The impact of the trajectory of bipolar disorder on global cognitive function: A one-year clinical prospective case-control study

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The impact of the trajectory of bipolar disorder on global cognitive function : A one-year clinical prospective case-control study. / Knorr, Ulla; Miskowiak, Kamilla; Akhøj, Morten; Vinberg, Maj; Forman, Julie; Kessing, Lars Vedel.

I: Journal of Affective Disorders, Bind 278, 01.01.2021, s. 189-198.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Knorr, U, Miskowiak, K, Akhøj, M, Vinberg, M, Forman, J & Kessing, LV 2021, 'The impact of the trajectory of bipolar disorder on global cognitive function: A one-year clinical prospective case-control study', Journal of Affective Disorders, bind 278, s. 189-198. https://doi.org/10.1016/j.jad.2020.09.055

APA

Knorr, U., Miskowiak, K., Akhøj, M., Vinberg, M., Forman, J., & Kessing, L. V. (2021). The impact of the trajectory of bipolar disorder on global cognitive function: A one-year clinical prospective case-control study. Journal of Affective Disorders, 278, 189-198. https://doi.org/10.1016/j.jad.2020.09.055

Vancouver

Knorr U, Miskowiak K, Akhøj M, Vinberg M, Forman J, Kessing LV. The impact of the trajectory of bipolar disorder on global cognitive function: A one-year clinical prospective case-control study. Journal of Affective Disorders. 2021 jan 1;278:189-198. https://doi.org/10.1016/j.jad.2020.09.055

Author

Knorr, Ulla ; Miskowiak, Kamilla ; Akhøj, Morten ; Vinberg, Maj ; Forman, Julie ; Kessing, Lars Vedel. / The impact of the trajectory of bipolar disorder on global cognitive function : A one-year clinical prospective case-control study. I: Journal of Affective Disorders. 2021 ; Bind 278. s. 189-198.

Bibtex

@article{c22d199b6af24120a480b82b526477c8,
title = "The impact of the trajectory of bipolar disorder on global cognitive function: A one-year clinical prospective case-control study",
abstract = "Background: The relationship between cognitive function and relapse of affective episodes in bipolar disorder (BD) is rarely studied. The aim of this prospective, longitudinal, case-control study was to assess the trajectory of cognitive function and mood occilations within a one-year period in patients with BD relative to healthy control (HC) individuals. Methods: The sample included 86 outpatients with BD in euthymia, and 44 gender-and-age-matched HC. All participants were evaluated with clinical assessement and neuropsychological testing at baseline and during euthymia after a year. Further patients with BD were reevaluated if they developed a new affective episode during follow-up. The patients´ affective states were recorded on a weekly basis as asymptomatic, subthreshold level, major depression or (hypo)mania. Cognitive changes over time were measured for a global cognitive score and for the four cognitive domains: {\textquoteleft}working memory and executive skills{\textquoteright}, {\textquoteleft}psychomotor speed{\textquoteright}, {\textquoteleft}sustained attention{\textquoteright}, and {\textquoteleft}verbal learning and memory{\textquoteright} in patients and HC. Results: The study showed that cognitive performance in patients with BD was unaltered compared to baseline when they stabilised in euthymia following an affective episode and, at the one-year follow-up. Cognitive performance showed practice effect, thus improved within a year across patients with BD and HC. Furthermore, cognitive functions were not related to clinical subtypes BDI/II, prior psychosis, the polarity of the relapse and week-to-week mood fluctuations during follow-up. Functioning correlated weakly to moderately with week-to-week mood fluctuations. Limitations: Modest sample size. Conclusion: A one-year trajectory of BD seems to have no direct negative impact on cognitive function.",
keywords = "Bipolar disorder, Case-control, Cognitive function, Prospective",
author = "Ulla Knorr and Kamilla Miskowiak and Morten Akh{\o}j and Maj Vinberg and Julie Forman and Kessing, {Lars Vedel}",
year = "2021",
month = jan,
day = "1",
doi = "10.1016/j.jad.2020.09.055",
language = "English",
volume = "278",
pages = "189--198",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The impact of the trajectory of bipolar disorder on global cognitive function

T2 - A one-year clinical prospective case-control study

AU - Knorr, Ulla

AU - Miskowiak, Kamilla

AU - Akhøj, Morten

AU - Vinberg, Maj

AU - Forman, Julie

AU - Kessing, Lars Vedel

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Background: The relationship between cognitive function and relapse of affective episodes in bipolar disorder (BD) is rarely studied. The aim of this prospective, longitudinal, case-control study was to assess the trajectory of cognitive function and mood occilations within a one-year period in patients with BD relative to healthy control (HC) individuals. Methods: The sample included 86 outpatients with BD in euthymia, and 44 gender-and-age-matched HC. All participants were evaluated with clinical assessement and neuropsychological testing at baseline and during euthymia after a year. Further patients with BD were reevaluated if they developed a new affective episode during follow-up. The patients´ affective states were recorded on a weekly basis as asymptomatic, subthreshold level, major depression or (hypo)mania. Cognitive changes over time were measured for a global cognitive score and for the four cognitive domains: ‘working memory and executive skills’, ‘psychomotor speed’, ‘sustained attention’, and ‘verbal learning and memory’ in patients and HC. Results: The study showed that cognitive performance in patients with BD was unaltered compared to baseline when they stabilised in euthymia following an affective episode and, at the one-year follow-up. Cognitive performance showed practice effect, thus improved within a year across patients with BD and HC. Furthermore, cognitive functions were not related to clinical subtypes BDI/II, prior psychosis, the polarity of the relapse and week-to-week mood fluctuations during follow-up. Functioning correlated weakly to moderately with week-to-week mood fluctuations. Limitations: Modest sample size. Conclusion: A one-year trajectory of BD seems to have no direct negative impact on cognitive function.

AB - Background: The relationship between cognitive function and relapse of affective episodes in bipolar disorder (BD) is rarely studied. The aim of this prospective, longitudinal, case-control study was to assess the trajectory of cognitive function and mood occilations within a one-year period in patients with BD relative to healthy control (HC) individuals. Methods: The sample included 86 outpatients with BD in euthymia, and 44 gender-and-age-matched HC. All participants were evaluated with clinical assessement and neuropsychological testing at baseline and during euthymia after a year. Further patients with BD were reevaluated if they developed a new affective episode during follow-up. The patients´ affective states were recorded on a weekly basis as asymptomatic, subthreshold level, major depression or (hypo)mania. Cognitive changes over time were measured for a global cognitive score and for the four cognitive domains: ‘working memory and executive skills’, ‘psychomotor speed’, ‘sustained attention’, and ‘verbal learning and memory’ in patients and HC. Results: The study showed that cognitive performance in patients with BD was unaltered compared to baseline when they stabilised in euthymia following an affective episode and, at the one-year follow-up. Cognitive performance showed practice effect, thus improved within a year across patients with BD and HC. Furthermore, cognitive functions were not related to clinical subtypes BDI/II, prior psychosis, the polarity of the relapse and week-to-week mood fluctuations during follow-up. Functioning correlated weakly to moderately with week-to-week mood fluctuations. Limitations: Modest sample size. Conclusion: A one-year trajectory of BD seems to have no direct negative impact on cognitive function.

KW - Bipolar disorder

KW - Case-control

KW - Cognitive function

KW - Prospective

U2 - 10.1016/j.jad.2020.09.055

DO - 10.1016/j.jad.2020.09.055

M3 - Journal article

C2 - 32961415

AN - SCOPUS:85091076027

VL - 278

SP - 189

EP - 198

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 254468449