Theis Lange

Theis Lange

Head of Department, Professor


  1. 2022
  2. Published

    Association of Hypokalemia Incidence and Better Treatment Response in NSCLC Patients: A Meta-Analysis and Systematic Review on Anti-EGFR Targeted Therapy Clinical Trials

    Zhou, J., Bai, J., Yue, Y., Chen, X., Lange, Theis, You, D. & Zhao, Y., 2022, In: Frontiers in Oncology. 11, 11 p., 757456.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study

    You, D., Wang, D., Wu, Y., Chen, X., Shao, F., Wei, Y., Zhang, R., Lange, Theis, Ma, H., Xu, H., Hu, Z., Christiani, D. C., Shen, H., Chen, F. & Zhao, Y., 2022, In: BMC Medicine. 20, 1, 203.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Characteristics of Workplace Psychosocial Resources and Risk of Diabetes: A Prospective Cohort Study

    Xu, Tianwei, Clark, A. J., Pentti, J., Rugulies, Reiner Ernst, Lange, Theis, Vahtera, J., Magnusson Hanson, L. L., Westerlund, H., Kivimäki, M. & Rod, Naja Hulvej, 2022, In: Diabetes Care. Supplement. 45, 1, p. 59–66 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Choice of priors: how much scepticism is appropriate?

    Granholm, A., Munch, M. W., Møller, Morten Hylander, Lange, Theis & Perner, Anders, 2022, In: Intensive Care Medicine. 48, p. 372–373 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

  6. Published

    Clinical assessment as a part of an early warning score-a Danish cluster-randomised, multicentre study of an individual early warning score

    Nielsen, P. B., Langkjaer, C. S., Schultz, M., Kodal, A. M., Pedersen, N. E., Petersen, J. A., Lange, Theis, Arvig, Michael Dan, Meyhoff, Christian Sylvest, Bestle, Morten Heiberg, Hølge-Hazelton, B., Bunkenborg, G., Lippert, A., Andersen, Ove, Rasmussen, L. S. & Iversen, Kasper, 2022, In: Lancet digital health. 4, 7, p. E497-E506 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Conservative vs. liberal fluid therapy in septic shock - Protocol for secondary Bayesian analyses of the CLASSIC trial

    Sivapalan, P., Meyhoff, T. S., Hjortrup, P. B., Lange, Theis, Møller, Morten Hylander, Perner, Anders & Granholm, A., 2022, In: Acta Anaesthesiologica Scandinavica. 66, 6, p. 767-771 5 p.

    Research output: Contribution to journalReviewResearchpeer-review

  8. Published

    Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial

    Granholm, A., Munch, M. W., Myatra, S. N., Vijayaraghavan, B. K. T., Cronhjort, M., Wahlin, R. R., Jakob, S. M., Cioccari, L., Kjaer, M-B. N., Vesterlund, G. K., Meyhoff, T. S., Helleberg, M., Moller, M. H., Benfield, T., Venkatesh, B., Hammond, N. E., Micallef, S., Bassi, A., John, O., Jha, V. & 26 others, Kristiansen, Klaus Tjelle, Ulrik, Charlotte Suppli, Jorgensen, V. L., Smitt, M., Bestle, Morten Heiberg, Andreasen, Anne Sofie, Poulsen, L. M., Rasmussen, B. S., Brochner, A. C., Strom, T., Moller, A., Khan, M. S., Padmanaban, A., Divatia, J. V., Saseedharan, S., Borawake, K., Kapadia, F., Dixit, S., Chawla, R., Shukla, U., Amin, P., Chew, M. S., Wamberg, C. A., Gluud, C., Lange, Theis & Perner, Anders, 2022, In: Intensive Care Medicine. 48, p. 45–55 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Discrete-time survival analysis in the critically ill: a deep learning approach using heterogeneous data

    Thorsen-Meyer, H., Placido, Davide, Kaas-Hansen, Benjamin Skov, Nielsen, A. P., Lange, Theis, Nielsen, A. B., Toft, P., Schierbeck, J., Strøm, T., Chmura, Piotr Jaroslaw, Heimann, M., Belling, K., Perner, Anders & Brunak, Søren, 2022, In: npj Digital Medicine. 5, 10 p., 142.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Do sibling comparisons answer the causal question? In response to 'No causal associations between childhood family income and subsequent psychiatric disorders, substance misuse and violent crime arrests'

    Rod, Naja Hulvej, Lange, Theis & Petersen, Anne Helby, 2022, In: International Journal of Epidemiology. 51, 6, p. 2025–2026 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Goal directed fluid removal with furosemide versus placebo in intensive care patients with fluid overload: A trial protocol for a randomised, blinded trial (GODIF trial)

    Wichmann, S., Itenov, T. S., Berthelsen, R. E., Lange, T., Perner, A., Gluud, C., Lawson-Smith, P., Nebrich, L., Wiis, J., Brøchner, A. C., Hildebrandt, T., Behzadi, M. T., Strand, K., Andersen, F. H., Strøm, T., Järvisalo, M., Damgaard, K. A. J., Vang, M. L., Wahlin, R. R., Sigurdsson, M. I. & 4 others, Thormar, K. M., Ostermann, M., Keus, F. & Bestle, Morten Heiberg, 2022, In: Acta Anaesthesiologica Scandinavica. 66, 9, p. 1138-1145 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Haloperidol for the Treatment of Delirium in ICU Patients

    Andersen-Ranberg, N. C., Poulsen, L. M., Perner, A., Wetterslev, J., Estrup, S., Haestbacka, J., Morgan, M., Citerio, G., Caballero, J., Lange, T., Kjaer, M-B. N., Ebdrup, B. H., Engstrom, J., Olsen, M. H., Oxenboll Collet, M., Mortensen, C. B., Weber, S-O., Andreasen, A. S., Bestle, M. H., Uslu, B. & 28 others, Scharling Pedersen, H., Gramstrup Nielsen, L., Toft Boesen, H. C., Jensen, J. V., Nebrich, L., La Cour, K., Laigaard, J., Haurum, C., Olesen, M. W., Overgaard-Steensen, C., Westergaard, B., Brand, B. A., Kingo Vesterlund, G., Thornberg Kyhnauv, P., Mikkelsen, V. S., Hyttel-Sorensen, S., de Haas, I., Aagaard, S. R., Nielsen, L. O., Eriksen, A. S., Rasmussen, B. S., Brix, H., Hildebrandt, T., Schonemann-Lund, M., Fjeldsoe-Nielsen, H., Kuivalainen, A., Mathiesen, Ole & AID ICU Trial Grp, 2022, In: New England Journal of Medicine. 387, 20, p. 2425-2435 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Higher versus lower oxygenation targets in COVID-19 patients with severe hypoxaemia (HOT-COVID) trial: Protocol for a secondary Bayesian analysis

    Mølgaard Nielsen, F., Lass Klitgaard, T., Granholm, A., Lange, Theis, Perner, Anders, Lilleholt Schjørring, O. & Steen Rasmussen, B., 2022, In: Acta Anaesthesiologica Scandinavica. 66, 3, p. 408-414

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Incidence of Positive Severe Acute Respiratory Syndrome Coronavirus Polymerase Chain Reaction After Coronavirus Disease 2019 Vaccination With up to 8 Months of Follow-up: Real-life Data From the Capital Region of Denmark

    Heftdal, Line Dam, Schultz, M., Lange, Theis, Knudsen, A. D., Fogh, K., Hasselbalch, R. B., Linander, C. B., Kallemose, T., Bundgård, Henning, Grønbæk, Kirsten, Valentiner-Branth, P., Iversen, Kasper & Nielsen, Susanne Dam, 2022, In: Clinical Infectious Diseases. 75, 1, p. e675–e682 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Incidence of hospital contacts with acute kidney injury after initiation of second-generation antipsychotics in older adults: a Danish population-based cohort study

    Sharon, R., Lange, Theis, Aakjær, Mia, Brøgger Kristiansen, S., Houlind, Morten Baltzer & Andersen, Morten, 2022, In: European Journal of Clinical Pharmacology. 78, p. 1341–1349 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Interactions in clinical trials: Protocol and statistical analysis plan for an explorative study of four randomized ICU trials on use of pantoprazole, oxygenation targets, haloperidol and intravenous fluids

    Schjørring, O. L., Lange, Theis, Krag, M., Andersen-Ranberg, N. C., Meyhoff, T. S., Marker, S., Klitgaard, T. L., Estrup, S., Møller, Morten Hylander, Rasmussen, B. S., Poulsen, L. M. & Perner, Anders, 2022, In: Acta Anaesthesiologica Scandinavica. 66, 1, p. 156-162 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Long-term cognitive and pulmonary functions following a lower versus a higher oxygenation target in the HOT-ICU trial: protocol and statistical analysis plan

    Crescioli, E., Riis, J., Weinreich, U. M., Jensen , Jens-Ulrik Stæhr , Poulsen, L. M., Brøchner, A. C., Lange, Theis, Perner, Anders, Klitgaard, T. L., Schjørring, O. L. & Rasmussen, B. S., 2022, In: Acta Anaesthesiologica Scandinavica. 66, 2, p. 282-287 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia

    Crescioli, E., Klitgaard, T. L., Poulsen, L. M., Brand, B. A., Siegemund, M., Grøfte, T., Keus, F., Pedersen, U. G., Bäcklund, M., Karttunen, J., Morgan, M., Ciubotariu, A., Bunzel, A-M. G., Vestergaard, S. R., Jensen, N. M., Jensen, T. S., Kjær, M-B. N., Jensen, A. K. G., Lange, T., Wetterslev, J. & 3 others, Perner, Anders, Schjørring, O. L. & Rasmussen, B. S., 2022, In: Intensive Care Medicine. 48, 6, p. 714–722 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia

    Granholm, A., Kjær, M-B. N., Munch, M. W., Myatra, S. N., Vijayaraghavan, B. K. T., Cronhjort, M., Wahlin, R. R., Jakob, S. M., Cioccari, L., Vesterlund, G. K., Meyhoff, T. S., Helleberg, M., Møller, M. H., Benfield, T., Venkatesh, B., Hammond, N. E., Micallef, S., Bassi, A., John, O., Jha, V. & 29 others, Kristiansen, Klaus Tjelle, Ulrik, Charlotte Suppli, Jørgensen, V. L., Smitt, M., Bestle, Morten Heiberg, Andreasen, Anne Sofie, Poulsen, L. M., Rasmussen, B. S., Brochner, A. C., Strøm, T., Møller, A., Khan, M. S., Padmanaban, A., Divatia, J. V., Saseedharan, S., Borawake, K., Kapadia, F., Dixit, S., Chawla, R., Shukla, U., Amin, P., Chew, M. S., Wamberg, C. A., Bose, N., Shah, M. S., Darfelt, I. S., Gluud, C., Lange, Theis & Perner, Anders, 2022, In: Intensive Care Medicine. 48, 5, p. 580–589 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Lower versus higher oxygenation targets in critically ill patients with severe hypoxaemia: secondary Bayesian analysis to explore heterogeneous treatment effects in the Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU) trial

    Klitgaard, T. L., Schjørring, O. L., Lange, Theis, Møller, Morten Hylander, Perner, Anders, Rasmussen, B. S. & Granholm, A., 2022, In: British Journal of Anaesthesia. 128, 1, p. 55-64 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Mediation of the parental education gradient in early adult mortality by childhood adversity: a population-based cohort study of more than 1 million children

    Elsenburg, Leonie K., Rieckmann, Andreas, Nguyen, Tri-Long, Bengtsson, J., Nybo Andersen, Anne-Marie, Taylor-Robinson, D., Lange, Theis & Rod, Naja Hulvej, 2022, In: The Lancet Public Health. 7, 2, p. e146-e155 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Metabolic Obesity Phenotypes and Risk of Lung Cancer: A Prospective Cohort Study of 450,482 UK Biobank Participants

    Shao, F., Chen, Y., Xu, H., Chen, X., Zhou, J., Wu, Y., Tang, Y., Wang, Z., Zhang, R., Lange, Theis, Ma, H., Hu, Z., Shen, H., Christiani, D. C., Chen, F., Zhao, Y. & You, D., 2022, In: Nutrients. 14, 16, 14 p., 3370.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Oxygenation targets in ICU patients with COVID-19: a post-hoc sub-group analysis of the HOT-ICU trial

    Rasmussen, B. S., Klitgaard, T. L., Perner, A., Brand, B. A., Hildebrandt, T., Siegemund, M., Hollinger, A., Aagaard, S. R., Bestle, M. H., Marcussen, K. V., Brøchner, A. C., Sølling, C. G., Poulsen, L. M., Laake, J. H., Aslam, T. N., Bäcklund, M., Okkonen, M., Morgan, M., Sharman, M., Lange, T. & 2 others, Wetterslev, J. & Schjørring, O. L., 2022, In: Acta Anaesthesiologica Scandinavica. 66, 1, p. 76-84 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Prostacyclin in Mechanically Ventilated Patients with COVID-19 and Severe Endotheliopathy: A Multicenter, Randomized, Clinical Trial

    Johansson, P. I., Søe-Jensen, P., Bestle, Morten Heiberg, Clausen, N. E., Kristiansen, Klaus Tjelle, Lange, Theis, Stensballe, J. & Perner, Anders, 2022, In: American Journal of Respiratory and Critical Care Medicine. 205, 3, p. 324-329 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Proteomics to identify biological pathways and develop prediction models of coronary microvascular dysfunction in women with angina and no obstructive coronary artery disease

    Prescott, Eva, Bove, K., Suhrs, H. E., Bechsgaard, D. F., Lange, Theis, Schroder, J., Nielsen, R. L. & IPOWER Study Grp, I. S. G., 2022, In: European Heart Journal. 43, Supplement 2, p. 1132-1132 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  26. Published

    Restriction of Intravenous Fluid in ICU Patients with Septic Shock

    Meyhoff, T. S., Hjortrup, P. B., Wetterslev, J., Sivapalan, P., Laake, J. H., Cronhjort, M., Jakob, S. M., Cecconi, M., Nalos, M., Ostermann, M., Malbrain, M., Pettila, V., Møller, M. H., Kjaer, M-B. N., Lange, T., Overgaard-Steensen, C., Brand, B. A., Winther-Olesen, M., White, J. O., Quist, L. & 48 others, Westergaard, B., Jonsson, A. B., Hjortso, C. J. S., Meier, N., Jensen, T. S., Engstrom, J., Nebrich, L., Andersen-Ranberg, N. C., Jensen, J. V., Joseph, N. A., Poulsen, L. M., Herlov, L. S., Solling, C. G., Pedersen, S. K., Knudsen, K. K., Straarup, T. S., Vang, M. L., Bundgaard, H., Rasmussen, B. S., Aagaard, S. R., Hildebrandt, T., Russell, Lene, Bestle, Morten Heiberg, Schonemann-Lund, M., Brochner, A. C., Elvander, C. F., Hoffmann, S. K. L., Rasmussen, M. L., Martin, Y. K., Friberg, F. F., Seter, H., Aslam, T. N., Adnoy, S., Seidel, P., Strand, K., Johnstad, B., Joelsson-Alm, E., Christensen, J., Ahlstedt, C., Pfortmueller, C. A., Siegemund, M., Greco, M., Radej, J., Kriz, M., Gould, D. W., Rowan, K. M., Mouncey, P. R. & Perner, Anders, 2022, In: New England Journal of Medicine. 386, p. 2459-2470 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Risk of new-onset type 2 diabetes in antidepressant users: A population-based cohort study in Denmark

    Sharon, R., Andersen, Morten & Lange, Theis, 2022, In: Pharmacoepidemiology and Drug Safety. 31, p. 115-116 2 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  28. Published

    Socio-cognitive factors influencing access to HIV prevention services among people who inject drugs in Dar es Salaam, Tanzania: An integrated bio-behavioural survey

    Likindikoki, S. L., Meyrowitsch, Dan Wolf, Mizinduko, M. M., Ishungisa, A. M., Tersbøl, Britt Pinkowski, Leyna, G. H., Moen, K., Makyao, N., Lange, Theis, Leshabari, M. T. & Mmbaga, E. J., 2022, In: PLoS ONE. 17, 1, 17 p., 0261500.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Socioeconomic disparity in cardiovascular disease: Possible biological pathways based on a proteomic approach

    Shafi, B. H., Bøttcher, M., Ejupi, A., Jensen, G., Osler, Merete, Lange, Theis & Prescott, Eva, 2022, In: Atherosclerosis. 352, p. 62-68 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Statistical advising: Professional development opportunities for the biostatistician COMMENT

    LeBlanc, M., Rueegg, C. S., Bekiroglu, N., Esterhuizen, T. M., Fagerland, M. W., Falk, R. S., Froslie, K. F., Graf, E., Heinze, G., Held, U., Holst, R., Lange, Theis, Mazumdar, M., Myrberg, I. H., Posch, M., Sergeant, J. C., Vach, W., Vance, E. A., HaraldWeedon-Fekjaer & Zucknick, M., 2022, In: Statistics in Medicine. 41, 5, p. 847-859 13 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  31. Published

    Stringency of COVID-19 Containment Response Policies and Air Quality Changes: A Global Analysis across 1851 Cities: Environmental Science & Technology

    Zhang, Jiawei, Lim, Youn-Hee, Andersen, Zorana Jovanovic, Napolitano, George, Taghavi Shahri, S. M., So, Rina, Plucker, M., Danesh-Yazdi, M., Cole-Hunter, Thomas, Therming Jørgensen, J., Liu, S., Bergmann, Marie, Jayant Mehta, A., Mortensen, Laust Hvas, Requia, W., Lange, Theis, Loft, Steffen, Kuenzli, N., Schwartz, J. & Amini, H., 2022, In: Environmental Science and Technology. 56, 17, p. 12086–12096 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Testing for Drug-Related Infectious Diseases and Determinants among People Who Use Drugs in a Low-Resource Setting: A Respondent-Driven Cross-Sectional Survey

    Likindikoki, S. L., Mmbaga, E. J., Mizinduko, M., Alexander, M., Adams, L., Horsburgh Jr, R. J., Moen, K., Leyna, G., Lange, Theis, Tersbol, B. P., Leshabari, M. & Meyrowitsch, Dan Wolf, 2022, In: Tropical Medicine and Infectious Disease. 7, 9, 16 p., 213.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    The effect of prostacyclin infusion on markers of endothelial activation and damage in mechanically ventilated patients with SARS-CoV-2 infection

    Vigstedt, M., Søe-Jensen, P., Bestle, Morten Heiberg, Clausen, N. E., Kristiansen, Klaus Tjelle, Lange, Theis, Stensballe, J., Perner, Anders & Jo­hans­son, Pär In­ge­mar , 2022, In: Journal of Critical Care. 69, 154010.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The future of divorce support: Is "digital" enough in presence of conflict?

    Cipric, Ana, Hald, Gert Martin, Strizzi, Jenna Marie, Lange, Theis, Austin, D., Sander, S. & Øverup, Camilla Stine, 2022, In: Journal of Marital and Family Therapy. 48, 4, p. 1128-1146 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    The impact of childhood adversity on parenting stress is mediated by adult attachment and depressive symptoms

    Madsen, Eva Back, Smith-Nielsen, Johanne, Egmose, Ida, Lange, Theis & Væver, Mette Skovgaard, 2022, In: Scandinavian Journal of Psychology. 63, 1, p. 47-54 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    The metabolic signature of cardiovascular disease and arterial calcification in patients with chronic kidney disease

    Sørensen, I. M., Bisgaard, Line, Bjergfelt, S. S., Ballegaard, E. L., Biering-Sørensen, Tor, Landler, N. E., Pedersen, T. X., Kofoed, Klaus Fuglsang, Lange, Theis, Feldt-Rasmussen, Bo, Bro, S. & Christoffersen, Christina, 2022, In: Atherosclerosis. 350, p. 109-118 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Workplace psychosocial resources and risk of cardiovascular disease among employees: a multi-cohort study of 135 669 participants

    Xu, Tianwei, Rugulies, Reiner Ernst, Vahtera, J., Pentti, J., Mathisen, J., Lange, Theis, Clark, A. J., Hanson, L. L. M., Westerlund, H., Ervasti, J., Virtanen, M., Kivimäki, M. & Rod, Naja Hulvej, 2022, In: Scandinavian Journal of Work, Environment and Health. 48, 8, p. 621-631 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    adaptr: an R package for simulating and comparing adaptive clinical trials

    Granholm, A., Jensen, Aksel Karl Georg, Lange, Theis & Kaas-Hansen, Benjamin Skov, 2022, In: Journal of Open Source Software. 7, 72, 1 p., 4284.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 13745