Development of a one-step probe based molecular assay for rapid immunodiagnosis of infection with M. Tuberculosisusing dried blood spots

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Development of a one-step probe based molecular assay for rapid immunodiagnosis of infection with M. Tuberculosisusing dried blood spots
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Thomas Blauenfeldt
Jan Heyckendorf
Sidse Graff Jensen
Christoph Lange
Camilla Drabe
Thomas S. Hermansen
Lena De Thurah
Lillebæk, Troels
Jesper Eugen-Olsen
Niels Seersholm
Søren Hoff
Jesper Bonde
Morten Ruhwald

Background: Antigen specific release of IP-10 is the most promising alternative marker to IFN-γ for infection with M. tuberculosis. Compared to Interferon-γ release assays (IGRA), IP-10 is released in high levels enabling novel approaches such as field friendly dried blood spots (DBS) and molecular detection.

Originalsprog	Engelsk
Artikelnummer	e105628
Tidsskrift	PLoS ONE
Vol/bind	9
Udgave nummer	9
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0105628
Status	Udgivet - 3 sep. 2014
Eksternt udgivet	Ja

ID: 247163747