Effects of chloroquine, mefloquine and quinine on natural killer cell activity in vitro. An analysis of the inhibitory mechanism

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Standard

Effects of chloroquine, mefloquine and quinine on natural killer cell activity in vitro. An analysis of the inhibitory mechanism. / Pedersen, B K; Bygbjerg, I C; Theander, T G; Andersen, B J.

I: Allergy. European Journal of Allergy and Clinical Immunology, Bind 41, Nr. 7, 1986, s. 537-42.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Pedersen, BK, Bygbjerg, IC, Theander, TG & Andersen, BJ 1986, 'Effects of chloroquine, mefloquine and quinine on natural killer cell activity in vitro. An analysis of the inhibitory mechanism', Allergy. European Journal of Allergy and Clinical Immunology, bind 41, nr. 7, s. 537-42.

APA

Pedersen, B. K., Bygbjerg, I. C., Theander, T. G., & Andersen, B. J. (1986). Effects of chloroquine, mefloquine and quinine on natural killer cell activity in vitro. An analysis of the inhibitory mechanism. Allergy. European Journal of Allergy and Clinical Immunology, 41(7), 537-42.

Vancouver

Pedersen BK, Bygbjerg IC, Theander TG, Andersen BJ. Effects of chloroquine, mefloquine and quinine on natural killer cell activity in vitro. An analysis of the inhibitory mechanism. Allergy. European Journal of Allergy and Clinical Immunology. 1986;41(7):537-42.

Author

Pedersen, B K ; Bygbjerg, I C ; Theander, T G ; Andersen, B J. / Effects of chloroquine, mefloquine and quinine on natural killer cell activity in vitro. An analysis of the inhibitory mechanism. I: Allergy. European Journal of Allergy and Clinical Immunology. 1986 ; Bind 41, Nr. 7. s. 537-42.

Bibtex

@article{73969d50a0dd11dd86a6000ea68e967b,
title = "Effects of chloroquine, mefloquine and quinine on natural killer cell activity in vitro. An analysis of the inhibitory mechanism",
abstract = "Natural killer (NK) cell activity against K 562 target cells was inhibited by pharmacological concentrations of chloroquine, mefloquine and quinine. The most potent were mefloquine and quinine. The drug-induced inhibition of the NK cell activity was abolished by addition of alpha-interferon (IF) or interleukin 2 (Il-2); preincubation of mononuclear cells with IF or Il-2 followed by addition of anti-malarial drugs decreased the inhibitory effects of the drugs. The drug-induced inhibition of the NK cell activity was not dependent on the presence of monocytes. Using monocyte depleted Percoll fractionated NK cell enriched populations in a single cell agarose assay, it was shown that the inhibitory effects of mefloquine, but not of chloroquine and quinine were due to an inhibition of the formation of effector/target cell conjugates.",
author = "Pedersen, {B K} and Bygbjerg, {I C} and Theander, {T G} and Andersen, {B J}",
note = "Keywords: Cell Adhesion; Chloroquine; Cytotoxicity, Immunologic; Humans; Immunity, Cellular; Immunity, Natural; Interferons; Interleukin-2; Killer Cells, Natural; Mefloquine; Quinine; Quinolines",
year = "1986",
language = "English",
volume = "41",
pages = "537--42",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley Online",
number = "7",

}

RIS

TY - JOUR

T1 - Effects of chloroquine, mefloquine and quinine on natural killer cell activity in vitro. An analysis of the inhibitory mechanism

AU - Pedersen, B K

AU - Bygbjerg, I C

AU - Theander, T G

AU - Andersen, B J

N1 - Keywords: Cell Adhesion; Chloroquine; Cytotoxicity, Immunologic; Humans; Immunity, Cellular; Immunity, Natural; Interferons; Interleukin-2; Killer Cells, Natural; Mefloquine; Quinine; Quinolines

PY - 1986

Y1 - 1986

N2 - Natural killer (NK) cell activity against K 562 target cells was inhibited by pharmacological concentrations of chloroquine, mefloquine and quinine. The most potent were mefloquine and quinine. The drug-induced inhibition of the NK cell activity was abolished by addition of alpha-interferon (IF) or interleukin 2 (Il-2); preincubation of mononuclear cells with IF or Il-2 followed by addition of anti-malarial drugs decreased the inhibitory effects of the drugs. The drug-induced inhibition of the NK cell activity was not dependent on the presence of monocytes. Using monocyte depleted Percoll fractionated NK cell enriched populations in a single cell agarose assay, it was shown that the inhibitory effects of mefloquine, but not of chloroquine and quinine were due to an inhibition of the formation of effector/target cell conjugates.

AB - Natural killer (NK) cell activity against K 562 target cells was inhibited by pharmacological concentrations of chloroquine, mefloquine and quinine. The most potent were mefloquine and quinine. The drug-induced inhibition of the NK cell activity was abolished by addition of alpha-interferon (IF) or interleukin 2 (Il-2); preincubation of mononuclear cells with IF or Il-2 followed by addition of anti-malarial drugs decreased the inhibitory effects of the drugs. The drug-induced inhibition of the NK cell activity was not dependent on the presence of monocytes. Using monocyte depleted Percoll fractionated NK cell enriched populations in a single cell agarose assay, it was shown that the inhibitory effects of mefloquine, but not of chloroquine and quinine were due to an inhibition of the formation of effector/target cell conjugates.

M3 - Journal article

C2 - 2431633

VL - 41

SP - 537

EP - 542

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 7

ER -

ID: 6767251