslev; Wandall-Holm, Malthe Faurschou; Andersen, Per Kragh; Sellebjerg, Finn; Magyari, Melinda.
In: Multiple Sclerosis Journal, Vol. 28, No. 8, 2022, p. 1239-1247.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pregnancy in women with MS
T2 - Impact on long-term disability accrual in a nationwide Danish Cohort
AU - Andersen, Johanna Balslev
AU - Wandall-Holm, Malthe Faurschou
AU - Andersen, Per Kragh
AU - Sellebjerg, Finn
AU - Magyari, Melinda
N1 - Publisher Copyright: © The Author(s), 2021.
PY - 2022
Y1 - 2022
N2 - Background: Pregnancy is considered to influence the disease course in women with multiple sclerosis (MS). Objective: The aim of this study was to investigate the effect of pregnancy on long-term disability accrual in women with MS. Methods: The Danish Multiple Sclerosis Registry (DMSR) was used to identify women diagnosed with clinically isolated syndrome or relapsing-remitting MS. Cox models with pregnancy as a time-dependent exposure and propensity score (PS) models were used to evaluate time to reach confirmed Expanded Disability Status Scale (EDSS) score of 4 and 6. Results: A total of 425 women became parous and 840 remained nulliparous. When including pregnancy as a time-dependent exposure, a non-significant association with time to reach EDSS 4 (hazard ratio (HR) 0.86, 95% confidence interval (CI) 0.61–1.20) and EDSS 6 (HR 0.70, 95% CI 0.40–1.20) was found. Correspondingly, the PS model showed no association with pregnancy on time to reach EDSS 4 (HR 0.85, 95% CI 0.56–1.28). Conclusion: This study concludes that pregnancy does not affect long-term disability accumulation.
AB - Background: Pregnancy is considered to influence the disease course in women with multiple sclerosis (MS). Objective: The aim of this study was to investigate the effect of pregnancy on long-term disability accrual in women with MS. Methods: The Danish Multiple Sclerosis Registry (DMSR) was used to identify women diagnosed with clinically isolated syndrome or relapsing-remitting MS. Cox models with pregnancy as a time-dependent exposure and propensity score (PS) models were used to evaluate time to reach confirmed Expanded Disability Status Scale (EDSS) score of 4 and 6. Results: A total of 425 women became parous and 840 remained nulliparous. When including pregnancy as a time-dependent exposure, a non-significant association with time to reach EDSS 4 (hazard ratio (HR) 0.86, 95% confidence interval (CI) 0.61–1.20) and EDSS 6 (HR 0.70, 95% CI 0.40–1.20) was found. Correspondingly, the PS model showed no association with pregnancy on time to reach EDSS 4 (HR 0.85, 95% CI 0.56–1.28). Conclusion: This study concludes that pregnancy does not affect long-term disability accumulation.
KW - disability accumulation
KW - Multiple sclerosis
KW - pregnancy
U2 - 10.1177/13524585211057767
DO - 10.1177/13524585211057767
M3 - Journal article
C2 - 34791952
AN - SCOPUS:85119477469
VL - 28
SP - 1239
EP - 1247
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 8
ER -
ID: 325462620