Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Sílvia Bonàs-Guarch
  • Marta Guindo-Martínez
  • Irene Miguel-Escalada
  • David Sebastian
  • Elias Rodriguez-Fos
  • Friman Sánchez
  • Mercè Planas-Fèlix
  • Paula Cortes-Sánchez
  • Santi González
  • Claire C Morgan
  • Ignasi Moran
  • Goutham Atla
  • Juan R González
  • Montserrat Puiggros
  • Jonathan Martí
  • Ehm A Andersson
  • Carlos Díaz
  • Rosa M Badia
  • Miriam Udler
  • Aaron Leong
  • Varindepal Kaur
  • Jason Flannick
  • Torben Jørgensen
  • Marit E Jørgensen
  • Daniel R Witte
  • Cramer Christensen
  • Ivan Brandslund
  • Emil V Appel
  • Robert A Scott
  • Jian'an Luan
  • Claudia Langenberg
  • Nicholas J Wareham
  • Antonio Zorzano
  • Jose C Florez
  • Jorge Ferrer
  • Josep Maria Mercader
  • David Torrents

The reanalysis of existing GWAS data represents a powerful and cost-effective opportunity to gain insights into the genetics of complex diseases. By reanalyzing publicly available type 2 diabetes (T2D) genome-wide association studies (GWAS) data for 70,127 subjects, we identify seven novel associated regions, five driven by common variants (LYPLAL1, NEUROG3, CAMKK2, ABO, and GIP genes), one by a low-frequency (EHMT2), and one driven by a rare variant in chromosome Xq23, rs146662057, associated with a twofold increased risk for T2D in males. rs146662057 is located within an active enhancer associated with the expression of Angiotensin II Receptor type 2 gene (AGTR2), a modulator of insulin sensitivity, and exhibits allelic specific activity in muscle cells. Beyond providing insights into the genetics and pathophysiology of T2D, these results also underscore the value of reanalyzing publicly available data using novel genetic resources and analytical approaches.

OriginalsprogEngelsk
Artikelnummer321
TidsskriftNature Communications
Vol/bind9
Antal sider14
ISSN2041-1723
DOI
StatusUdgivet - 22 jan. 2018

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