Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring
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Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring. / Søegaard, Signe Holst; Rostgaard, Klaus; Kamper-Jørgensen, Mads; Schmiegelow, Kjeld; Hjalgrim, Henrik.
I: British Journal of Cancer, Bind 118, Nr. 1, 2018, s. 117-120.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring
AU - Søegaard, Signe Holst
AU - Rostgaard, Klaus
AU - Kamper-Jørgensen, Mads
AU - Schmiegelow, Kjeld
AU - Hjalgrim, Henrik
PY - 2018
Y1 - 2018
N2 - BACKGROUND: Maternal diabetes may be linked to childhood acute lymphoblastic leukaemia (ALL) in the offspring.METHODS: We assessed the association between maternal pregestational or gestational diabetes and offspring risk of childhood ALL in a register-based study, including all singletons born in Denmark during 1996-2015 (n=1 187 482).RESULTS: Adjusted hazard ratios of childhood ALL were 2.91 (95% confidence interval (CI): 1.30-6.51) for maternal pregestational diabetes and 1.75 (95% CI: 1.02-2.98) for maternal gestational diabetes. Paternal diabetes did not alter offspring ALL risk, and we found no association between offspring ALL and later maternal risk of diabetes.CONCLUSIONS: Regardless that absolute ALL risk among offspring of women with diabetes remains low, our findings suggest that characteristics of the diabetic intrauterine environment promote ALL development. This offers a setting for future research into the biological mechanisms underlying childhood ALL.
AB - BACKGROUND: Maternal diabetes may be linked to childhood acute lymphoblastic leukaemia (ALL) in the offspring.METHODS: We assessed the association between maternal pregestational or gestational diabetes and offspring risk of childhood ALL in a register-based study, including all singletons born in Denmark during 1996-2015 (n=1 187 482).RESULTS: Adjusted hazard ratios of childhood ALL were 2.91 (95% confidence interval (CI): 1.30-6.51) for maternal pregestational diabetes and 1.75 (95% CI: 1.02-2.98) for maternal gestational diabetes. Paternal diabetes did not alter offspring ALL risk, and we found no association between offspring ALL and later maternal risk of diabetes.CONCLUSIONS: Regardless that absolute ALL risk among offspring of women with diabetes remains low, our findings suggest that characteristics of the diabetic intrauterine environment promote ALL development. This offers a setting for future research into the biological mechanisms underlying childhood ALL.
U2 - 10.1038/bjc.2017.351
DO - 10.1038/bjc.2017.351
M3 - Journal article
C2 - 28972964
VL - 118
SP - 117
EP - 120
JO - The British journal of cancer. Supplement
JF - The British journal of cancer. Supplement
SN - 0007-0920
IS - 1
ER -
ID: 198662222