Urinary phthalate metabolites concentrations and symptoms of depression in an elderly population

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Urinary phthalate metabolites concentrations and symptoms of depression in an elderly population. / Lee, Kyung-Shin; Lim, Youn-Hee; Kim, Kyoung-Nam; Choi, Yoon-Hyeong; Hong, Yun-Chul; Lee, Nami.

I: The Science of the Total Environment, Bind 625, 2018, s. 1191-1197.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lee, K-S, Lim, Y-H, Kim, K-N, Choi, Y-H, Hong, Y-C & Lee, N 2018, 'Urinary phthalate metabolites concentrations and symptoms of depression in an elderly population', The Science of the Total Environment, bind 625, s. 1191-1197. https://doi.org/10.1016/j.scitotenv.2017.12.219

APA

Lee, K-S., Lim, Y-H., Kim, K-N., Choi, Y-H., Hong, Y-C., & Lee, N. (2018). Urinary phthalate metabolites concentrations and symptoms of depression in an elderly population. The Science of the Total Environment, 625, 1191-1197. https://doi.org/10.1016/j.scitotenv.2017.12.219

Vancouver

Lee K-S, Lim Y-H, Kim K-N, Choi Y-H, Hong Y-C, Lee N. Urinary phthalate metabolites concentrations and symptoms of depression in an elderly population. The Science of the Total Environment. 2018;625:1191-1197. https://doi.org/10.1016/j.scitotenv.2017.12.219

Author

Lee, Kyung-Shin ; Lim, Youn-Hee ; Kim, Kyoung-Nam ; Choi, Yoon-Hyeong ; Hong, Yun-Chul ; Lee, Nami. / Urinary phthalate metabolites concentrations and symptoms of depression in an elderly population. I: The Science of the Total Environment. 2018 ; Bind 625. s. 1191-1197.

Bibtex

@article{8668f2ae7b8249cea3389fc340cbc8b6,

title = "Urinary phthalate metabolites concentrations and symptoms of depression in an elderly population",

abstract = "BACKGROUND: Animal studies have reported an association between phthalates and depression, although there is limited evidence from epidemiological studies. We investigated the association between phthalate exposure and symptoms of depression in an elderly population.METHODS: Repeated measures surveys up to three times were conducted during the study period (2012-2014) in the 535 elderly subjects. We measured the following urinary phthalate metabolite levels: mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-n-butyl phthalate (MnBP), and mono-benzyl phthalate (MBzP). MEHHP, MEOHP, and MECPP are metabolites of diethylhexyl phthalates (DEHP). MnBP and MBzP are metabolites of dibutyl phthalate and butyl benzyl phthalate, respectively. The phthalate metabolite concentrations were evaluated to identify associations with the symptoms of depression using the Korean version of the Geriatric Depression Scale-Short Form (SGDS-K). After factor analysis of the components of SGDS-K, we evaluated the association between phthalate exposure and SGDS-K subgroups to determine which symptoms of depression were affected by phthalate exposure.RESULTS: Concentrations of DEHP metabolites were positively associated with the risk of depressive symptoms in the elderly population (Odds ratio (95% confidence interval); 1.92 (1.17-3.13) for sum of three DEHP metabolites), while we found no significant association between depressive symptoms and either MnBP or MBzP. When we evaluated the associations between phthalate metabolite concentrations and the SDGS-K subgroup, we found that affective and spiritual symptoms were significantly associated with DEHP metabolite concentrations.CONCLUSIONS: Our study suggests that DEHP exposure is associated with depressive symptoms, particularly, the affective and spiritual symptoms, among the elderly population.",

keywords = "Aged, Depression/epidemiology, Dibutyl Phthalate/urine, Diethylhexyl Phthalate/urine, Environmental Exposure/statistics & numerical data, Environmental Pollutants/urine, Female, Humans, Male, Phthalic Acids/urine",

author = "Kyung-Shin Lee and Youn-Hee Lim and Kyoung-Nam Kim and Yoon-Hyeong Choi and Yun-Chul Hong and Nami Lee",

year = "2018",

doi = "10.1016/j.scitotenv.2017.12.219",

language = "English",

volume = "625",

pages = "1191--1197",

journal = "Science of the Total Environment",

issn = "0048-9697",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Urinary phthalate metabolites concentrations and symptoms of depression in an elderly population

AU - Lee, Kyung-Shin

AU - Lim, Youn-Hee

AU - Kim, Kyoung-Nam

AU - Choi, Yoon-Hyeong

AU - Hong, Yun-Chul

AU - Lee, Nami

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Animal studies have reported an association between phthalates and depression, although there is limited evidence from epidemiological studies. We investigated the association between phthalate exposure and symptoms of depression in an elderly population.METHODS: Repeated measures surveys up to three times were conducted during the study period (2012-2014) in the 535 elderly subjects. We measured the following urinary phthalate metabolite levels: mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-n-butyl phthalate (MnBP), and mono-benzyl phthalate (MBzP). MEHHP, MEOHP, and MECPP are metabolites of diethylhexyl phthalates (DEHP). MnBP and MBzP are metabolites of dibutyl phthalate and butyl benzyl phthalate, respectively. The phthalate metabolite concentrations were evaluated to identify associations with the symptoms of depression using the Korean version of the Geriatric Depression Scale-Short Form (SGDS-K). After factor analysis of the components of SGDS-K, we evaluated the association between phthalate exposure and SGDS-K subgroups to determine which symptoms of depression were affected by phthalate exposure.RESULTS: Concentrations of DEHP metabolites were positively associated with the risk of depressive symptoms in the elderly population (Odds ratio (95% confidence interval); 1.92 (1.17-3.13) for sum of three DEHP metabolites), while we found no significant association between depressive symptoms and either MnBP or MBzP. When we evaluated the associations between phthalate metabolite concentrations and the SDGS-K subgroup, we found that affective and spiritual symptoms were significantly associated with DEHP metabolite concentrations.CONCLUSIONS: Our study suggests that DEHP exposure is associated with depressive symptoms, particularly, the affective and spiritual symptoms, among the elderly population.

AB - BACKGROUND: Animal studies have reported an association between phthalates and depression, although there is limited evidence from epidemiological studies. We investigated the association between phthalate exposure and symptoms of depression in an elderly population.METHODS: Repeated measures surveys up to three times were conducted during the study period (2012-2014) in the 535 elderly subjects. We measured the following urinary phthalate metabolite levels: mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-n-butyl phthalate (MnBP), and mono-benzyl phthalate (MBzP). MEHHP, MEOHP, and MECPP are metabolites of diethylhexyl phthalates (DEHP). MnBP and MBzP are metabolites of dibutyl phthalate and butyl benzyl phthalate, respectively. The phthalate metabolite concentrations were evaluated to identify associations with the symptoms of depression using the Korean version of the Geriatric Depression Scale-Short Form (SGDS-K). After factor analysis of the components of SGDS-K, we evaluated the association between phthalate exposure and SGDS-K subgroups to determine which symptoms of depression were affected by phthalate exposure.RESULTS: Concentrations of DEHP metabolites were positively associated with the risk of depressive symptoms in the elderly population (Odds ratio (95% confidence interval); 1.92 (1.17-3.13) for sum of three DEHP metabolites), while we found no significant association between depressive symptoms and either MnBP or MBzP. When we evaluated the associations between phthalate metabolite concentrations and the SDGS-K subgroup, we found that affective and spiritual symptoms were significantly associated with DEHP metabolite concentrations.CONCLUSIONS: Our study suggests that DEHP exposure is associated with depressive symptoms, particularly, the affective and spiritual symptoms, among the elderly population.

KW - Aged

KW - Depression/epidemiology

KW - Dibutyl Phthalate/urine

KW - Diethylhexyl Phthalate/urine

KW - Environmental Exposure/statistics & numerical data

KW - Environmental Pollutants/urine

KW - Female

KW - Humans

KW - Male

KW - Phthalic Acids/urine

U2 - 10.1016/j.scitotenv.2017.12.219

DO - 10.1016/j.scitotenv.2017.12.219

M3 - Journal article

C2 - 29996415

VL - 625

SP - 1191

EP - 1197

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

ER -

ID: 230067522