The importance of early life family factors in the association between cardiovascular risk factors and early cardiovascular mortality

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

The importance of early life family factors in the association between cardiovascular risk factors and early cardiovascular mortality. / Kjøllesdal, Marte K.R.; Ariansen, Inger; Mortensen, Laust H.; Næss, Øyvind.

I: Open Heart, Bind 4, Nr. 2, e000608, 2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Kjøllesdal, MKR, Ariansen, I, Mortensen, LH & Næss, Ø 2017, 'The importance of early life family factors in the association between cardiovascular risk factors and early cardiovascular mortality', Open Heart, bind 4, nr. 2, e000608. https://doi.org/10.1136/openhrt-2017-000608

APA

Kjøllesdal, M. K. R., Ariansen, I., Mortensen, L. H., & Næss, Ø. (2017). The importance of early life family factors in the association between cardiovascular risk factors and early cardiovascular mortality. Open Heart, 4(2), [e000608]. https://doi.org/10.1136/openhrt-2017-000608

Vancouver

Kjøllesdal MKR, Ariansen I, Mortensen LH, Næss Ø. The importance of early life family factors in the association between cardiovascular risk factors and early cardiovascular mortality. Open Heart. 2017;4(2). e000608. https://doi.org/10.1136/openhrt-2017-000608

Author

Kjøllesdal, Marte K.R. ; Ariansen, Inger ; Mortensen, Laust H. ; Næss, Øyvind. / The importance of early life family factors in the association between cardiovascular risk factors and early cardiovascular mortality. I: Open Heart. 2017 ; Bind 4, Nr. 2.

Bibtex

@article{24154c75436642d688e3459c4bcedd23,
title = "The importance of early life family factors in the association between cardiovascular risk factors and early cardiovascular mortality",
abstract = "Objective To explore the importance of early life factors shared by siblings, such as parental socioeconomic position, parental practices, housing and neighbourhood, for the association between cardiovascular disease (CVD) risk factors and mortality from CVD, ischaemic heart disease (IHD) and cerebrovascular disease. Methods Norwegian health surveys (1974-2003) were linked with data from the Norwegian Family Based Life Course Study and the Cause of Death Registry. Participants with at least one full sibling among survey participants (n=2 71 643) were included. Data on CVD risk factors, body mass index (BMI), height, systolic blood pressure (SBP) and total cholesterol (TC) were stratified into 'low', 'medium' and 'high' risk, and smoking to 'daily smoking' and 'not daily smoking'. Results Mean age of participants was 41 years, mean follow-up time was 19 years and during follow-up 2512 died from CVD. For each category of increased risk factor level, the per step HR of CVD mortality was increased by 1.91 (95% CI 1.78 to 2.05) for SBP, 1.67 (1.58 to 1.76) for TC, 1.44 (1.36 to 1.53) for BMI, 1.26 (1.18 to 1.35) for height and 2.89 (2.66 to 3.14) for smoking. In analyses where each sibship (groups of full siblings) had a group-specific baseline hazard, these associations were attenuated to 1.74, 1.51, 1.29, 1.18 and 2.63, respectively. The associations between risk factors and IHD mortality followed the same pattern. Conclusion Early life family factors explained a small part of the association between risk factors and mortality from CVD and IHD in a relatively young sample.",
keywords = "epidemiology, public health, risk factors",
author = "Kj{\o}llesdal, {Marte K.R.} and Inger Ariansen and Mortensen, {Laust H.} and {\O}yvind N{\ae}ss",
year = "2017",
doi = "10.1136/openhrt-2017-000608",
language = "English",
volume = "4",
journal = "Open Heart",
issn = "2398-595X",
publisher = "BMJ",
number = "2",

}

RIS

TY - JOUR

T1 - The importance of early life family factors in the association between cardiovascular risk factors and early cardiovascular mortality

AU - Kjøllesdal, Marte K.R.

AU - Ariansen, Inger

AU - Mortensen, Laust H.

AU - Næss, Øyvind

PY - 2017

Y1 - 2017

N2 - Objective To explore the importance of early life factors shared by siblings, such as parental socioeconomic position, parental practices, housing and neighbourhood, for the association between cardiovascular disease (CVD) risk factors and mortality from CVD, ischaemic heart disease (IHD) and cerebrovascular disease. Methods Norwegian health surveys (1974-2003) were linked with data from the Norwegian Family Based Life Course Study and the Cause of Death Registry. Participants with at least one full sibling among survey participants (n=2 71 643) were included. Data on CVD risk factors, body mass index (BMI), height, systolic blood pressure (SBP) and total cholesterol (TC) were stratified into 'low', 'medium' and 'high' risk, and smoking to 'daily smoking' and 'not daily smoking'. Results Mean age of participants was 41 years, mean follow-up time was 19 years and during follow-up 2512 died from CVD. For each category of increased risk factor level, the per step HR of CVD mortality was increased by 1.91 (95% CI 1.78 to 2.05) for SBP, 1.67 (1.58 to 1.76) for TC, 1.44 (1.36 to 1.53) for BMI, 1.26 (1.18 to 1.35) for height and 2.89 (2.66 to 3.14) for smoking. In analyses where each sibship (groups of full siblings) had a group-specific baseline hazard, these associations were attenuated to 1.74, 1.51, 1.29, 1.18 and 2.63, respectively. The associations between risk factors and IHD mortality followed the same pattern. Conclusion Early life family factors explained a small part of the association between risk factors and mortality from CVD and IHD in a relatively young sample.

AB - Objective To explore the importance of early life factors shared by siblings, such as parental socioeconomic position, parental practices, housing and neighbourhood, for the association between cardiovascular disease (CVD) risk factors and mortality from CVD, ischaemic heart disease (IHD) and cerebrovascular disease. Methods Norwegian health surveys (1974-2003) were linked with data from the Norwegian Family Based Life Course Study and the Cause of Death Registry. Participants with at least one full sibling among survey participants (n=2 71 643) were included. Data on CVD risk factors, body mass index (BMI), height, systolic blood pressure (SBP) and total cholesterol (TC) were stratified into 'low', 'medium' and 'high' risk, and smoking to 'daily smoking' and 'not daily smoking'. Results Mean age of participants was 41 years, mean follow-up time was 19 years and during follow-up 2512 died from CVD. For each category of increased risk factor level, the per step HR of CVD mortality was increased by 1.91 (95% CI 1.78 to 2.05) for SBP, 1.67 (1.58 to 1.76) for TC, 1.44 (1.36 to 1.53) for BMI, 1.26 (1.18 to 1.35) for height and 2.89 (2.66 to 3.14) for smoking. In analyses where each sibship (groups of full siblings) had a group-specific baseline hazard, these associations were attenuated to 1.74, 1.51, 1.29, 1.18 and 2.63, respectively. The associations between risk factors and IHD mortality followed the same pattern. Conclusion Early life family factors explained a small part of the association between risk factors and mortality from CVD and IHD in a relatively young sample.

KW - epidemiology

KW - public health

KW - risk factors

U2 - 10.1136/openhrt-2017-000608

DO - 10.1136/openhrt-2017-000608

M3 - Journal article

C2 - 28878947

AN - SCOPUS:85027164513

VL - 4

JO - Open Heart

JF - Open Heart

SN - 2398-595X

IS - 2

M1 - e000608

ER -

ID: 197803255