Exploring the feasibility and synergistic value of the One Health approach in clinical research: protocol for a prospective observational study of diagnostic pathways in human and canine patients with suspected urinary tract infection

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Exploring the feasibility and synergistic value of the One Health approach in clinical research : protocol for a prospective observational study of diagnostic pathways in human and canine patients with suspected urinary tract infection. / Cordoba Currea, Gloria Cristina; Sørensen, Tina Møller; Holm, Anne; Bjørnvad, Charlotte Reinhard; Bjerrum, Lars; Jessen, Lisbeth Rem.

I: Pilot and Feasibility Studies, Bind 1, 38, 10.11.2015.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Cordoba Currea, GC, Sørensen, TM, Holm, A, Bjørnvad, CR, Bjerrum, L & Jessen, LR 2015, 'Exploring the feasibility and synergistic value of the One Health approach in clinical research: protocol for a prospective observational study of diagnostic pathways in human and canine patients with suspected urinary tract infection', Pilot and Feasibility Studies, bind 1, 38. https://doi.org/10.1186/s40814-015-0036-9

APA

Cordoba Currea, G. C., Sørensen, T. M., Holm, A., Bjørnvad, C. R., Bjerrum, L., & Jessen, L. R. (2015). Exploring the feasibility and synergistic value of the One Health approach in clinical research: protocol for a prospective observational study of diagnostic pathways in human and canine patients with suspected urinary tract infection. Pilot and Feasibility Studies, 1, [38]. https://doi.org/10.1186/s40814-015-0036-9

Vancouver

Cordoba Currea GC, Sørensen TM, Holm A, Bjørnvad CR, Bjerrum L, Jessen LR. Exploring the feasibility and synergistic value of the One Health approach in clinical research: protocol for a prospective observational study of diagnostic pathways in human and canine patients with suspected urinary tract infection. Pilot and Feasibility Studies. 2015 nov 10;1. 38. https://doi.org/10.1186/s40814-015-0036-9

Author

Cordoba Currea, Gloria Cristina ; Sørensen, Tina Møller ; Holm, Anne ; Bjørnvad, Charlotte Reinhard ; Bjerrum, Lars ; Jessen, Lisbeth Rem. / Exploring the feasibility and synergistic value of the One Health approach in clinical research : protocol for a prospective observational study of diagnostic pathways in human and canine patients with suspected urinary tract infection. I: Pilot and Feasibility Studies. 2015 ; Bind 1.

Bibtex

@article{59abf05ee1bb4b808140280f9f13b9f1,
title = "Exploring the feasibility and synergistic value of the One Health approach in clinical research: protocol for a prospective observational study of diagnostic pathways in human and canine patients with suspected urinary tract infection",
abstract = "Background: The One Health approach is emerging in response to the development of bacterial resistance. To thebest of our knowledge, the possibility to use this approach in a clinical context has not yet been explored. Thus, inthis paper, we report the procedures to implement a prospective observational study of diagnostic pathways in humanand canine patients with suspected urinary tract infection as a means to assess the feasibility and synergistic value ofsetting up One Health clinical research projects and interventions.Methods/design: A prospective observational study will compare different diagnostic pathways (i.e., 16 possiblecombinations of diagnostic tools) to gold standard in human and veterinary primary care practice in Denmark.Fifty primary care practices and 100 veterinary clinics will each consecutively include 20 human patients or 8–10dogs, respectively. Data will be collected at practice and patient level comprising (a) information about the organizationof the practice and access to different diagnostic tools, (b) information about clinical history, diagnostic path andtreatment during the index consultation, (c) information about severity of symptoms during the 7–10 days followinginclusion, and (d) urine culture (type of microorganism and susceptibility test). The feasibility and synergistic value ofconducting future research, and/or designing common interventions, will be assessed by evaluating the comparabilityof human primary care and veterinary primary care with respect to study implementation and study results.Discussion: Results from this study will give an insight into the feasibility and synergistic value of setting-up One Healthresearch projects in a clinical context. This is crucial if we are to embrace the One Health approach, as a legitimatestrategy to implement common interventions aimed at influencing the diagnostic process in human and caninepatients in order to decrease inappropriate use of antibiotics.Trial registration: The study in humans has been registered in ClinicalTrials.gov NCT02249273.",
author = "{Cordoba Currea}, {Gloria Cristina} and S{\o}rensen, {Tina M{\o}ller} and Anne Holm and Bj{\o}rnvad, {Charlotte Reinhard} and Lars Bjerrum and Jessen, {Lisbeth Rem}",
year = "2015",
month = "11",
day = "10",
doi = "10.1186/s40814-015-0036-9",
language = "English",
volume = "1",
journal = "Pilot and Feasibility Studies",
issn = "2055-5784",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Exploring the feasibility and synergistic value of the One Health approach in clinical research

T2 - protocol for a prospective observational study of diagnostic pathways in human and canine patients with suspected urinary tract infection

AU - Cordoba Currea, Gloria Cristina

AU - Sørensen, Tina Møller

AU - Holm, Anne

AU - Bjørnvad, Charlotte Reinhard

AU - Bjerrum, Lars

AU - Jessen, Lisbeth Rem

PY - 2015/11/10

Y1 - 2015/11/10

N2 - Background: The One Health approach is emerging in response to the development of bacterial resistance. To thebest of our knowledge, the possibility to use this approach in a clinical context has not yet been explored. Thus, inthis paper, we report the procedures to implement a prospective observational study of diagnostic pathways in humanand canine patients with suspected urinary tract infection as a means to assess the feasibility and synergistic value ofsetting up One Health clinical research projects and interventions.Methods/design: A prospective observational study will compare different diagnostic pathways (i.e., 16 possiblecombinations of diagnostic tools) to gold standard in human and veterinary primary care practice in Denmark.Fifty primary care practices and 100 veterinary clinics will each consecutively include 20 human patients or 8–10dogs, respectively. Data will be collected at practice and patient level comprising (a) information about the organizationof the practice and access to different diagnostic tools, (b) information about clinical history, diagnostic path andtreatment during the index consultation, (c) information about severity of symptoms during the 7–10 days followinginclusion, and (d) urine culture (type of microorganism and susceptibility test). The feasibility and synergistic value ofconducting future research, and/or designing common interventions, will be assessed by evaluating the comparabilityof human primary care and veterinary primary care with respect to study implementation and study results.Discussion: Results from this study will give an insight into the feasibility and synergistic value of setting-up One Healthresearch projects in a clinical context. This is crucial if we are to embrace the One Health approach, as a legitimatestrategy to implement common interventions aimed at influencing the diagnostic process in human and caninepatients in order to decrease inappropriate use of antibiotics.Trial registration: The study in humans has been registered in ClinicalTrials.gov NCT02249273.

AB - Background: The One Health approach is emerging in response to the development of bacterial resistance. To thebest of our knowledge, the possibility to use this approach in a clinical context has not yet been explored. Thus, inthis paper, we report the procedures to implement a prospective observational study of diagnostic pathways in humanand canine patients with suspected urinary tract infection as a means to assess the feasibility and synergistic value ofsetting up One Health clinical research projects and interventions.Methods/design: A prospective observational study will compare different diagnostic pathways (i.e., 16 possiblecombinations of diagnostic tools) to gold standard in human and veterinary primary care practice in Denmark.Fifty primary care practices and 100 veterinary clinics will each consecutively include 20 human patients or 8–10dogs, respectively. Data will be collected at practice and patient level comprising (a) information about the organizationof the practice and access to different diagnostic tools, (b) information about clinical history, diagnostic path andtreatment during the index consultation, (c) information about severity of symptoms during the 7–10 days followinginclusion, and (d) urine culture (type of microorganism and susceptibility test). The feasibility and synergistic value ofconducting future research, and/or designing common interventions, will be assessed by evaluating the comparabilityof human primary care and veterinary primary care with respect to study implementation and study results.Discussion: Results from this study will give an insight into the feasibility and synergistic value of setting-up One Healthresearch projects in a clinical context. This is crucial if we are to embrace the One Health approach, as a legitimatestrategy to implement common interventions aimed at influencing the diagnostic process in human and caninepatients in order to decrease inappropriate use of antibiotics.Trial registration: The study in humans has been registered in ClinicalTrials.gov NCT02249273.

U2 - 10.1186/s40814-015-0036-9

DO - 10.1186/s40814-015-0036-9

M3 - Journal article

VL - 1

JO - Pilot and Feasibility Studies

JF - Pilot and Feasibility Studies

SN - 2055-5784

M1 - 38

ER -

ID: 150984095