Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts. / Bogl, Leonie H; Jelenkovic, Aline; Vuoksimaa, Eero; Ahrenfeldt, Linda; Pietiläinen, Kirsi H; Stazi, Maria A; Fagnani, Corrado; D'Ippolito, Cristina; Hur, Yoon-Mi; Jeong, Hoe-Uk; Silberg, Judy L; Eaves, Lindon J; Maes, Hermine H; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Cutler, Tessa L; Kandler, Christian; Jang, Kerry L; Christensen, Kaare; Skytthe, Axel; Kyvik, Kirsten O; Cozen, Wendy; Hwang, Amie E; Mack, Thomas M; Derom, Catherine A; Vlietinck, Robert F; Nelson, Tracy L; Whitfield, Keith E; Corley, Robin P; Huibregtse, Brooke M; McAdams, Tom A; Eley, Thalia C; Gregory, Alice M; Krueger, Robert F; McGue, Matt; Pahlen, Shandell; Willemsen, Gonneke; Bartels, Meike; van Beijsterveldt, Toos C E M; Pang, Zengchang; Tan, Qihua; Zhang, Dongfeng; Martin, Nicholas G; Medland, Sarah E; Montgomery, Grant W; Hjelmborg, Jacob V B; Rebato, Esther; Swan, Gary E; Krasnow, Ruth; Busjahn, Andreas; Lichtenstein, Paul; Öncel, Sevgi Y; Aliev, Fazil; Baker, Laura A; Tuvblad, Catherine; Siribaddana, Sisira H; Hotopf, Matthew; Sumathipala, Athula; Rijsdijk, Fruhling; Magnusson, Patrik K E; Pedersen, Nancy L; Aslan, Anna K Dahl; Ordoñana, Juan R; Sánchez-Romera, Juan F; Colodro-Conde, Lucia; Duncan, Glen E; Buchwald, Dedra; Tarnoki, Adam D; Tarnoki, David L; Yokoyama, Yoshie; Hopper, John L; Loos, Ruth J F; Boomsma, Dorret I; Sørensen, Thorkild I A; Silventoinen, Karri; Kaprio, Jaakko.
I: Biology of Sex Differences, Bind 8, 14, 2017.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Does the sex of one's co-twin affect height and BMI in adulthood?
T2 - A study of dizygotic adult twins from 31 cohorts
AU - Bogl, Leonie H
AU - Jelenkovic, Aline
AU - Vuoksimaa, Eero
AU - Ahrenfeldt, Linda
AU - Pietiläinen, Kirsi H
AU - Stazi, Maria A
AU - Fagnani, Corrado
AU - D'Ippolito, Cristina
AU - Hur, Yoon-Mi
AU - Jeong, Hoe-Uk
AU - Silberg, Judy L
AU - Eaves, Lindon J
AU - Maes, Hermine H
AU - Bayasgalan, Gombojav
AU - Narandalai, Danshiitsoodol
AU - Cutler, Tessa L
AU - Kandler, Christian
AU - Jang, Kerry L
AU - Christensen, Kaare
AU - Skytthe, Axel
AU - Kyvik, Kirsten O
AU - Cozen, Wendy
AU - Hwang, Amie E
AU - Mack, Thomas M
AU - Derom, Catherine A
AU - Vlietinck, Robert F
AU - Nelson, Tracy L
AU - Whitfield, Keith E
AU - Corley, Robin P
AU - Huibregtse, Brooke M
AU - McAdams, Tom A
AU - Eley, Thalia C
AU - Gregory, Alice M
AU - Krueger, Robert F
AU - McGue, Matt
AU - Pahlen, Shandell
AU - Willemsen, Gonneke
AU - Bartels, Meike
AU - van Beijsterveldt, Toos C E M
AU - Pang, Zengchang
AU - Tan, Qihua
AU - Zhang, Dongfeng
AU - Martin, Nicholas G
AU - Medland, Sarah E
AU - Montgomery, Grant W
AU - Hjelmborg, Jacob V B
AU - Rebato, Esther
AU - Swan, Gary E
AU - Krasnow, Ruth
AU - Busjahn, Andreas
AU - Lichtenstein, Paul
AU - Öncel, Sevgi Y
AU - Aliev, Fazil
AU - Baker, Laura A
AU - Tuvblad, Catherine
AU - Siribaddana, Sisira H
AU - Hotopf, Matthew
AU - Sumathipala, Athula
AU - Rijsdijk, Fruhling
AU - Magnusson, Patrik K E
AU - Pedersen, Nancy L
AU - Aslan, Anna K Dahl
AU - Ordoñana, Juan R
AU - Sánchez-Romera, Juan F
AU - Colodro-Conde, Lucia
AU - Duncan, Glen E
AU - Buchwald, Dedra
AU - Tarnoki, Adam D
AU - Tarnoki, David L
AU - Yokoyama, Yoshie
AU - Hopper, John L
AU - Loos, Ruth J F
AU - Boomsma, Dorret I
AU - Sørensen, Thorkild I A
AU - Silventoinen, Karri
AU - Kaprio, Jaakko
PY - 2017
Y1 - 2017
N2 - BACKGROUND: The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on anthropometric traits, we compared mean height, body mass index (BMI), and the prevalence of being overweight or obese between men and women from OS and SS dizygotic twin pairs.METHODS: The data were derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) database, and included 68,494 SS and 53,808 OS dizygotic twin individuals above the age of 20 years from 31 twin cohorts representing 19 countries. Zygosity was determined by questionnaires or DNA genotyping depending on the study. Multiple regression and logistic regression models adjusted for cohort, age, and birth year with the twin type as a predictor were carried out to compare height and BMI in twins from OS pairs with those from SS pairs and to calculate the adjusted odds ratios and 95% confidence intervals for being overweight or obese.RESULTS: OS females were, on average, 0.31 cm (95% confidence interval (CI) 0.20, 0.41) taller than SS females. OS males were also, on average, taller than SS males, but this difference was only 0.14 cm (95% CI 0.02, 0.27). Mean BMI and the prevalence of overweight or obesity did not differ between males and females from SS and OS twin pairs. The statistically significant differences between OS and SS twins for height were small and appeared to reflect our large sample size rather than meaningful differences of public health relevance.CONCLUSIONS: We found no evidence to support the hypothesis that prenatal hormonal exposure or postnatal socialization (i.e., having grown up with a twin of the opposite sex) has a major impact on height and BMI in adulthood.
AB - BACKGROUND: The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on anthropometric traits, we compared mean height, body mass index (BMI), and the prevalence of being overweight or obese between men and women from OS and SS dizygotic twin pairs.METHODS: The data were derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) database, and included 68,494 SS and 53,808 OS dizygotic twin individuals above the age of 20 years from 31 twin cohorts representing 19 countries. Zygosity was determined by questionnaires or DNA genotyping depending on the study. Multiple regression and logistic regression models adjusted for cohort, age, and birth year with the twin type as a predictor were carried out to compare height and BMI in twins from OS pairs with those from SS pairs and to calculate the adjusted odds ratios and 95% confidence intervals for being overweight or obese.RESULTS: OS females were, on average, 0.31 cm (95% confidence interval (CI) 0.20, 0.41) taller than SS females. OS males were also, on average, taller than SS males, but this difference was only 0.14 cm (95% CI 0.02, 0.27). Mean BMI and the prevalence of overweight or obesity did not differ between males and females from SS and OS twin pairs. The statistically significant differences between OS and SS twins for height were small and appeared to reflect our large sample size rather than meaningful differences of public health relevance.CONCLUSIONS: We found no evidence to support the hypothesis that prenatal hormonal exposure or postnatal socialization (i.e., having grown up with a twin of the opposite sex) has a major impact on height and BMI in adulthood.
KW - Journal Article
U2 - 10.1186/s13293-017-0134-x
DO - 10.1186/s13293-017-0134-x
M3 - Journal article
C2 - 28465822
VL - 8
JO - Biology of Sex Differences
JF - Biology of Sex Differences
SN - 2042-6410
M1 - 14
ER -
ID: 182972408