The distribution of blood group antigens in experimentally produced carcinomas of rat palate

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The distribution of blood group antigens in experimentally produced carcinomas of rat palate. / Reibel, J; Philipsen, H P; Fisker, A V; Dabelsteen, Erik.

I: Journal of Oral Pathology, Bind 15, Nr. 10, 11.1986, s. 547-51.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Reibel, J, Philipsen, HP, Fisker, AV & Dabelsteen, E 1986, 'The distribution of blood group antigens in experimentally produced carcinomas of rat palate', Journal of Oral Pathology, bind 15, nr. 10, s. 547-51.

APA

Reibel, J., Philipsen, H. P., Fisker, A. V., & Dabelsteen, E. (1986). The distribution of blood group antigens in experimentally produced carcinomas of rat palate. Journal of Oral Pathology, 15(10), 547-51.

Vancouver

Reibel J, Philipsen HP, Fisker AV, Dabelsteen E. The distribution of blood group antigens in experimentally produced carcinomas of rat palate. Journal of Oral Pathology. 1986 nov.;15(10):547-51.

Author

Reibel, J ; Philipsen, H P ; Fisker, A V ; Dabelsteen, Erik. / The distribution of blood group antigens in experimentally produced carcinomas of rat palate. I: Journal of Oral Pathology. 1986 ; Bind 15, Nr. 10. s. 547-51.

Bibtex

@article{d929eb21f6ed47ca93c7310aac4a5bed,
title = "The distribution of blood group antigens in experimentally produced carcinomas of rat palate",
abstract = "It has been shown previously that rat oral epithelia express antigens cross-reacting with antibodies against human blood group antigen B and its structural precursor, the H antigen (Type 2 chain). In the present study we investigated the expression of these antigens in malignant changes in the rat palate induced by a chemical carcinogen (4NQO). The H antigen, normally expressed on spinous cells in rats, was absent in malignant epithelium, whereas staining for the B antigen, normally expressed on basal cells, was variable. These changes are equivalent to those seen in human squamous cell carcinomas. The blood group antigen staining pattern in experimentally produced verrucous carcinomas showed an almost normal blood group antigen expression. This may have diagnostic significance. Localized areas of hyperplastic palatal epithelium with slight dysplasia revealed loss of H antigen and the presence of B antigen in suprabasal strata equivalent to the pattern seen in human premalignant epithelium. We conclude from these findings, that the rat model is well suited to study changes in cell surface carbohydrates during chemical carcinogenesis.",
keywords = "4-Nitroquinoline-1-oxide, ABO Blood-Group System, Animals, Carcinoma, Papillary, Carcinoma, Squamous Cell, Disease Models, Animal, Immunologic Techniques, Palatal Neoplasms, Rats",
author = "J Reibel and Philipsen, {H P} and Fisker, {A V} and Erik Dabelsteen",
year = "1986",
month = nov,
language = "English",
volume = "15",
pages = "547--51",
journal = "Journal of Oral Pathology",
issn = "0300-9777",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - The distribution of blood group antigens in experimentally produced carcinomas of rat palate

AU - Reibel, J

AU - Philipsen, H P

AU - Fisker, A V

AU - Dabelsteen, Erik

PY - 1986/11

Y1 - 1986/11

N2 - It has been shown previously that rat oral epithelia express antigens cross-reacting with antibodies against human blood group antigen B and its structural precursor, the H antigen (Type 2 chain). In the present study we investigated the expression of these antigens in malignant changes in the rat palate induced by a chemical carcinogen (4NQO). The H antigen, normally expressed on spinous cells in rats, was absent in malignant epithelium, whereas staining for the B antigen, normally expressed on basal cells, was variable. These changes are equivalent to those seen in human squamous cell carcinomas. The blood group antigen staining pattern in experimentally produced verrucous carcinomas showed an almost normal blood group antigen expression. This may have diagnostic significance. Localized areas of hyperplastic palatal epithelium with slight dysplasia revealed loss of H antigen and the presence of B antigen in suprabasal strata equivalent to the pattern seen in human premalignant epithelium. We conclude from these findings, that the rat model is well suited to study changes in cell surface carbohydrates during chemical carcinogenesis.

AB - It has been shown previously that rat oral epithelia express antigens cross-reacting with antibodies against human blood group antigen B and its structural precursor, the H antigen (Type 2 chain). In the present study we investigated the expression of these antigens in malignant changes in the rat palate induced by a chemical carcinogen (4NQO). The H antigen, normally expressed on spinous cells in rats, was absent in malignant epithelium, whereas staining for the B antigen, normally expressed on basal cells, was variable. These changes are equivalent to those seen in human squamous cell carcinomas. The blood group antigen staining pattern in experimentally produced verrucous carcinomas showed an almost normal blood group antigen expression. This may have diagnostic significance. Localized areas of hyperplastic palatal epithelium with slight dysplasia revealed loss of H antigen and the presence of B antigen in suprabasal strata equivalent to the pattern seen in human premalignant epithelium. We conclude from these findings, that the rat model is well suited to study changes in cell surface carbohydrates during chemical carcinogenesis.

KW - 4-Nitroquinoline-1-oxide

KW - ABO Blood-Group System

KW - Animals

KW - Carcinoma, Papillary

KW - Carcinoma, Squamous Cell

KW - Disease Models, Animal

KW - Immunologic Techniques

KW - Palatal Neoplasms

KW - Rats

M3 - Journal article

C2 - 3104563

VL - 15

SP - 547

EP - 551

JO - Journal of Oral Pathology

JF - Journal of Oral Pathology

SN - 0300-9777

IS - 10

ER -

ID: 119594345