The Relationship between Perfluoroalkyl Substances Concentrations and Thyroid Function in Early Childhood: A Prospective Cohort Study

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The Relationship between Perfluoroalkyl Substances Concentrations and Thyroid Function in Early Childhood : A Prospective Cohort Study. / Kim, Hwa Young; Kim, Kyoung-Nam; Shin, Choong Ho; Lim, Youn-Hee; Kim, Johanna Inhyang; Kim, Bung-Nyun; Hong, Yun-Chul; Lee, Young Ah.

I: Thyroid, Bind 30, Nr. 11, 05.05.2021.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Kim, HY, Kim, K-N, Shin, CH, Lim, Y-H, Kim, JI, Kim, B-N, Hong, Y-C & Lee, YA 2021, 'The Relationship between Perfluoroalkyl Substances Concentrations and Thyroid Function in Early Childhood: A Prospective Cohort Study', Thyroid, bind 30, nr. 11. https://doi.org/10.1089/thy.2019.0436

APA

Kim, H. Y., Kim, K-N., Shin, C. H., Lim, Y-H., Kim, J. I., Kim, B-N., Hong, Y-C., & Lee, Y. A. (2021). The Relationship between Perfluoroalkyl Substances Concentrations and Thyroid Function in Early Childhood: A Prospective Cohort Study. Thyroid, 30(11). https://doi.org/10.1089/thy.2019.0436

Vancouver

Kim HY, Kim K-N, Shin CH, Lim Y-H, Kim JI, Kim B-N o.a. The Relationship between Perfluoroalkyl Substances Concentrations and Thyroid Function in Early Childhood: A Prospective Cohort Study. Thyroid. 2021 maj 5;30(11). https://doi.org/10.1089/thy.2019.0436

Author

Kim, Hwa Young ; Kim, Kyoung-Nam ; Shin, Choong Ho ; Lim, Youn-Hee ; Kim, Johanna Inhyang ; Kim, Bung-Nyun ; Hong, Yun-Chul ; Lee, Young Ah. / The Relationship between Perfluoroalkyl Substances Concentrations and Thyroid Function in Early Childhood : A Prospective Cohort Study. I: Thyroid. 2021 ; Bind 30, Nr. 11.

Bibtex

@article{a2cee74838d341a7a821b6a835daf69a,
title = "The Relationship between Perfluoroalkyl Substances Concentrations and Thyroid Function in Early Childhood: A Prospective Cohort Study",
abstract = "BACKGROUND: Exposure to perfluoroalkyl substances (PFAS) has been suggested to affect thyroid function; however, data on early-life exposure and thyroid function in early childhood are scarce. We investigated the cross-sectional and longitudinal relationships of early-life exposure to PFAS with thyroid function at 2, 4, and 6 years of age.METHODS: This study used data on PFAS exposure and thyroid function from the Environment and Development of Children (EDC) cohort study. A total of 660 children who visited at least once at 2, 4, or 6 years of age (381 children aged 2 years, 569 children aged 4 years, and 511 children aged 6 years) were included in this study. Serum thyroid-stimulating hormone (TSH) levels were measured at 2, 4, and 6 years of age. The relationship of serum PFAS concentrations (sPFAS) with TSH levels at the 3 time points was assessed by repeated-measure analysis using linear mixed models. The serum levels of free thyroxine (FT4) and triiodothyronine (T3) were measured once (at 6 years of age). The relationship of sPFAS with FT4 and T3 levels at 6 years of age was investigated by linear regression analyses.RESULTS: None complained of hyper- or hypothyroid symptoms with normal FT4 and T3 levels. Repeated-measure analysis showed that TSH levels at ages 2, 4, and 6 years of age were inversely associated with sPFNA, after adjusting for age, sex, and/or dietary iodine intake (p<0.05). When stratified by sex, TSH levels were inversely associated with sPFOA in boys and sPFNA in girls (p<0.05 for both). FT4 levels at 6 years of age were positively related to sPFNA and sPFHxS at 2 years of age and sPFOA at 6 years of age, and T3 levels at 6 years of age showed positive relationships with sPFDA and sPFOS at 6 years of age (p<0.05 for all). When stratified by sex, similar positive relationships for sPFAS with FT4 and T3 levels were significant among boys only.CONCLUSIONS: A significant relationship was found between early-life exposure to PFAS and thyroid function. Early-life exposure to PFAS was associated with decreased TSH and increased FT4 or T3 levels among preschool-age children.",
author = "Kim, {Hwa Young} and Kyoung-Nam Kim and Shin, {Choong Ho} and Youn-Hee Lim and Kim, {Johanna Inhyang} and Bung-Nyun Kim and Yun-Chul Hong and Lee, {Young Ah}",
year = "2021",
month = may,
day = "5",
doi = "10.1089/thy.2019.0436",
language = "English",
volume = "30",
journal = "Thyroid",
issn = "1050-7256",
publisher = "Mary AnnLiebert, Inc. Publishers",
number = "11",

}

RIS

TY - JOUR

T1 - The Relationship between Perfluoroalkyl Substances Concentrations and Thyroid Function in Early Childhood

T2 - A Prospective Cohort Study

AU - Kim, Hwa Young

AU - Kim, Kyoung-Nam

AU - Shin, Choong Ho

AU - Lim, Youn-Hee

AU - Kim, Johanna Inhyang

AU - Kim, Bung-Nyun

AU - Hong, Yun-Chul

AU - Lee, Young Ah

PY - 2021/5/5

Y1 - 2021/5/5

N2 - BACKGROUND: Exposure to perfluoroalkyl substances (PFAS) has been suggested to affect thyroid function; however, data on early-life exposure and thyroid function in early childhood are scarce. We investigated the cross-sectional and longitudinal relationships of early-life exposure to PFAS with thyroid function at 2, 4, and 6 years of age.METHODS: This study used data on PFAS exposure and thyroid function from the Environment and Development of Children (EDC) cohort study. A total of 660 children who visited at least once at 2, 4, or 6 years of age (381 children aged 2 years, 569 children aged 4 years, and 511 children aged 6 years) were included in this study. Serum thyroid-stimulating hormone (TSH) levels were measured at 2, 4, and 6 years of age. The relationship of serum PFAS concentrations (sPFAS) with TSH levels at the 3 time points was assessed by repeated-measure analysis using linear mixed models. The serum levels of free thyroxine (FT4) and triiodothyronine (T3) were measured once (at 6 years of age). The relationship of sPFAS with FT4 and T3 levels at 6 years of age was investigated by linear regression analyses.RESULTS: None complained of hyper- or hypothyroid symptoms with normal FT4 and T3 levels. Repeated-measure analysis showed that TSH levels at ages 2, 4, and 6 years of age were inversely associated with sPFNA, after adjusting for age, sex, and/or dietary iodine intake (p<0.05). When stratified by sex, TSH levels were inversely associated with sPFOA in boys and sPFNA in girls (p<0.05 for both). FT4 levels at 6 years of age were positively related to sPFNA and sPFHxS at 2 years of age and sPFOA at 6 years of age, and T3 levels at 6 years of age showed positive relationships with sPFDA and sPFOS at 6 years of age (p<0.05 for all). When stratified by sex, similar positive relationships for sPFAS with FT4 and T3 levels were significant among boys only.CONCLUSIONS: A significant relationship was found between early-life exposure to PFAS and thyroid function. Early-life exposure to PFAS was associated with decreased TSH and increased FT4 or T3 levels among preschool-age children.

AB - BACKGROUND: Exposure to perfluoroalkyl substances (PFAS) has been suggested to affect thyroid function; however, data on early-life exposure and thyroid function in early childhood are scarce. We investigated the cross-sectional and longitudinal relationships of early-life exposure to PFAS with thyroid function at 2, 4, and 6 years of age.METHODS: This study used data on PFAS exposure and thyroid function from the Environment and Development of Children (EDC) cohort study. A total of 660 children who visited at least once at 2, 4, or 6 years of age (381 children aged 2 years, 569 children aged 4 years, and 511 children aged 6 years) were included in this study. Serum thyroid-stimulating hormone (TSH) levels were measured at 2, 4, and 6 years of age. The relationship of serum PFAS concentrations (sPFAS) with TSH levels at the 3 time points was assessed by repeated-measure analysis using linear mixed models. The serum levels of free thyroxine (FT4) and triiodothyronine (T3) were measured once (at 6 years of age). The relationship of sPFAS with FT4 and T3 levels at 6 years of age was investigated by linear regression analyses.RESULTS: None complained of hyper- or hypothyroid symptoms with normal FT4 and T3 levels. Repeated-measure analysis showed that TSH levels at ages 2, 4, and 6 years of age were inversely associated with sPFNA, after adjusting for age, sex, and/or dietary iodine intake (p<0.05). When stratified by sex, TSH levels were inversely associated with sPFOA in boys and sPFNA in girls (p<0.05 for both). FT4 levels at 6 years of age were positively related to sPFNA and sPFHxS at 2 years of age and sPFOA at 6 years of age, and T3 levels at 6 years of age showed positive relationships with sPFDA and sPFOS at 6 years of age (p<0.05 for all). When stratified by sex, similar positive relationships for sPFAS with FT4 and T3 levels were significant among boys only.CONCLUSIONS: A significant relationship was found between early-life exposure to PFAS and thyroid function. Early-life exposure to PFAS was associated with decreased TSH and increased FT4 or T3 levels among preschool-age children.

U2 - 10.1089/thy.2019.0436

DO - 10.1089/thy.2019.0436

M3 - Journal article

C2 - 32368952

VL - 30

JO - Thyroid

JF - Thyroid

SN - 1050-7256

IS - 11

ER -

ID: 241093313