Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes: a population-based cohort study

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Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes : a population-based cohort study. / Dybdal, Daniel; Tolstrup, Janne S; Sildorf, Stine M; Boisen, Kirsten A; Svensson, Jannet; Skovgaard, Anne Mette; Teilmann, Grete K.

I: Diabetologia, Bind 61, Nr. 4, 01.04.2018, s. 831–838.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Dybdal, D, Tolstrup, JS, Sildorf, SM, Boisen, KA, Svensson, J, Skovgaard, AM & Teilmann, GK 2018, 'Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes: a population-based cohort study', Diabetologia, bind 61, nr. 4, s. 831–838. https://doi.org/10.1007/s00125-017-4517-7

APA

Dybdal, D., Tolstrup, J. S., Sildorf, S. M., Boisen, K. A., Svensson, J., Skovgaard, A. M., & Teilmann, G. K. (2018). Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes: a population-based cohort study. Diabetologia, 61(4), 831–838. https://doi.org/10.1007/s00125-017-4517-7

Vancouver

Dybdal D, Tolstrup JS, Sildorf SM, Boisen KA, Svensson J, Skovgaard AM o.a. Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes: a population-based cohort study. Diabetologia. 2018 apr. 1;61(4):831–838. https://doi.org/10.1007/s00125-017-4517-7

Author

Dybdal, Daniel ; Tolstrup, Janne S ; Sildorf, Stine M ; Boisen, Kirsten A ; Svensson, Jannet ; Skovgaard, Anne Mette ; Teilmann, Grete K. / Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes : a population-based cohort study. I: Diabetologia. 2018 ; Bind 61, Nr. 4. s. 831–838.

Bibtex

@article{9b204674c0ba4696b1b8a68ce948b893,
title = "Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes: a population-based cohort study",
abstract = "AIMS/HYPOTHESIS: The aim of this study was to investigate psychiatric morbidity following childhood onset of type 1 diabetes.METHODS: In a matched, population-based cohort study based on Danish national registers, we identified children and adolescents who had been diagnosed as an in- or outpatient with type 1 diabetes before the age of 18, and afterwards diagnosed with a psychiatric disorder (n = 5084). Control individuals were matched according to sex and date of birth (n = 35,588). The Cox proportional hazards model was used to assess associations between type 1 diabetes and the incidence of psychiatric disorders as well as the effects of age at onset and duration of type 1 diabetes on the risk of subsequently developing psychiatric morbidities.RESULTS: An increased risk of being diagnosed with mood disorders and anxiety, dissociative, eating, stress-related and somatoform disorders was observed in both sexes in the years following type 1 diabetes onset, with the highest risk observed five years or more after onset (HR 1.55 [95% CI 1.38, 1.74]). The risk of psychoactive substance-misuse disorders increased significantly only in boys, and the risk of personality disorders increased only in girls.CONCLUSIONS/INTERPRETATION: In the years following type 1 diabetes onset, an increased risk of eating disorders, anxiety and mood disorders, substance misuse, and personality disorders was found. These findings highlight a clinical need to monitor the mental health of children and adolescents in the years following type 1 diabetes onset to identify and treat psychiatric problems associated with type 1 diabetes.",
author = "Daniel Dybdal and Tolstrup, {Janne S} and Sildorf, {Stine M} and Boisen, {Kirsten A} and Jannet Svensson and Skovgaard, {Anne Mette} and Teilmann, {Grete K}",
year = "2018",
month = apr,
day = "1",
doi = "10.1007/s00125-017-4517-7",
language = "English",
volume = "61",
pages = "831–838",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes

T2 - a population-based cohort study

AU - Dybdal, Daniel

AU - Tolstrup, Janne S

AU - Sildorf, Stine M

AU - Boisen, Kirsten A

AU - Svensson, Jannet

AU - Skovgaard, Anne Mette

AU - Teilmann, Grete K

PY - 2018/4/1

Y1 - 2018/4/1

N2 - AIMS/HYPOTHESIS: The aim of this study was to investigate psychiatric morbidity following childhood onset of type 1 diabetes.METHODS: In a matched, population-based cohort study based on Danish national registers, we identified children and adolescents who had been diagnosed as an in- or outpatient with type 1 diabetes before the age of 18, and afterwards diagnosed with a psychiatric disorder (n = 5084). Control individuals were matched according to sex and date of birth (n = 35,588). The Cox proportional hazards model was used to assess associations between type 1 diabetes and the incidence of psychiatric disorders as well as the effects of age at onset and duration of type 1 diabetes on the risk of subsequently developing psychiatric morbidities.RESULTS: An increased risk of being diagnosed with mood disorders and anxiety, dissociative, eating, stress-related and somatoform disorders was observed in both sexes in the years following type 1 diabetes onset, with the highest risk observed five years or more after onset (HR 1.55 [95% CI 1.38, 1.74]). The risk of psychoactive substance-misuse disorders increased significantly only in boys, and the risk of personality disorders increased only in girls.CONCLUSIONS/INTERPRETATION: In the years following type 1 diabetes onset, an increased risk of eating disorders, anxiety and mood disorders, substance misuse, and personality disorders was found. These findings highlight a clinical need to monitor the mental health of children and adolescents in the years following type 1 diabetes onset to identify and treat psychiatric problems associated with type 1 diabetes.

AB - AIMS/HYPOTHESIS: The aim of this study was to investigate psychiatric morbidity following childhood onset of type 1 diabetes.METHODS: In a matched, population-based cohort study based on Danish national registers, we identified children and adolescents who had been diagnosed as an in- or outpatient with type 1 diabetes before the age of 18, and afterwards diagnosed with a psychiatric disorder (n = 5084). Control individuals were matched according to sex and date of birth (n = 35,588). The Cox proportional hazards model was used to assess associations between type 1 diabetes and the incidence of psychiatric disorders as well as the effects of age at onset and duration of type 1 diabetes on the risk of subsequently developing psychiatric morbidities.RESULTS: An increased risk of being diagnosed with mood disorders and anxiety, dissociative, eating, stress-related and somatoform disorders was observed in both sexes in the years following type 1 diabetes onset, with the highest risk observed five years or more after onset (HR 1.55 [95% CI 1.38, 1.74]). The risk of psychoactive substance-misuse disorders increased significantly only in boys, and the risk of personality disorders increased only in girls.CONCLUSIONS/INTERPRETATION: In the years following type 1 diabetes onset, an increased risk of eating disorders, anxiety and mood disorders, substance misuse, and personality disorders was found. These findings highlight a clinical need to monitor the mental health of children and adolescents in the years following type 1 diabetes onset to identify and treat psychiatric problems associated with type 1 diabetes.

U2 - 10.1007/s00125-017-4517-7

DO - 10.1007/s00125-017-4517-7

M3 - Journal article

C2 - 29242985

VL - 61

SP - 831

EP - 838

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 4

ER -

ID: 190662806