Vitamin D status and chronic obstructive pulmonary disease: a prospective general population study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
Standard
Vitamin D status and chronic obstructive pulmonary disease : a prospective general population study. / Skaaby, Tea; Husemoen, Lise Lotte Nystrup; Thuesen, Betina Heinsbæk; Pisinger, Charlotta; Jørgensen, Torben; Fenger, Runa Vavia; Linneberg, Allan.
I: PloS one, Bind 9, Nr. 3, e90654, 2014, s. 1-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Vitamin D status and chronic obstructive pulmonary disease
T2 - a prospective general population study
AU - Skaaby, Tea
AU - Husemoen, Lise Lotte Nystrup
AU - Thuesen, Betina Heinsbæk
AU - Pisinger, Charlotta
AU - Jørgensen, Torben
AU - Fenger, Runa Vavia
AU - Linneberg, Allan
PY - 2014
Y1 - 2014
N2 - OBJECTIVES: Vitamin D deficiency is common among persons with chronic obstructive pulmonary disease (COPD). Whether vitamin D affects the development and deterioration of COPD or is a consequence of the disease lacks clarity. We investigated the association between vitamin D status and prevalent and incident COPD in the general population.METHODS: We included a total of 12,041 individuals from three general population studies conducted in 1993-94, 1999-2001, and 2006-2008, respectively, with vitamin D measurements. Information on COPD was obtained from the Danish National Patient Register and The Danish Registry of Causes of Death.RESULTS: There were 85 prevalent and 463 incident cases of COPD (median follow-up 9.7 years). We found a statistically significant inverse association between vitamin D status and prevalent COPD with odds ratio = 0.89 (95% confidence interval, CI: 0.79, 1.0), but no statistically significant association with incident COPD with a hazard ratio = 0.98 (95% CI: 0.94, 1.0), respectively, per 10 nmol/l higher vitamin D status, when adjusted for possible confounders.CONCLUSIONS: We found a statistically significant inverse cross-sectional association between vitamin D status and COPD, but no association between vitamin D status and incident COPD.
AB - OBJECTIVES: Vitamin D deficiency is common among persons with chronic obstructive pulmonary disease (COPD). Whether vitamin D affects the development and deterioration of COPD or is a consequence of the disease lacks clarity. We investigated the association between vitamin D status and prevalent and incident COPD in the general population.METHODS: We included a total of 12,041 individuals from three general population studies conducted in 1993-94, 1999-2001, and 2006-2008, respectively, with vitamin D measurements. Information on COPD was obtained from the Danish National Patient Register and The Danish Registry of Causes of Death.RESULTS: There were 85 prevalent and 463 incident cases of COPD (median follow-up 9.7 years). We found a statistically significant inverse association between vitamin D status and prevalent COPD with odds ratio = 0.89 (95% confidence interval, CI: 0.79, 1.0), but no statistically significant association with incident COPD with a hazard ratio = 0.98 (95% CI: 0.94, 1.0), respectively, per 10 nmol/l higher vitamin D status, when adjusted for possible confounders.CONCLUSIONS: We found a statistically significant inverse cross-sectional association between vitamin D status and COPD, but no association between vitamin D status and incident COPD.
KW - Adolescent
KW - Adult
KW - Aged
KW - Cross-Sectional Studies
KW - Denmark
KW - Female
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Proportional Hazards Models
KW - Prospective Studies
KW - Pulmonary Disease, Chronic Obstructive
KW - Risk Factors
KW - Vitamin D
KW - Vitamin D Deficiency
KW - Young Adult
U2 - 10.1371/journal.pone.0090654
DO - 10.1371/journal.pone.0090654
M3 - Journal article
C2 - 24594696
VL - 9
SP - 1
EP - 8
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 3
M1 - e90654
ER -
ID: 137511897