TY - JOUR

T1 - Abdominal fat distribution and cardiovascular risk in men and women with different levels of glucose tolerance.

AU - Scheuer, Stine h.

AU - Faerch, Kirstine

AU - Philipsen, Annelotte

AU - Jørgensen, Marit Eika

AU - Johansen, Nanna B

AU - Carstensen, Bendix

AU - Witte, Daniel R

AU - Andersen, Ingelise

AU - Lauritzen, Torsten

AU - Andersen, Gregers Stig

PY - 2015/9

Y1 - 2015/9

N2 - Context: Regional fat distribution rather than overall obesity has been recognized as important tounderstanding the link between obesity and cardiovascular disease.Objective:We examined the associations of abdominal visceral adipose tissue (VAT) and abdominalsubcutaneous adipose tissue (SAT) with cardiovascular risk factors in a Caucasian population ofmenand women with normal glucose tolerance, prediabetes, or screen-detected diabetes.Design, Setting, and Participants: The study was based on cross-sectional analysis of data from 1412adults age 45– 80 years. VAT and SAT were assessed by ultrasound. The associations of VAT and SATwith blood pressure and lipids were examined by linear regression analysis adjusted for age, sex,smoking, alcohol, physical activity, glucose tolerance status (GTS), medication use, and body massindex. Effect modification by GTS and sex was examined, and stratified analyses performed.Results: Independent of SAT and overall obesity, VAT was associated with higher triglyceride andlower high-density lipoprotein (HDL) cholesterol levels in both men and women and additionallyassociated with higher total cholesterol in men. SAT was independently associated with highertotal cholesterol and low-density lipoprotein cholesterol levels in both sexes, and SAT was additionallyassociated with higher triglyceride and lower HDL cholesterol levels in women andwith higher blood pressure in participants with diabetes.Conclusion: Both abdominal VAT and SAT are independent of overall obesity associated withcardiovascular risk in a population of men and women at low to high risk of diabetes or withscreen-detected diabetes

AB - Context: Regional fat distribution rather than overall obesity has been recognized as important tounderstanding the link between obesity and cardiovascular disease.Objective:We examined the associations of abdominal visceral adipose tissue (VAT) and abdominalsubcutaneous adipose tissue (SAT) with cardiovascular risk factors in a Caucasian population ofmenand women with normal glucose tolerance, prediabetes, or screen-detected diabetes.Design, Setting, and Participants: The study was based on cross-sectional analysis of data from 1412adults age 45– 80 years. VAT and SAT were assessed by ultrasound. The associations of VAT and SATwith blood pressure and lipids were examined by linear regression analysis adjusted for age, sex,smoking, alcohol, physical activity, glucose tolerance status (GTS), medication use, and body massindex. Effect modification by GTS and sex was examined, and stratified analyses performed.Results: Independent of SAT and overall obesity, VAT was associated with higher triglyceride andlower high-density lipoprotein (HDL) cholesterol levels in both men and women and additionallyassociated with higher total cholesterol in men. SAT was independently associated with highertotal cholesterol and low-density lipoprotein cholesterol levels in both sexes, and SAT was additionallyassociated with higher triglyceride and lower HDL cholesterol levels in women andwith higher blood pressure in participants with diabetes.Conclusion: Both abdominal VAT and SAT are independent of overall obesity associated withcardiovascular risk in a population of men and women at low to high risk of diabetes or withscreen-detected diabetes

U2 - 10.1210/JC.2014-4479

DO - 10.1210/JC.2014-4479

M3 - Journal article

C2 - 26120787

VL - 100

SP - 3340

EP - 3347

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 9

ER -