Is the effect of alcohol on risk of stroke confined to highly stressed persons?

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Standard

Is the effect of alcohol on risk of stroke confined to highly stressed persons? / Nielsen, N R; Truelsen, T; Barefoot, J C; Johnsen, S P; Overvad, K; Boysen, G; Schnohr, P; Grønbaek, M.

In: Neuroepidemiology, Vol. 25, No. 3, 2005, p. 105-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, NR, Truelsen, T, Barefoot, JC, Johnsen, SP, Overvad, K, Boysen, G, Schnohr, P & Grønbaek, M 2005, 'Is the effect of alcohol on risk of stroke confined to highly stressed persons?', Neuroepidemiology, vol. 25, no. 3, pp. 105-13. https://doi.org/10.1159/000086352

APA

Nielsen, N. R., Truelsen, T., Barefoot, J. C., Johnsen, S. P., Overvad, K., Boysen, G., Schnohr, P., & Grønbaek, M. (2005). Is the effect of alcohol on risk of stroke confined to highly stressed persons? Neuroepidemiology, 25(3), 105-13. https://doi.org/10.1159/000086352

Vancouver

Nielsen NR, Truelsen T, Barefoot JC, Johnsen SP, Overvad K, Boysen G et al. Is the effect of alcohol on risk of stroke confined to highly stressed persons? Neuroepidemiology. 2005;25(3):105-13. https://doi.org/10.1159/000086352

Author

Nielsen, N R ; Truelsen, T ; Barefoot, J C ; Johnsen, S P ; Overvad, K ; Boysen, G ; Schnohr, P ; Grønbaek, M. / Is the effect of alcohol on risk of stroke confined to highly stressed persons?. In: Neuroepidemiology. 2005 ; Vol. 25, No. 3. pp. 105-13.

Bibtex

@article{d71a7380de3911ddb5fc000ea68e967b,
title = "Is the effect of alcohol on risk of stroke confined to highly stressed persons?",
abstract = "BACKGROUND: Psychological stress and alcohol are both suggested as risk factors for stroke. Further, there appears to be a close relation between stress and alcohol consumption. Several experimental studies have found alcohol consumption to reduce the immediate effects of stress in a laboratory setting. We aimed to examine whether the association between alcohol and stroke depends on level of self-reported stress in a large prospective cohort. METHODS: The 5,373 men and 6,723 women participating in the second examination of the Copenhagen City Heart Study in 1981-1983 were asked at baseline about their self-reported level of stress and their weekly alcohol consumption. The participants were followed-up until 31st of December 1997 during which 880 first ever stroke events occurred. Data were analysed by means of Cox regression modelling. RESULTS: At a high stress level, weekly total consumption of 1-14 units of alcohol compared with no consumption seemed associated with a lower risk of stroke (adjusted RR: 0.57, 95% CI: 0.31-1.07). At lower stress levels, no clear associations were observed. Regarding subtypes, self-reported stress appeared only to modify the association between alcohol intake and ischaemic stroke events. Regarding specific types of alcoholic beverages, self-reported stress only modified the associations for intake of beer and wine. CONCLUSIONS: This study indicates that the apparent lower risk of stroke associated with moderate alcohol consumption is confined to a group of highly stressed persons. It is suggested that alcohol consumption may play a role in reducing the risk of stroke by modifying the physiological or psychological stress response.",
author = "Nielsen, {N R} and T Truelsen and Barefoot, {J C} and Johnsen, {S P} and K Overvad and G Boysen and P Schnohr and M Gr{\o}nbaek",
note = "Keywords: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Alcoholic Beverages; Denmark; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Self Assessment (Psychology); Stress, Psychological; Stroke",
year = "2005",
doi = "10.1159/000086352",
language = "English",
volume = "25",
pages = "105--13",
journal = "Neuroepidemiology",
issn = "0251-5350",
publisher = "S Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - Is the effect of alcohol on risk of stroke confined to highly stressed persons?

AU - Nielsen, N R

AU - Truelsen, T

AU - Barefoot, J C

AU - Johnsen, S P

AU - Overvad, K

AU - Boysen, G

AU - Schnohr, P

AU - Grønbaek, M

N1 - Keywords: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Alcoholic Beverages; Denmark; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Self Assessment (Psychology); Stress, Psychological; Stroke

PY - 2005

Y1 - 2005

N2 - BACKGROUND: Psychological stress and alcohol are both suggested as risk factors for stroke. Further, there appears to be a close relation between stress and alcohol consumption. Several experimental studies have found alcohol consumption to reduce the immediate effects of stress in a laboratory setting. We aimed to examine whether the association between alcohol and stroke depends on level of self-reported stress in a large prospective cohort. METHODS: The 5,373 men and 6,723 women participating in the second examination of the Copenhagen City Heart Study in 1981-1983 were asked at baseline about their self-reported level of stress and their weekly alcohol consumption. The participants were followed-up until 31st of December 1997 during which 880 first ever stroke events occurred. Data were analysed by means of Cox regression modelling. RESULTS: At a high stress level, weekly total consumption of 1-14 units of alcohol compared with no consumption seemed associated with a lower risk of stroke (adjusted RR: 0.57, 95% CI: 0.31-1.07). At lower stress levels, no clear associations were observed. Regarding subtypes, self-reported stress appeared only to modify the association between alcohol intake and ischaemic stroke events. Regarding specific types of alcoholic beverages, self-reported stress only modified the associations for intake of beer and wine. CONCLUSIONS: This study indicates that the apparent lower risk of stroke associated with moderate alcohol consumption is confined to a group of highly stressed persons. It is suggested that alcohol consumption may play a role in reducing the risk of stroke by modifying the physiological or psychological stress response.

AB - BACKGROUND: Psychological stress and alcohol are both suggested as risk factors for stroke. Further, there appears to be a close relation between stress and alcohol consumption. Several experimental studies have found alcohol consumption to reduce the immediate effects of stress in a laboratory setting. We aimed to examine whether the association between alcohol and stroke depends on level of self-reported stress in a large prospective cohort. METHODS: The 5,373 men and 6,723 women participating in the second examination of the Copenhagen City Heart Study in 1981-1983 were asked at baseline about their self-reported level of stress and their weekly alcohol consumption. The participants were followed-up until 31st of December 1997 during which 880 first ever stroke events occurred. Data were analysed by means of Cox regression modelling. RESULTS: At a high stress level, weekly total consumption of 1-14 units of alcohol compared with no consumption seemed associated with a lower risk of stroke (adjusted RR: 0.57, 95% CI: 0.31-1.07). At lower stress levels, no clear associations were observed. Regarding subtypes, self-reported stress appeared only to modify the association between alcohol intake and ischaemic stroke events. Regarding specific types of alcoholic beverages, self-reported stress only modified the associations for intake of beer and wine. CONCLUSIONS: This study indicates that the apparent lower risk of stroke associated with moderate alcohol consumption is confined to a group of highly stressed persons. It is suggested that alcohol consumption may play a role in reducing the risk of stroke by modifying the physiological or psychological stress response.

U2 - 10.1159/000086352

DO - 10.1159/000086352

M3 - Journal article

C2 - 15956807

VL - 25

SP - 105

EP - 113

JO - Neuroepidemiology

JF - Neuroepidemiology

SN - 0251-5350

IS - 3

ER -

ID: 9612785