Is the effect of alcohol on risk of stroke confined to highly stressed persons?

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Is the effect of alcohol on risk of stroke confined to highly stressed persons? / Nielsen, N R; Truelsen, T; Barefoot, J C; Johnsen, S P; Overvad, K; Boysen, G; Schnohr, P; Grønbaek, M.

In: Neuroepidemiology, Vol. 25, No. 3, 2005, p. 105-13.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Nielsen, NR, Truelsen, T, Barefoot, JC, Johnsen, SP, Overvad, K, Boysen, G, Schnohr, P & Grønbaek, M 2005, 'Is the effect of alcohol on risk of stroke confined to highly stressed persons?', Neuroepidemiology, vol. 25, no. 3, pp. 105-13. https://doi.org/10.1159/000086352

APA

Nielsen, N. R., Truelsen, T., Barefoot, J. C., Johnsen, S. P., Overvad, K., Boysen, G., ... Grønbaek, M. (2005). Is the effect of alcohol on risk of stroke confined to highly stressed persons? Neuroepidemiology, 25(3), 105-13. https://doi.org/10.1159/000086352

Vancouver

Nielsen NR, Truelsen T, Barefoot JC, Johnsen SP, Overvad K, Boysen G et al. Is the effect of alcohol on risk of stroke confined to highly stressed persons? Neuroepidemiology. 2005;25(3):105-13. https://doi.org/10.1159/000086352

Author

Nielsen, N R ; Truelsen, T ; Barefoot, J C ; Johnsen, S P ; Overvad, K ; Boysen, G ; Schnohr, P ; Grønbaek, M. / Is the effect of alcohol on risk of stroke confined to highly stressed persons?. In: Neuroepidemiology. 2005 ; Vol. 25, No. 3. pp. 105-13.

Bibtex

@article{d71a7380de3911ddb5fc000ea68e967b,
title = "Is the effect of alcohol on risk of stroke confined to highly stressed persons?",
abstract = "BACKGROUND: Psychological stress and alcohol are both suggested as risk factors for stroke. Further, there appears to be a close relation between stress and alcohol consumption. Several experimental studies have found alcohol consumption to reduce the immediate effects of stress in a laboratory setting. We aimed to examine whether the association between alcohol and stroke depends on level of self-reported stress in a large prospective cohort. METHODS: The 5,373 men and 6,723 women participating in the second examination of the Copenhagen City Heart Study in 1981-1983 were asked at baseline about their self-reported level of stress and their weekly alcohol consumption. The participants were followed-up until 31st of December 1997 during which 880 first ever stroke events occurred. Data were analysed by means of Cox regression modelling. RESULTS: At a high stress level, weekly total consumption of 1-14 units of alcohol compared with no consumption seemed associated with a lower risk of stroke (adjusted RR: 0.57, 95{\%} CI: 0.31-1.07). At lower stress levels, no clear associations were observed. Regarding subtypes, self-reported stress appeared only to modify the association between alcohol intake and ischaemic stroke events. Regarding specific types of alcoholic beverages, self-reported stress only modified the associations for intake of beer and wine. CONCLUSIONS: This study indicates that the apparent lower risk of stroke associated with moderate alcohol consumption is confined to a group of highly stressed persons. It is suggested that alcohol consumption may play a role in reducing the risk of stroke by modifying the physiological or psychological stress response.",
author = "Nielsen, {N R} and T Truelsen and Barefoot, {J C} and Johnsen, {S P} and K Overvad and G Boysen and P Schnohr and M Gr{\o}nbaek",
note = "Keywords: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Alcoholic Beverages; Denmark; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Self Assessment (Psychology); Stress, Psychological; Stroke",
year = "2005",
doi = "10.1159/000086352",
language = "English",
volume = "25",
pages = "105--13",
journal = "Neuroepidemiology",
issn = "0251-5350",
publisher = "S Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - Is the effect of alcohol on risk of stroke confined to highly stressed persons?

AU - Nielsen, N R

AU - Truelsen, T

AU - Barefoot, J C

AU - Johnsen, S P

AU - Overvad, K

AU - Boysen, G

AU - Schnohr, P

AU - Grønbaek, M

N1 - Keywords: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Alcoholic Beverages; Denmark; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Self Assessment (Psychology); Stress, Psychological; Stroke

PY - 2005

Y1 - 2005

N2 - BACKGROUND: Psychological stress and alcohol are both suggested as risk factors for stroke. Further, there appears to be a close relation between stress and alcohol consumption. Several experimental studies have found alcohol consumption to reduce the immediate effects of stress in a laboratory setting. We aimed to examine whether the association between alcohol and stroke depends on level of self-reported stress in a large prospective cohort. METHODS: The 5,373 men and 6,723 women participating in the second examination of the Copenhagen City Heart Study in 1981-1983 were asked at baseline about their self-reported level of stress and their weekly alcohol consumption. The participants were followed-up until 31st of December 1997 during which 880 first ever stroke events occurred. Data were analysed by means of Cox regression modelling. RESULTS: At a high stress level, weekly total consumption of 1-14 units of alcohol compared with no consumption seemed associated with a lower risk of stroke (adjusted RR: 0.57, 95% CI: 0.31-1.07). At lower stress levels, no clear associations were observed. Regarding subtypes, self-reported stress appeared only to modify the association between alcohol intake and ischaemic stroke events. Regarding specific types of alcoholic beverages, self-reported stress only modified the associations for intake of beer and wine. CONCLUSIONS: This study indicates that the apparent lower risk of stroke associated with moderate alcohol consumption is confined to a group of highly stressed persons. It is suggested that alcohol consumption may play a role in reducing the risk of stroke by modifying the physiological or psychological stress response.

AB - BACKGROUND: Psychological stress and alcohol are both suggested as risk factors for stroke. Further, there appears to be a close relation between stress and alcohol consumption. Several experimental studies have found alcohol consumption to reduce the immediate effects of stress in a laboratory setting. We aimed to examine whether the association between alcohol and stroke depends on level of self-reported stress in a large prospective cohort. METHODS: The 5,373 men and 6,723 women participating in the second examination of the Copenhagen City Heart Study in 1981-1983 were asked at baseline about their self-reported level of stress and their weekly alcohol consumption. The participants were followed-up until 31st of December 1997 during which 880 first ever stroke events occurred. Data were analysed by means of Cox regression modelling. RESULTS: At a high stress level, weekly total consumption of 1-14 units of alcohol compared with no consumption seemed associated with a lower risk of stroke (adjusted RR: 0.57, 95% CI: 0.31-1.07). At lower stress levels, no clear associations were observed. Regarding subtypes, self-reported stress appeared only to modify the association between alcohol intake and ischaemic stroke events. Regarding specific types of alcoholic beverages, self-reported stress only modified the associations for intake of beer and wine. CONCLUSIONS: This study indicates that the apparent lower risk of stroke associated with moderate alcohol consumption is confined to a group of highly stressed persons. It is suggested that alcohol consumption may play a role in reducing the risk of stroke by modifying the physiological or psychological stress response.

U2 - 10.1159/000086352

DO - 10.1159/000086352

M3 - Journal article

C2 - 15956807

VL - 25

SP - 105

EP - 113

JO - Neuroepidemiology

JF - Neuroepidemiology

SN - 0251-5350

IS - 3

ER -

ID: 9612785