Myogenic, matrix and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding
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Myogenic, matrix and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding. / Agergaard, Jakob; Reitelseder, Søren; Pedersen, T.G.; Doessing, Simon; Schjerling, Peter; Langberg, Henning; Miller, Benjamin F; Aagaard, P; Kjær, Michael; Holm, Lars.
I: Muscle & Nerve, Bind 47, Nr. 5, 20.03.2013, s. 748-759.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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T1 - Myogenic, matrix and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding
AU - Agergaard, Jakob
AU - Reitelseder, Søren
AU - Pedersen, T.G.
AU - Doessing, Simon
AU - Schjerling, Peter
AU - Langberg, Henning
AU - Miller, Benjamin F
AU - Aagaard, P
AU - Kjær, Michael
AU - Holm, Lars
PY - 2013/3/20
Y1 - 2013/3/20
N2 - INTRODUCTION: We examined short-term (3-hour) and long-term (12-week) training effects after heavy load [HL; 70% 1RM] and light load (LL; 16% 1RM) exercise. METHODS: mRNA expression of genes involved in skeletal muscle remodeling were analyzed and muscle activity (EMG measurements) was measured. RESULTS: Relative muscle activity differed between HL and LL resistance exercise, whereas median power frequency was even, suggesting an equal muscle-fiber-type recruitment distribution. mRNA expression of Myf6, myogenin, and p21 was mostly increased, and myostatin was mostly depressed by HL resistance exercise. No major differences were seen in atrophy-related genes between HL and LL resistance exercise. No changes were seen over 12-week training for any of the targets. CONCLUSIONS: Resistance exercise at LL and HL elevated the expression of genes involved in skeletal muscle hypertrophy, although the greatest response was from HL. However, no long-term effect from either LL or HL resistance exercise was seen on basal levels of the mRNA targets.
AB - INTRODUCTION: We examined short-term (3-hour) and long-term (12-week) training effects after heavy load [HL; 70% 1RM] and light load (LL; 16% 1RM) exercise. METHODS: mRNA expression of genes involved in skeletal muscle remodeling were analyzed and muscle activity (EMG measurements) was measured. RESULTS: Relative muscle activity differed between HL and LL resistance exercise, whereas median power frequency was even, suggesting an equal muscle-fiber-type recruitment distribution. mRNA expression of Myf6, myogenin, and p21 was mostly increased, and myostatin was mostly depressed by HL resistance exercise. No major differences were seen in atrophy-related genes between HL and LL resistance exercise. No changes were seen over 12-week training for any of the targets. CONCLUSIONS: Resistance exercise at LL and HL elevated the expression of genes involved in skeletal muscle hypertrophy, although the greatest response was from HL. However, no long-term effect from either LL or HL resistance exercise was seen on basal levels of the mRNA targets.
U2 - 10.1002/mus.23667
DO - 10.1002/mus.23667
M3 - Journal article
VL - 47
SP - 748
EP - 759
JO - Muscle & Nerve
JF - Muscle & Nerve
SN - 0148-639X
IS - 5
ER -
ID: 129774691