Multimorbidity and mortality: A 15-year longitudinal registry-based nationwide Danish population study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Multimorbidity and mortality : A 15-year longitudinal registry-based nationwide Danish population study. / Willadsen, Tora Grauers; Siersma, Volkert Dirk; Nicolaisdottir, Dagny Ros; Køster-Rasmussen, Rasmus; Jarbøl, Dorte Ejg; Reventlow, Susanne; Mercer, Stewart ; Olivarius, Niels de Fine.

I: Journal of Comorbidity, Bind 8, 8, 2018, s. 1-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Willadsen, TG, Siersma, VD, Nicolaisdottir, DR, Køster-Rasmussen, R, Jarbøl, DE, Reventlow, S, Mercer, S & Olivarius, NDF 2018, 'Multimorbidity and mortality: A 15-year longitudinal registry-based nationwide Danish population study', Journal of Comorbidity, bind 8, 8, s. 1-9. https://doi.org/10.1177/2235042X18804063

APA

Willadsen, T. G., Siersma, V. D., Nicolaisdottir, D. R., Køster-Rasmussen, R., Jarbøl, D. E., Reventlow, S., ... Olivarius, N. D. F. (2018). Multimorbidity and mortality: A 15-year longitudinal registry-based nationwide Danish population study. Journal of Comorbidity, 8, 1-9. [8]. https://doi.org/10.1177/2235042X18804063

Vancouver

Willadsen TG, Siersma VD, Nicolaisdottir DR, Køster-Rasmussen R, Jarbøl DE, Reventlow S o.a. Multimorbidity and mortality: A 15-year longitudinal registry-based nationwide Danish population study. Journal of Comorbidity. 2018;8:1-9. 8. https://doi.org/10.1177/2235042X18804063

Author

Willadsen, Tora Grauers ; Siersma, Volkert Dirk ; Nicolaisdottir, Dagny Ros ; Køster-Rasmussen, Rasmus ; Jarbøl, Dorte Ejg ; Reventlow, Susanne ; Mercer, Stewart ; Olivarius, Niels de Fine. / Multimorbidity and mortality : A 15-year longitudinal registry-based nationwide Danish population study. I: Journal of Comorbidity. 2018 ; Bind 8. s. 1-9.

Bibtex

@article{24e9642cb98c426fa6a2735849410ada,
title = "Multimorbidity and mortality: A 15-year longitudinal registry-based nationwide Danish population study",
abstract = "Background: Knowledge about prevalent and deadly combinations of multimorbidity is needed.Objective: To determine the nationwide prevalence of multimorbidity and estimate mortality for the most prevalent combinations of 1-5 diagnosis groups. Furthermore, to assess the excess mortality of the combination of two groups compared to the product of mortality associated with the single groups. Design: A prospective cohort study using Danish registries and including 3 986 209 people aged ≥18 years on 1 January, 2000. Multimorbidity was defined as having diagnoses from at least two of ten diagnosis groups: lung, musculoskeletal, endocrine, mental, cancer, neurological, gastrointestinal, cardiovascular, kidney, and sensory organs. Logistic regression (odds ratios, OR) and Ratio of ORs (ROR) were used to study mortality and excess mortality.Results: Prevalence of multimorbidity was 7.1{\%} in the Danish population. The most prevalent combination (0.4{\%}) was the musculoskeletal-cardiovascular which had double the mortality (OR 2.03) compared to persons not belonging to any of the diagnosis groups but showed no excess mortality (ROR 0.97). The neurological-cancer combination had the highest mortality (OR 6.35), was less prevalent (0.07{\%}), and had no excess mortality (ROR 0.94). Cardiovascular-lung was moderately prevalent (0.2{\%}), had high mortality (OR 5.75), and had excess mortality (ROR 1.18). Endocrine-kidney had high excess mortality (ROR 1.81) and cancer-mental had low excess mortality (ROR 0.66). Mortality increased with the number of groups.Conclusions: All combinations had increased mortality risk with some of them having up to a six-fold increased risk. Mortality increased with the number of diagnosis groups. Most combinations did not increase mortality above that expected, i.e. were additive rather than synergistic.",
author = "Willadsen, {Tora Grauers} and Siersma, {Volkert Dirk} and Nicolaisdottir, {Dagny Ros} and Rasmus K{\o}ster-Rasmussen and Jarb{\o}l, {Dorte Ejg} and Susanne Reventlow and Stewart Mercer and Olivarius, {Niels de Fine}",
year = "2018",
doi = "10.1177/2235042X18804063",
language = "English",
volume = "8",
pages = "1--9",
journal = "Journal of Comorbidity",
issn = "2235-042X",
publisher = "Swiss Medical Press GmbH",

}

RIS

TY - JOUR

T1 - Multimorbidity and mortality

T2 - A 15-year longitudinal registry-based nationwide Danish population study

AU - Willadsen, Tora Grauers

AU - Siersma, Volkert Dirk

AU - Nicolaisdottir, Dagny Ros

AU - Køster-Rasmussen, Rasmus

AU - Jarbøl, Dorte Ejg

AU - Reventlow, Susanne

AU - Mercer, Stewart

AU - Olivarius, Niels de Fine

PY - 2018

Y1 - 2018

N2 - Background: Knowledge about prevalent and deadly combinations of multimorbidity is needed.Objective: To determine the nationwide prevalence of multimorbidity and estimate mortality for the most prevalent combinations of 1-5 diagnosis groups. Furthermore, to assess the excess mortality of the combination of two groups compared to the product of mortality associated with the single groups. Design: A prospective cohort study using Danish registries and including 3 986 209 people aged ≥18 years on 1 January, 2000. Multimorbidity was defined as having diagnoses from at least two of ten diagnosis groups: lung, musculoskeletal, endocrine, mental, cancer, neurological, gastrointestinal, cardiovascular, kidney, and sensory organs. Logistic regression (odds ratios, OR) and Ratio of ORs (ROR) were used to study mortality and excess mortality.Results: Prevalence of multimorbidity was 7.1% in the Danish population. The most prevalent combination (0.4%) was the musculoskeletal-cardiovascular which had double the mortality (OR 2.03) compared to persons not belonging to any of the diagnosis groups but showed no excess mortality (ROR 0.97). The neurological-cancer combination had the highest mortality (OR 6.35), was less prevalent (0.07%), and had no excess mortality (ROR 0.94). Cardiovascular-lung was moderately prevalent (0.2%), had high mortality (OR 5.75), and had excess mortality (ROR 1.18). Endocrine-kidney had high excess mortality (ROR 1.81) and cancer-mental had low excess mortality (ROR 0.66). Mortality increased with the number of groups.Conclusions: All combinations had increased mortality risk with some of them having up to a six-fold increased risk. Mortality increased with the number of diagnosis groups. Most combinations did not increase mortality above that expected, i.e. were additive rather than synergistic.

AB - Background: Knowledge about prevalent and deadly combinations of multimorbidity is needed.Objective: To determine the nationwide prevalence of multimorbidity and estimate mortality for the most prevalent combinations of 1-5 diagnosis groups. Furthermore, to assess the excess mortality of the combination of two groups compared to the product of mortality associated with the single groups. Design: A prospective cohort study using Danish registries and including 3 986 209 people aged ≥18 years on 1 January, 2000. Multimorbidity was defined as having diagnoses from at least two of ten diagnosis groups: lung, musculoskeletal, endocrine, mental, cancer, neurological, gastrointestinal, cardiovascular, kidney, and sensory organs. Logistic regression (odds ratios, OR) and Ratio of ORs (ROR) were used to study mortality and excess mortality.Results: Prevalence of multimorbidity was 7.1% in the Danish population. The most prevalent combination (0.4%) was the musculoskeletal-cardiovascular which had double the mortality (OR 2.03) compared to persons not belonging to any of the diagnosis groups but showed no excess mortality (ROR 0.97). The neurological-cancer combination had the highest mortality (OR 6.35), was less prevalent (0.07%), and had no excess mortality (ROR 0.94). Cardiovascular-lung was moderately prevalent (0.2%), had high mortality (OR 5.75), and had excess mortality (ROR 1.18). Endocrine-kidney had high excess mortality (ROR 1.81) and cancer-mental had low excess mortality (ROR 0.66). Mortality increased with the number of groups.Conclusions: All combinations had increased mortality risk with some of them having up to a six-fold increased risk. Mortality increased with the number of diagnosis groups. Most combinations did not increase mortality above that expected, i.e. were additive rather than synergistic.

U2 - 10.1177/2235042X18804063

DO - 10.1177/2235042X18804063

M3 - Journal article

VL - 8

SP - 1

EP - 9

JO - Journal of Comorbidity

JF - Journal of Comorbidity

SN - 2235-042X

M1 - 8

ER -

ID: 218655977