TY - JOUR

T1 - Time trends in incidence and prevalence of chronic pancreatitis

T2 - A 25-year population-based nationwide study

AU - Olesen, Søren S.

AU - Mortensen, Laust H.

AU - Zinck, Elisabeth

AU - Becker, Ulrik

AU - Drewes, Asbjørn M.

AU - Nøjgaard, Camilla

AU - Novovic, Srdan

AU - Yadav, Dhiraj

AU - Tolstrup, Janne S.

PY - 2021

Y1 - 2021

N2 - Background: Updated population-based estimates on incidence and prevalence of chronic pancreatitis are scarce. Methods: We used nationwide healthcare registries to identify all Danish patients diagnosed with chronic pancreatitis and computed crude and standardised incidence rates and prevalence estimates in 1994–2018. Incidence and prevalence were evaluated in relation to patients age and gender, aetiology (alcoholic vs non-alcoholic) and smoking and alcohol consumption in the general Danish population. Results: The mean incidence rate of chronic pancreatitis during the study period was 12.6 per 100,000 person years for the total population, for women it was 8.6 per 100,000 person years and for men it was 16.7 per 100,000 person years. The standardised incidence rate was stable from from 1994 through 2018, remaining at 12.5 per 100,000 person years in the last observation period (2014–2018). The point prevalence of chronic pancreatitis in 2016 was 153.9 per 100,000 persons. A gradual increase in standardised prevalence estimates was observed during the study period from 126.6 in 1996 to 153.9 in 2016. The mean age at chronic pancreatitis diagnosis increased from 52.1 to 60.0 years during the study period. Conclusion: The prevalence of chronic pancreatitis is increasing in the Danish population despite a stable incidence level. Improved management strategies and changes in the underlying patient population may explain these observations.

AB - Background: Updated population-based estimates on incidence and prevalence of chronic pancreatitis are scarce. Methods: We used nationwide healthcare registries to identify all Danish patients diagnosed with chronic pancreatitis and computed crude and standardised incidence rates and prevalence estimates in 1994–2018. Incidence and prevalence were evaluated in relation to patients age and gender, aetiology (alcoholic vs non-alcoholic) and smoking and alcohol consumption in the general Danish population. Results: The mean incidence rate of chronic pancreatitis during the study period was 12.6 per 100,000 person years for the total population, for women it was 8.6 per 100,000 person years and for men it was 16.7 per 100,000 person years. The standardised incidence rate was stable from from 1994 through 2018, remaining at 12.5 per 100,000 person years in the last observation period (2014–2018). The point prevalence of chronic pancreatitis in 2016 was 153.9 per 100,000 persons. A gradual increase in standardised prevalence estimates was observed during the study period from 126.6 in 1996 to 153.9 in 2016. The mean age at chronic pancreatitis diagnosis increased from 52.1 to 60.0 years during the study period. Conclusion: The prevalence of chronic pancreatitis is increasing in the Danish population despite a stable incidence level. Improved management strategies and changes in the underlying patient population may explain these observations.

KW - alcohol

KW - Chronic pancreatitis

KW - epidemiology

KW - incidence

KW - prevalence

KW - smoking

U2 - 10.1177/2050640620966513

DO - 10.1177/2050640620966513

M3 - Journal article

C2 - 33176616

AN - SCOPUS:85095946519

VL - 9

SP - 82

EP - 90

JO - United European Gastroenterology Journal

JF - United European Gastroenterology Journal

SN - 2050-6406

IS - 1

ER -