Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes: a population-based cohort study
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Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes : a population-based cohort study. / Dybdal, Daniel; Tolstrup, Janne S; Sildorf, Stine M; Boisen, Kirsten A; Svensson, Jannet; Skovgaard, Anne Mette; Teilmann, Grete K.
I: Diabetologia, Bind 61, Nr. 4, 01.04.2018, s. 831–838.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes
T2 - a population-based cohort study
AU - Dybdal, Daniel
AU - Tolstrup, Janne S
AU - Sildorf, Stine M
AU - Boisen, Kirsten A
AU - Svensson, Jannet
AU - Skovgaard, Anne Mette
AU - Teilmann, Grete K
PY - 2018/4/1
Y1 - 2018/4/1
N2 - AIMS/HYPOTHESIS: The aim of this study was to investigate psychiatric morbidity following childhood onset of type 1 diabetes.METHODS: In a matched, population-based cohort study based on Danish national registers, we identified children and adolescents who had been diagnosed as an in- or outpatient with type 1 diabetes before the age of 18, and afterwards diagnosed with a psychiatric disorder (n = 5084). Control individuals were matched according to sex and date of birth (n = 35,588). The Cox proportional hazards model was used to assess associations between type 1 diabetes and the incidence of psychiatric disorders as well as the effects of age at onset and duration of type 1 diabetes on the risk of subsequently developing psychiatric morbidities.RESULTS: An increased risk of being diagnosed with mood disorders and anxiety, dissociative, eating, stress-related and somatoform disorders was observed in both sexes in the years following type 1 diabetes onset, with the highest risk observed five years or more after onset (HR 1.55 [95% CI 1.38, 1.74]). The risk of psychoactive substance-misuse disorders increased significantly only in boys, and the risk of personality disorders increased only in girls.CONCLUSIONS/INTERPRETATION: In the years following type 1 diabetes onset, an increased risk of eating disorders, anxiety and mood disorders, substance misuse, and personality disorders was found. These findings highlight a clinical need to monitor the mental health of children and adolescents in the years following type 1 diabetes onset to identify and treat psychiatric problems associated with type 1 diabetes.
AB - AIMS/HYPOTHESIS: The aim of this study was to investigate psychiatric morbidity following childhood onset of type 1 diabetes.METHODS: In a matched, population-based cohort study based on Danish national registers, we identified children and adolescents who had been diagnosed as an in- or outpatient with type 1 diabetes before the age of 18, and afterwards diagnosed with a psychiatric disorder (n = 5084). Control individuals were matched according to sex and date of birth (n = 35,588). The Cox proportional hazards model was used to assess associations between type 1 diabetes and the incidence of psychiatric disorders as well as the effects of age at onset and duration of type 1 diabetes on the risk of subsequently developing psychiatric morbidities.RESULTS: An increased risk of being diagnosed with mood disorders and anxiety, dissociative, eating, stress-related and somatoform disorders was observed in both sexes in the years following type 1 diabetes onset, with the highest risk observed five years or more after onset (HR 1.55 [95% CI 1.38, 1.74]). The risk of psychoactive substance-misuse disorders increased significantly only in boys, and the risk of personality disorders increased only in girls.CONCLUSIONS/INTERPRETATION: In the years following type 1 diabetes onset, an increased risk of eating disorders, anxiety and mood disorders, substance misuse, and personality disorders was found. These findings highlight a clinical need to monitor the mental health of children and adolescents in the years following type 1 diabetes onset to identify and treat psychiatric problems associated with type 1 diabetes.
U2 - 10.1007/s00125-017-4517-7
DO - 10.1007/s00125-017-4517-7
M3 - Journal article
C2 - 29242985
VL - 61
SP - 831
EP - 838
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 4
ER -
ID: 190662806