Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent
Research output: Contribution to journal › Journal article › Research › peer-review
SCOPE: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption.
METHODS AND RESULTS: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10-7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3' of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10-8)such that each serving of low-fat dairy was associated with 0.225 kg m-2lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure.
CONCLUSION: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.
Original language | English |
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Article number | 1700347 |
Journal | Molecular Nutrition & Food Research |
Volume | 62 |
Issue number | 3 |
Pages (from-to) | 1-12 |
Number of pages | 12 |
ISSN | 1613-4125 |
DOIs | |
Publication status | Published - 2018 |
- Journal Article, genome-wide interaction study, dairy intake, body mass index, meta-analysis, CHARGE consortium
Research areas
Links
- http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5803424&blobtype=pdf
Accepted author manuscript
ID: 189863224