Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man

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Standard

Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man. / Wettergren, A; Petersen, H; Orskov, C; Christiansen, J; Sheikh, S P; Holst, J J.

I: Scandinavian Journal of Gastroenterology, Bind 29, Nr. 6, 06.1994, s. 501-5.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Wettergren, A, Petersen, H, Orskov, C, Christiansen, J, Sheikh, SP & Holst, JJ 1994, 'Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man', Scandinavian Journal of Gastroenterology, bind 29, nr. 6, s. 501-5.

APA

Wettergren, A., Petersen, H., Orskov, C., Christiansen, J., Sheikh, S. P., & Holst, J. J. (1994). Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man. Scandinavian Journal of Gastroenterology, 29(6), 501-5.

Vancouver

Wettergren A, Petersen H, Orskov C, Christiansen J, Sheikh SP, Holst JJ. Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man. Scandinavian Journal of Gastroenterology. 1994 jun.;29(6):501-5.

Author

Wettergren, A ; Petersen, H ; Orskov, C ; Christiansen, J ; Sheikh, S P ; Holst, J J. / Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man. I: Scandinavian Journal of Gastroenterology. 1994 ; Bind 29, Nr. 6. s. 501-5.

Bibtex

@article{f384f25a7cc04b7cb09f5f89d12db094,
title = "Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man",
abstract = "BACKGROUND: Glucagon-like peptide (GLP-1) 7-36 amide and peptide YY (PYY) from the L-cell of the ileal mucosa are potent inhibitors of gastric acid secretion in man. It is not clear, however, by which mechanism(s) they inhibit acid secretion. In dogs the inhibitory effect of PYY on acid secretion may be mediated mainly through neural pathways. The mechanism of action of GLP-1 might be similar. The aim of the present study was to examine the effects of GLP-1 might be similar. The aim of the present study was to examine the effects of GLP-1 and PYY on the vagally induced gastric acid secretion in man.METHODS: A modified sham feeding technique, chew and spit, was used. Six healthy volunteers were randomly assigned to receive intravenous infusion of saline, GLP-1 (41 pmol/kg/h), or peptide YY (50 pmol/kg/h).RESULTS: The infusion of GLP-1 and PYY resulted in plasma concentrations of 60 +/- 9 pmol/l and 84 +/- 11 pmol/l, respectively. GLP-1 and PYY both significantly inhibited the intergrated acid output by 67 +/- 6% and 68 +/- 9%, respectively, compared with the integrated outputs in a control experiment with saline infusion. Serum gastrin and plasma somatostatin concentrations remained unchanged during saline, GLP-1, and PYY infusions.CONCLUSIONS: GLP-1 and PYY are both potent inhibitors of the cephalic phase of acid secretion, indicating that at least part of the inhibitory effect of GLP-1 and PYY in man is mediated through neural pathways. Furthermore, the inhibitory effect seems to be independent of circulating concentrations of gastrin and somatostatin.",
keywords = "Adult, Animals, Depression, Chemical, Female, Gastric Acid/secretion, Gastrins/blood, Glucagon, Glucagon-Like Peptide 1, Glucagon-Like Peptides, Humans, Ileum/chemistry, Intestinal Mucosa/chemistry, L Cells (Cell Line)/chemistry, Male, Mice, Middle Aged, Peptide Fragments/pharmacology, Peptide YY, Peptides/pharmacology, Somatostatin/blood, Vagus Nerve/physiology",
author = "A Wettergren and H Petersen and C Orskov and J Christiansen and Sheikh, {S P} and Holst, {J J}",
year = "1994",
month = jun,
language = "English",
volume = "29",
pages = "501--5",
journal = "Scandinavian Journal of Gastroenterology. Supplement",
issn = "0085-5928",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man

AU - Wettergren, A

AU - Petersen, H

AU - Orskov, C

AU - Christiansen, J

AU - Sheikh, S P

AU - Holst, J J

PY - 1994/6

Y1 - 1994/6

N2 - BACKGROUND: Glucagon-like peptide (GLP-1) 7-36 amide and peptide YY (PYY) from the L-cell of the ileal mucosa are potent inhibitors of gastric acid secretion in man. It is not clear, however, by which mechanism(s) they inhibit acid secretion. In dogs the inhibitory effect of PYY on acid secretion may be mediated mainly through neural pathways. The mechanism of action of GLP-1 might be similar. The aim of the present study was to examine the effects of GLP-1 might be similar. The aim of the present study was to examine the effects of GLP-1 and PYY on the vagally induced gastric acid secretion in man.METHODS: A modified sham feeding technique, chew and spit, was used. Six healthy volunteers were randomly assigned to receive intravenous infusion of saline, GLP-1 (41 pmol/kg/h), or peptide YY (50 pmol/kg/h).RESULTS: The infusion of GLP-1 and PYY resulted in plasma concentrations of 60 +/- 9 pmol/l and 84 +/- 11 pmol/l, respectively. GLP-1 and PYY both significantly inhibited the intergrated acid output by 67 +/- 6% and 68 +/- 9%, respectively, compared with the integrated outputs in a control experiment with saline infusion. Serum gastrin and plasma somatostatin concentrations remained unchanged during saline, GLP-1, and PYY infusions.CONCLUSIONS: GLP-1 and PYY are both potent inhibitors of the cephalic phase of acid secretion, indicating that at least part of the inhibitory effect of GLP-1 and PYY in man is mediated through neural pathways. Furthermore, the inhibitory effect seems to be independent of circulating concentrations of gastrin and somatostatin.

AB - BACKGROUND: Glucagon-like peptide (GLP-1) 7-36 amide and peptide YY (PYY) from the L-cell of the ileal mucosa are potent inhibitors of gastric acid secretion in man. It is not clear, however, by which mechanism(s) they inhibit acid secretion. In dogs the inhibitory effect of PYY on acid secretion may be mediated mainly through neural pathways. The mechanism of action of GLP-1 might be similar. The aim of the present study was to examine the effects of GLP-1 might be similar. The aim of the present study was to examine the effects of GLP-1 and PYY on the vagally induced gastric acid secretion in man.METHODS: A modified sham feeding technique, chew and spit, was used. Six healthy volunteers were randomly assigned to receive intravenous infusion of saline, GLP-1 (41 pmol/kg/h), or peptide YY (50 pmol/kg/h).RESULTS: The infusion of GLP-1 and PYY resulted in plasma concentrations of 60 +/- 9 pmol/l and 84 +/- 11 pmol/l, respectively. GLP-1 and PYY both significantly inhibited the intergrated acid output by 67 +/- 6% and 68 +/- 9%, respectively, compared with the integrated outputs in a control experiment with saline infusion. Serum gastrin and plasma somatostatin concentrations remained unchanged during saline, GLP-1, and PYY infusions.CONCLUSIONS: GLP-1 and PYY are both potent inhibitors of the cephalic phase of acid secretion, indicating that at least part of the inhibitory effect of GLP-1 and PYY in man is mediated through neural pathways. Furthermore, the inhibitory effect seems to be independent of circulating concentrations of gastrin and somatostatin.

KW - Adult

KW - Animals

KW - Depression, Chemical

KW - Female

KW - Gastric Acid/secretion

KW - Gastrins/blood

KW - Glucagon

KW - Glucagon-Like Peptide 1

KW - Glucagon-Like Peptides

KW - Humans

KW - Ileum/chemistry

KW - Intestinal Mucosa/chemistry

KW - L Cells (Cell Line)/chemistry

KW - Male

KW - Mice

KW - Middle Aged

KW - Peptide Fragments/pharmacology

KW - Peptide YY

KW - Peptides/pharmacology

KW - Somatostatin/blood

KW - Vagus Nerve/physiology

M3 - Journal article

C2 - 7915853

VL - 29

SP - 501

EP - 505

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

SN - 0085-5928

IS - 6

ER -

ID: 194816777