Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians

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E Skjelbo
T K Mutabingwa
Bygbjerg, Ib Christian
K K Nielsen
L F Gram
K Brøosen

S-Mephenytoin and chloroguanide (proguanil) oxidation was studied in 216 tanzanians. The mephenytoin S/R ratio in urine ranged from 0.9, were arbitrarily defined as poor metabolizers of mephenytoin. The chloroguanide/cycloguanil ratio ranged from 0.82 to 249. There was a significant correlation between the mephenytoin S/R ratio and the chloroguanide/cycloguanil ratios (rs = 0.73; p

Originalsprog	Engelsk
Tidsskrift	Clinical Pharmacology and Therapeutics
Vol/bind	59
Udgave nummer	3
Sider (fra-til)	304-11
Antal sider	8
ISSN	0009-9236
DOI	https://doi.org/10.1016/S0009-9236(96)80008-7
Status	Udgivet - 1 mar. 1996

ID: 33890673