Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort

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Standard

Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort. / Kristensen, Stine Gry; Wakimoto, Yu; Colmorn, Lotte Berdiin; Dueholm, Margit; Pors, Susanne Elisabeth; Macklon, Kirsten Tryde; Mamsen, Linn Salto; Nikiforov, Dmitry; Cadenas, Jesús; Greve, Vinnie Hornshøj; Bay Bjørn, Anne-Mette; Rosendahl, Mikkel; Pedersen, Anette Tønnes; Nyboe Andersen, Anders; Fedder, Jens; Ernst, Erik; Andersen, Claus Yding.

I: Fertility and Sterility, Bind 116, Nr. 4, 2021, s. 1098-1106.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kristensen, SG, Wakimoto, Y, Colmorn, LB, Dueholm, M, Pors, SE, Macklon, KT, Mamsen, LS, Nikiforov, D, Cadenas, J, Greve, VH, Bay Bjørn, A-M, Rosendahl, M, Pedersen, AT, Nyboe Andersen, A, Fedder, J, Ernst, E & Andersen, CY 2021, 'Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort', Fertility and Sterility, bind 116, nr. 4, s. 1098-1106. https://doi.org/10.1016/j.fertnstert.2021.05.096

APA

Kristensen, S. G., Wakimoto, Y., Colmorn, L. B., Dueholm, M., Pors, S. E., Macklon, K. T., Mamsen, L. S., Nikiforov, D., Cadenas, J., Greve, V. H., Bay Bjørn, A-M., Rosendahl, M., Pedersen, A. T., Nyboe Andersen, A., Fedder, J., Ernst, E., & Andersen, C. Y. (2021). Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort. Fertility and Sterility, 116(4), 1098-1106. https://doi.org/10.1016/j.fertnstert.2021.05.096

Vancouver

Kristensen SG, Wakimoto Y, Colmorn LB, Dueholm M, Pors SE, Macklon KT o.a. Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort. Fertility and Sterility. 2021;116(4):1098-1106. https://doi.org/10.1016/j.fertnstert.2021.05.096

Author

Kristensen, Stine Gry ; Wakimoto, Yu ; Colmorn, Lotte Berdiin ; Dueholm, Margit ; Pors, Susanne Elisabeth ; Macklon, Kirsten Tryde ; Mamsen, Linn Salto ; Nikiforov, Dmitry ; Cadenas, Jesús ; Greve, Vinnie Hornshøj ; Bay Bjørn, Anne-Mette ; Rosendahl, Mikkel ; Pedersen, Anette Tønnes ; Nyboe Andersen, Anders ; Fedder, Jens ; Ernst, Erik ; Andersen, Claus Yding. / Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort. I: Fertility and Sterility. 2021 ; Bind 116, Nr. 4. s. 1098-1106.

Bibtex

@article{014f6852648147bebc2208b9ec7fec6b,

title = "Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort",

abstract = "OBJECTIVE: To evaluate the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort.DESIGN: Retrospective cohort study.SETTING: University hospitals and fertility clinics.PATIENT(S): Ovarian tissue cryopreservation (OTC) was performed for 1,186 Danish girls and women from 1999-2020, of whom 117 subsequently underwent ovarian tissue transplantation (OTT). Subgroup 1 included 759 patients with a follow-up period of >5 years. Out of these, OTT rates were further analyzed for those patients who were alive and aged >24 years in July 2020 (subgroup 2; n = 554).INTERVENTION(S): OTC and OTT.MAIN OUTCOME MEASURE(S): OTT, death, donation of tissue.RESULT(S): In subgroup 1, 14% of the patients had undergone OTT, 18% had died, 9% had donated their tissue for research, and 59% still had their tissue stored. In subgroup 2, 19% had undergone OTT and for most diagnoses the OTT rates ranged from 15% to 22% with benign hematologic diseases having the highest OTT rate (35%). On the basis of the entire cohort, stratified age analysis indicated that women aged ≥30 years at OTC were more likely to return for OTT than women aged 18-29 years at OTC; mean storage times were 3.7 and 3.6 years, respectively. Only 4% of the girls aged <18 years at OTC had undergone OTT.CONCLUSION(S): The OTT rates depended on the diagnosis, age at OTC, and follow-up time. Specific criteria are needed for reporting and comparing OTT rates. Six out of 10 patients still had their cryopreserved tissue stored and longer follow-up is needed, especially for younger girls.",

keywords = "Adolescent, Adult, Cryopreservation/trends, Denmark, Female, Fertility, Fertility Preservation, Humans, Infertility, Female/diagnosis, Organ Transplantation/trends, Ovary/transplantation, Pregnancy, Primary Ovarian Insufficiency/etiology, Retrospective Studies, Risk Factors, Time Factors, Young Adult",

author = "Kristensen, {Stine Gry} and Yu Wakimoto and Colmorn, {Lotte Berdiin} and Margit Dueholm and Pors, {Susanne Elisabeth} and Macklon, {Kirsten Tryde} and Mamsen, {Linn Salto} and Dmitry Nikiforov and Jes{\'u}s Cadenas and Greve, {Vinnie Hornsh{\o}j} and {Bay Bj{\o}rn}, Anne-Mette and Mikkel Rosendahl and Pedersen, {Anette T{\o}nnes} and {Nyboe Andersen}, Anders and Jens Fedder and Erik Ernst and Andersen, {Claus Yding}",

year = "2021",

doi = "10.1016/j.fertnstert.2021.05.096",

language = "English",

volume = "116",

pages = "1098--1106",

journal = "Sexuality, Reproduction and Menopause",

issn = "1546-2501",

publisher = "Elsevier",

number = "4",

}

RIS

TY - JOUR

T1 - Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort

AU - Kristensen, Stine Gry

AU - Wakimoto, Yu

AU - Colmorn, Lotte Berdiin

AU - Dueholm, Margit

AU - Pors, Susanne Elisabeth

AU - Macklon, Kirsten Tryde

AU - Mamsen, Linn Salto

AU - Nikiforov, Dmitry

AU - Cadenas, Jesús

AU - Greve, Vinnie Hornshøj

AU - Bay Bjørn, Anne-Mette

AU - Rosendahl, Mikkel

AU - Pedersen, Anette Tønnes

AU - Nyboe Andersen, Anders

AU - Fedder, Jens

AU - Ernst, Erik

AU - Andersen, Claus Yding

PY - 2021

Y1 - 2021

N2 - OBJECTIVE: To evaluate the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort.DESIGN: Retrospective cohort study.SETTING: University hospitals and fertility clinics.PATIENT(S): Ovarian tissue cryopreservation (OTC) was performed for 1,186 Danish girls and women from 1999-2020, of whom 117 subsequently underwent ovarian tissue transplantation (OTT). Subgroup 1 included 759 patients with a follow-up period of >5 years. Out of these, OTT rates were further analyzed for those patients who were alive and aged >24 years in July 2020 (subgroup 2; n = 554).INTERVENTION(S): OTC and OTT.MAIN OUTCOME MEASURE(S): OTT, death, donation of tissue.RESULT(S): In subgroup 1, 14% of the patients had undergone OTT, 18% had died, 9% had donated their tissue for research, and 59% still had their tissue stored. In subgroup 2, 19% had undergone OTT and for most diagnoses the OTT rates ranged from 15% to 22% with benign hematologic diseases having the highest OTT rate (35%). On the basis of the entire cohort, stratified age analysis indicated that women aged ≥30 years at OTC were more likely to return for OTT than women aged 18-29 years at OTC; mean storage times were 3.7 and 3.6 years, respectively. Only 4% of the girls aged <18 years at OTC had undergone OTT.CONCLUSION(S): The OTT rates depended on the diagnosis, age at OTC, and follow-up time. Specific criteria are needed for reporting and comparing OTT rates. Six out of 10 patients still had their cryopreserved tissue stored and longer follow-up is needed, especially for younger girls.

AB - OBJECTIVE: To evaluate the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort.DESIGN: Retrospective cohort study.SETTING: University hospitals and fertility clinics.PATIENT(S): Ovarian tissue cryopreservation (OTC) was performed for 1,186 Danish girls and women from 1999-2020, of whom 117 subsequently underwent ovarian tissue transplantation (OTT). Subgroup 1 included 759 patients with a follow-up period of >5 years. Out of these, OTT rates were further analyzed for those patients who were alive and aged >24 years in July 2020 (subgroup 2; n = 554).INTERVENTION(S): OTC and OTT.MAIN OUTCOME MEASURE(S): OTT, death, donation of tissue.RESULT(S): In subgroup 1, 14% of the patients had undergone OTT, 18% had died, 9% had donated their tissue for research, and 59% still had their tissue stored. In subgroup 2, 19% had undergone OTT and for most diagnoses the OTT rates ranged from 15% to 22% with benign hematologic diseases having the highest OTT rate (35%). On the basis of the entire cohort, stratified age analysis indicated that women aged ≥30 years at OTC were more likely to return for OTT than women aged 18-29 years at OTC; mean storage times were 3.7 and 3.6 years, respectively. Only 4% of the girls aged <18 years at OTC had undergone OTT.CONCLUSION(S): The OTT rates depended on the diagnosis, age at OTC, and follow-up time. Specific criteria are needed for reporting and comparing OTT rates. Six out of 10 patients still had their cryopreserved tissue stored and longer follow-up is needed, especially for younger girls.

KW - Adolescent

KW - Adult

KW - Cryopreservation/trends

KW - Denmark

KW - Female

KW - Fertility

KW - Fertility Preservation

KW - Humans

KW - Infertility, Female/diagnosis

KW - Organ Transplantation/trends

KW - Ovary/transplantation

KW - Pregnancy

KW - Primary Ovarian Insufficiency/etiology

KW - Retrospective Studies

KW - Risk Factors

KW - Time Factors

KW - Young Adult

U2 - 10.1016/j.fertnstert.2021.05.096

DO - 10.1016/j.fertnstert.2021.05.096

M3 - Journal article

C2 - 34130800

VL - 116

SP - 1098

EP - 1106

JO - Sexuality, Reproduction and Menopause

JF - Sexuality, Reproduction and Menopause

SN - 1546-2501

IS - 4

ER -

ID: 288856662