Specific location of ocular adnexal lymphoma and mortality: an international multicentre retrospective study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Specific location of ocular adnexal lymphoma and mortality : an international multicentre retrospective study. / Vest, Stine Dahl; Coupland, Sarah E; Esmaeli, Bita; Finger, Paul T; Graue, Gerardo F; Grossniklaus, Hans E; Hindso, Tine Gadegaard; Holm, Frederik; Honavar, Santosh G; Khong, Jwu Jin; Kirkegaard, Marina Knudsen; McKelvie, Penelope A; Mikkelsen, Lauge Hjorth; Mulay, Kaustubh; Rasmussen, Peter Kristian; Siersma, Volkert; Sjö, Lene Dissing; Sniegowski, Matthew C; Thuro, Bradley A; Vemuganti, Geeta K; Heegaard, Steffen.
I: British Journal of Ophthalmology, Bind 107, Nr. 9, 2023, s. 1231-1238.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Specific location of ocular adnexal lymphoma and mortality
T2 - an international multicentre retrospective study
AU - Vest, Stine Dahl
AU - Coupland, Sarah E
AU - Esmaeli, Bita
AU - Finger, Paul T
AU - Graue, Gerardo F
AU - Grossniklaus, Hans E
AU - Hindso, Tine Gadegaard
AU - Holm, Frederik
AU - Honavar, Santosh G
AU - Khong, Jwu Jin
AU - Kirkegaard, Marina Knudsen
AU - McKelvie, Penelope A
AU - Mikkelsen, Lauge Hjorth
AU - Mulay, Kaustubh
AU - Rasmussen, Peter Kristian
AU - Siersma, Volkert
AU - Sjö, Lene Dissing
AU - Sniegowski, Matthew C
AU - Thuro, Bradley A
AU - Vemuganti, Geeta K
AU - Heegaard, Steffen
N1 - © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2023
Y1 - 2023
N2 - AIMS: To examine whether the specific location of ocular adnexal lymphoma (OAL) and the American Joint Committee on Cancer (AJCC) TNM tumour stage are prognostic factors for mortality in the main OAL subtypes.METHODS: Clinical and survival data were retrospectively collected from seven international eye cancer centres. All patients from 1980 to 2017 with histologically verified primary or secondary OAL were included. Cox regression was used to compare the ocular adnexal tumour locations on all-cause mortality and disease-specific mortality.RESULTS: OAL was identified in 1168 patients. The most frequent lymphoma subtypes were extranodal marginal zone B-cell lymphoma (EMZL) (n=688, 59%); follicular lymphoma (FL) (n=150, 13%); diffuse large B-cell lymphoma (DLBCL) (n=131, 11%); and mantle cell lymphoma (MCL) (n=89, 8%). AJCC/TNM tumour-stage (T-stage) was significantly associated with disease-specific mortality in primary ocular adnexal EMZL and increased through T-categories from T1 to T3 disease. No associations between AJCC/TNM T-stage and mortality were found in primary ocular adnexal FL, DLBCL, or MCL. EMZL located in the eyelid had a significantly increased disease-specific mortality compared with orbital and conjunctival EMZL, in both primary EMZL and the full EMZL cohort. In DLBCL, eyelid location had a significantly higher disease-specific mortality compared with an orbital or lacrimal gland location.CONCLUSION: Disease-specific mortality is associated with AJCC/TNM T-stage in primary ocular adnexal EMZL patients. Lymphoma of the eyelid has the highest disease-specific mortality in primary EMZL, and in the full cohort of EMZL and DLBCL patients.
AB - AIMS: To examine whether the specific location of ocular adnexal lymphoma (OAL) and the American Joint Committee on Cancer (AJCC) TNM tumour stage are prognostic factors for mortality in the main OAL subtypes.METHODS: Clinical and survival data were retrospectively collected from seven international eye cancer centres. All patients from 1980 to 2017 with histologically verified primary or secondary OAL were included. Cox regression was used to compare the ocular adnexal tumour locations on all-cause mortality and disease-specific mortality.RESULTS: OAL was identified in 1168 patients. The most frequent lymphoma subtypes were extranodal marginal zone B-cell lymphoma (EMZL) (n=688, 59%); follicular lymphoma (FL) (n=150, 13%); diffuse large B-cell lymphoma (DLBCL) (n=131, 11%); and mantle cell lymphoma (MCL) (n=89, 8%). AJCC/TNM tumour-stage (T-stage) was significantly associated with disease-specific mortality in primary ocular adnexal EMZL and increased through T-categories from T1 to T3 disease. No associations between AJCC/TNM T-stage and mortality were found in primary ocular adnexal FL, DLBCL, or MCL. EMZL located in the eyelid had a significantly increased disease-specific mortality compared with orbital and conjunctival EMZL, in both primary EMZL and the full EMZL cohort. In DLBCL, eyelid location had a significantly higher disease-specific mortality compared with an orbital or lacrimal gland location.CONCLUSION: Disease-specific mortality is associated with AJCC/TNM T-stage in primary ocular adnexal EMZL patients. Lymphoma of the eyelid has the highest disease-specific mortality in primary EMZL, and in the full cohort of EMZL and DLBCL patients.
U2 - 10.1136/bjophthalmol-2021-320466
DO - 10.1136/bjophthalmol-2021-320466
M3 - Journal article
C2 - 35512851
VL - 107
SP - 1231
EP - 1238
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 9
ER -
ID: 306197128