Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans

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Standard

Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans. / Christensen, Britt; Dandanell, Sune; Kjaer, Michael; Langberg, Henning.

I: Journal of Applied Physiology, Bind 110, Nr. 1, 2011, s. 137-41.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Christensen, B, Dandanell, S, Kjaer, M & Langberg, H 2011, 'Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans', Journal of Applied Physiology, bind 110, nr. 1, s. 137-41. https://doi.org/10.1152/japplphysiol.00942.2010

APA

Christensen, B., Dandanell, S., Kjaer, M., & Langberg, H. (2011). Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans. Journal of Applied Physiology, 110(1), 137-41. https://doi.org/10.1152/japplphysiol.00942.2010

Vancouver

Christensen B, Dandanell S, Kjaer M, Langberg H. Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans. Journal of Applied Physiology. 2011;110(1):137-41. https://doi.org/10.1152/japplphysiol.00942.2010

Author

Christensen, Britt ; Dandanell, Sune ; Kjaer, Michael ; Langberg, Henning. / Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans. I: Journal of Applied Physiology. 2011 ; Bind 110, Nr. 1. s. 137-41.

Bibtex

@article{790d72a7cfea46ef8d143e804771c995,
title = "Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans",
abstract = "NSAIDs are widely used in the treatment of inflammatory diseases as well as of tendon diseases associated with pain in sports and labor. However, the effect of NSAID intake, and thus blockade of PGE(2) production, on the tendon tissue adaptation is unknown. The purpose of the present study was to elucidate the possible effects of NSAID intake on healthy tendon collagen turnover in relation to a strenuous bout of endurance exercise. Fifteen healthy young men were randomly assigned into two experimental groups, with one group receiving indomethacin (oral 2 × 100 mg Confortid daily for 7 days; NSAID; n = 7) and a placebo group (n = 8). Both groups were exposed to a prolonged bout of running (36 km). The collagen synthesis NH2-terminal propeptide of type I (PINP) and PGE2 concentrations were measured before and 72 h following the run in the patella tendon by microdialysis. The peritendinous concentrations of PINP increased significantly in the placebo group as a result of the run, as shown previously. PGE2 levels were significantly decreased 72 h after the run compared with basal levels in the subjects treated with NSAID and unchanged in the placebo group. The NSAID intake abolished the adaptive increase in collagen synthesis in the patella tendon found in the placebo group in response to the prolonged exercise (P <0.05). The present study demonstrates that intake of NSAID decreased interstitial PGE2 and abolished the exercise-induced adaptive increase in collagen synthesis in human tendons.",
keywords = "Adult, Anti-Inflammatory Agents, Non-Steroidal, Collagen, Dinoprostone, Dose-Response Relationship, Drug, Female, Humans, Indomethacin, Male, Patellar Ligament, Physical Endurance, Running, Up-Regulation",
author = "Britt Christensen and Sune Dandanell and Michael Kjaer and Henning Langberg",
year = "2011",
doi = "10.1152/japplphysiol.00942.2010",
language = "English",
volume = "110",
pages = "137--41",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans

AU - Christensen, Britt

AU - Dandanell, Sune

AU - Kjaer, Michael

AU - Langberg, Henning

PY - 2011

Y1 - 2011

N2 - NSAIDs are widely used in the treatment of inflammatory diseases as well as of tendon diseases associated with pain in sports and labor. However, the effect of NSAID intake, and thus blockade of PGE(2) production, on the tendon tissue adaptation is unknown. The purpose of the present study was to elucidate the possible effects of NSAID intake on healthy tendon collagen turnover in relation to a strenuous bout of endurance exercise. Fifteen healthy young men were randomly assigned into two experimental groups, with one group receiving indomethacin (oral 2 × 100 mg Confortid daily for 7 days; NSAID; n = 7) and a placebo group (n = 8). Both groups were exposed to a prolonged bout of running (36 km). The collagen synthesis NH2-terminal propeptide of type I (PINP) and PGE2 concentrations were measured before and 72 h following the run in the patella tendon by microdialysis. The peritendinous concentrations of PINP increased significantly in the placebo group as a result of the run, as shown previously. PGE2 levels were significantly decreased 72 h after the run compared with basal levels in the subjects treated with NSAID and unchanged in the placebo group. The NSAID intake abolished the adaptive increase in collagen synthesis in the patella tendon found in the placebo group in response to the prolonged exercise (P <0.05). The present study demonstrates that intake of NSAID decreased interstitial PGE2 and abolished the exercise-induced adaptive increase in collagen synthesis in human tendons.

AB - NSAIDs are widely used in the treatment of inflammatory diseases as well as of tendon diseases associated with pain in sports and labor. However, the effect of NSAID intake, and thus blockade of PGE(2) production, on the tendon tissue adaptation is unknown. The purpose of the present study was to elucidate the possible effects of NSAID intake on healthy tendon collagen turnover in relation to a strenuous bout of endurance exercise. Fifteen healthy young men were randomly assigned into two experimental groups, with one group receiving indomethacin (oral 2 × 100 mg Confortid daily for 7 days; NSAID; n = 7) and a placebo group (n = 8). Both groups were exposed to a prolonged bout of running (36 km). The collagen synthesis NH2-terminal propeptide of type I (PINP) and PGE2 concentrations were measured before and 72 h following the run in the patella tendon by microdialysis. The peritendinous concentrations of PINP increased significantly in the placebo group as a result of the run, as shown previously. PGE2 levels were significantly decreased 72 h after the run compared with basal levels in the subjects treated with NSAID and unchanged in the placebo group. The NSAID intake abolished the adaptive increase in collagen synthesis in the patella tendon found in the placebo group in response to the prolonged exercise (P <0.05). The present study demonstrates that intake of NSAID decreased interstitial PGE2 and abolished the exercise-induced adaptive increase in collagen synthesis in human tendons.

KW - Adult

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Collagen

KW - Dinoprostone

KW - Dose-Response Relationship, Drug

KW - Female

KW - Humans

KW - Indomethacin

KW - Male

KW - Patellar Ligament

KW - Physical Endurance

KW - Running

KW - Up-Regulation

U2 - 10.1152/japplphysiol.00942.2010

DO - 10.1152/japplphysiol.00942.2010

M3 - Journal article

C2 - 21030675

VL - 110

SP - 137

EP - 141

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 1

ER -

ID: 38363716