Job Strain as a Risk Factor for Peripheral Artery Disease: A Multi-Cohort Study

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

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Job Strain as a Risk Factor for Peripheral Artery Disease : A Multi-Cohort Study. / Heikkilä, Katriina; Pentti, Jaana; Madsen, Ida E.H.; Lallukka, Tea; Virtanen, Marianna; Alfredsson, Lars; Bjørner, Jakob; Borritz, Marianne; Brunner, Eric; Burr, Hermann; Ferrie, Jane E.; Knutsson, Anders; Koskinen, Aki; Leineweber, Constanze; Magnusson Hanson, Linda L.; Nielsen, Martin L.; Nyberg, Solja T.; Oksanen, Tuula; Pejtersen, Jan H.; Pietiläinen, Olli; Rahkonen, Ossi; Rugulies, Reiner; Singh-Manoux, Archana; Steptoe, Andrew; Suominen, Sakari; Theorell, Töres; Vahtera, Jussi; Väänänen, Ari; Westerlund, Hugo; Kivimäki, Mika.

I: Journal of the American Heart Association, Bind 9, Nr. 9, e013538, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Heikkilä, K, Pentti, J, Madsen, IEH, Lallukka, T, Virtanen, M, Alfredsson, L, Bjørner, J, Borritz, M, Brunner, E, Burr, H, Ferrie, JE, Knutsson, A, Koskinen, A, Leineweber, C, Magnusson Hanson, LL, Nielsen, ML, Nyberg, ST, Oksanen, T, Pejtersen, JH, Pietiläinen, O, Rahkonen, O, Rugulies, R, Singh-Manoux, A, Steptoe, A, Suominen, S, Theorell, T, Vahtera, J, Väänänen, A, Westerlund, H & Kivimäki, M 2020, 'Job Strain as a Risk Factor for Peripheral Artery Disease: A Multi-Cohort Study', Journal of the American Heart Association, bind 9, nr. 9, e013538. https://doi.org/10.1161/JAHA.119.013538

APA

Heikkilä, K., Pentti, J., Madsen, I. E. H., Lallukka, T., Virtanen, M., Alfredsson, L., Bjørner, J., Borritz, M., Brunner, E., Burr, H., Ferrie, J. E., Knutsson, A., Koskinen, A., Leineweber, C., Magnusson Hanson, L. L., Nielsen, M. L., Nyberg, S. T., Oksanen, T., Pejtersen, J. H., ... Kivimäki, M. (2020). Job Strain as a Risk Factor for Peripheral Artery Disease: A Multi-Cohort Study. Journal of the American Heart Association, 9(9), [e013538]. https://doi.org/10.1161/JAHA.119.013538

Vancouver

Heikkilä K, Pentti J, Madsen IEH, Lallukka T, Virtanen M, Alfredsson L o.a. Job Strain as a Risk Factor for Peripheral Artery Disease: A Multi-Cohort Study. Journal of the American Heart Association. 2020;9(9). e013538. https://doi.org/10.1161/JAHA.119.013538

Author

Heikkilä, Katriina ; Pentti, Jaana ; Madsen, Ida E.H. ; Lallukka, Tea ; Virtanen, Marianna ; Alfredsson, Lars ; Bjørner, Jakob ; Borritz, Marianne ; Brunner, Eric ; Burr, Hermann ; Ferrie, Jane E. ; Knutsson, Anders ; Koskinen, Aki ; Leineweber, Constanze ; Magnusson Hanson, Linda L. ; Nielsen, Martin L. ; Nyberg, Solja T. ; Oksanen, Tuula ; Pejtersen, Jan H. ; Pietiläinen, Olli ; Rahkonen, Ossi ; Rugulies, Reiner ; Singh-Manoux, Archana ; Steptoe, Andrew ; Suominen, Sakari ; Theorell, Töres ; Vahtera, Jussi ; Väänänen, Ari ; Westerlund, Hugo ; Kivimäki, Mika. / Job Strain as a Risk Factor for Peripheral Artery Disease : A Multi-Cohort Study. I: Journal of the American Heart Association. 2020 ; Bind 9, Nr. 9.

Bibtex

@article{6424467c9ef741878b2643140dfc8782,
title = "Job Strain as a Risk Factor for Peripheral Artery Disease: A Multi-Cohort Study",
abstract = "Background Job strain is implicated in many atherosclerotic diseases, but its role in peripheral artery disease (PAD) is unclear. We investigated the association of job strain with hospital records of PAD, using individual-level data from 11 prospective cohort studies from Finland, Sweden, Denmark, and the United Kingdom. Methods and Results Job strain (high demands and low control at work) was self-reported at baseline (1985-2008). PAD records were ascertained from national hospitalization data. We used Cox regression to examine the associations of job strain with PAD in each study, and combined the study-specific estimates in random effects meta-analyses. We used τ2, I2, and subgroup analyses to examine heterogeneity. Of the 139 132 participants with no previous hospitalization with PAD, 32 489 (23.4%) reported job strain at baseline. During 1 718 132 person-years at risk (mean follow-up 12.8 years), 667 individuals had a hospital record of PAD (3.88 per 10 000 person-years). Job strain was associated with a 1.41-fold (95% CI, 1.11-1.80) increased average risk of hospitalization with PAD. The study-specific estimates were moderately heterogeneous (τ2=0.0427, I2: 26.9%). Despite variation in their magnitude, the estimates were consistent in both sexes, across the socioeconomic hierarchy and by baseline smoking status. Additional adjustment for baseline diabetes mellitus did not change the direction or magnitude of the observed associations. Conclusions Job strain was associated with small but consistent increase in the risk of hospitalization with PAD, with the relative risks on par with those for coronary heart disease and ischemic stroke.",
keywords = "epidemiology, job strain, meta‐analysis, peripheral artery disease, risk factors",
author = "Katriina Heikkil{\"a} and Jaana Pentti and Madsen, {Ida E.H.} and Tea Lallukka and Marianna Virtanen and Lars Alfredsson and Jakob Bj{\o}rner and Marianne Borritz and Eric Brunner and Hermann Burr and Ferrie, {Jane E.} and Anders Knutsson and Aki Koskinen and Constanze Leineweber and {Magnusson Hanson}, {Linda L.} and Nielsen, {Martin L.} and Nyberg, {Solja T.} and Tuula Oksanen and Pejtersen, {Jan H.} and Olli Pietil{\"a}inen and Ossi Rahkonen and Reiner Rugulies and Archana Singh-Manoux and Andrew Steptoe and Sakari Suominen and T{\"o}res Theorell and Jussi Vahtera and Ari V{\"a}{\"a}n{\"a}nen and Hugo Westerlund and Mika Kivim{\"a}ki",
year = "2020",
doi = "10.1161/JAHA.119.013538",
language = "English",
volume = "9",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Job Strain as a Risk Factor for Peripheral Artery Disease

T2 - A Multi-Cohort Study

AU - Heikkilä, Katriina

AU - Pentti, Jaana

AU - Madsen, Ida E.H.

AU - Lallukka, Tea

AU - Virtanen, Marianna

AU - Alfredsson, Lars

AU - Bjørner, Jakob

AU - Borritz, Marianne

AU - Brunner, Eric

AU - Burr, Hermann

AU - Ferrie, Jane E.

AU - Knutsson, Anders

AU - Koskinen, Aki

AU - Leineweber, Constanze

AU - Magnusson Hanson, Linda L.

AU - Nielsen, Martin L.

AU - Nyberg, Solja T.

AU - Oksanen, Tuula

AU - Pejtersen, Jan H.

AU - Pietiläinen, Olli

AU - Rahkonen, Ossi

AU - Rugulies, Reiner

AU - Singh-Manoux, Archana

AU - Steptoe, Andrew

AU - Suominen, Sakari

AU - Theorell, Töres

AU - Vahtera, Jussi

AU - Väänänen, Ari

AU - Westerlund, Hugo

AU - Kivimäki, Mika

PY - 2020

Y1 - 2020

N2 - Background Job strain is implicated in many atherosclerotic diseases, but its role in peripheral artery disease (PAD) is unclear. We investigated the association of job strain with hospital records of PAD, using individual-level data from 11 prospective cohort studies from Finland, Sweden, Denmark, and the United Kingdom. Methods and Results Job strain (high demands and low control at work) was self-reported at baseline (1985-2008). PAD records were ascertained from national hospitalization data. We used Cox regression to examine the associations of job strain with PAD in each study, and combined the study-specific estimates in random effects meta-analyses. We used τ2, I2, and subgroup analyses to examine heterogeneity. Of the 139 132 participants with no previous hospitalization with PAD, 32 489 (23.4%) reported job strain at baseline. During 1 718 132 person-years at risk (mean follow-up 12.8 years), 667 individuals had a hospital record of PAD (3.88 per 10 000 person-years). Job strain was associated with a 1.41-fold (95% CI, 1.11-1.80) increased average risk of hospitalization with PAD. The study-specific estimates were moderately heterogeneous (τ2=0.0427, I2: 26.9%). Despite variation in their magnitude, the estimates were consistent in both sexes, across the socioeconomic hierarchy and by baseline smoking status. Additional adjustment for baseline diabetes mellitus did not change the direction or magnitude of the observed associations. Conclusions Job strain was associated with small but consistent increase in the risk of hospitalization with PAD, with the relative risks on par with those for coronary heart disease and ischemic stroke.

AB - Background Job strain is implicated in many atherosclerotic diseases, but its role in peripheral artery disease (PAD) is unclear. We investigated the association of job strain with hospital records of PAD, using individual-level data from 11 prospective cohort studies from Finland, Sweden, Denmark, and the United Kingdom. Methods and Results Job strain (high demands and low control at work) was self-reported at baseline (1985-2008). PAD records were ascertained from national hospitalization data. We used Cox regression to examine the associations of job strain with PAD in each study, and combined the study-specific estimates in random effects meta-analyses. We used τ2, I2, and subgroup analyses to examine heterogeneity. Of the 139 132 participants with no previous hospitalization with PAD, 32 489 (23.4%) reported job strain at baseline. During 1 718 132 person-years at risk (mean follow-up 12.8 years), 667 individuals had a hospital record of PAD (3.88 per 10 000 person-years). Job strain was associated with a 1.41-fold (95% CI, 1.11-1.80) increased average risk of hospitalization with PAD. The study-specific estimates were moderately heterogeneous (τ2=0.0427, I2: 26.9%). Despite variation in their magnitude, the estimates were consistent in both sexes, across the socioeconomic hierarchy and by baseline smoking status. Additional adjustment for baseline diabetes mellitus did not change the direction or magnitude of the observed associations. Conclusions Job strain was associated with small but consistent increase in the risk of hospitalization with PAD, with the relative risks on par with those for coronary heart disease and ischemic stroke.

KW - epidemiology

KW - job strain

KW - meta‐analysis

KW - peripheral artery disease

KW - risk factors

U2 - 10.1161/JAHA.119.013538

DO - 10.1161/JAHA.119.013538

M3 - Journal article

C2 - 32342765

AN - SCOPUS:85084271212

VL - 9

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 9

M1 - e013538

ER -

ID: 243293474