The familial and genetic contribution to the association between depression and cardiovascular disease: a twin cohort study

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The familial and genetic contribution to the association between depression and cardiovascular disease : a twin cohort study. / Wium-Andersen, Marie Kim; Villumsen, Martin Dalgaard; Wium-Andersen, Ida Kim; Jorgensen, Martin Balslev; Hjelmborg, Jacob von Bornemann; Christensen, Kaare; Osler, Merete.

I: Molecular Psychiatry, Bind 26, 2021, s. 4245–4253.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Wium-Andersen, MK, Villumsen, MD, Wium-Andersen, IK, Jorgensen, MB, Hjelmborg, JVB, Christensen, K & Osler, M 2021, 'The familial and genetic contribution to the association between depression and cardiovascular disease: a twin cohort study', Molecular Psychiatry, bind 26, s. 4245–4253. https://doi.org/10.1038/s41380-020-00954-6

APA

Wium-Andersen, M. K., Villumsen, M. D., Wium-Andersen, I. K., Jorgensen, M. B., Hjelmborg, J. V. B., Christensen, K., & Osler, M. (2021). The familial and genetic contribution to the association between depression and cardiovascular disease: a twin cohort study. Molecular Psychiatry, 26, 4245–4253. https://doi.org/10.1038/s41380-020-00954-6

Vancouver

Wium-Andersen MK, Villumsen MD, Wium-Andersen IK, Jorgensen MB, Hjelmborg JVB, Christensen K o.a. The familial and genetic contribution to the association between depression and cardiovascular disease: a twin cohort study. Molecular Psychiatry. 2021;26:4245–4253. https://doi.org/10.1038/s41380-020-00954-6

Author

Wium-Andersen, Marie Kim ; Villumsen, Martin Dalgaard ; Wium-Andersen, Ida Kim ; Jorgensen, Martin Balslev ; Hjelmborg, Jacob von Bornemann ; Christensen, Kaare ; Osler, Merete. / The familial and genetic contribution to the association between depression and cardiovascular disease : a twin cohort study. I: Molecular Psychiatry. 2021 ; Bind 26. s. 4245–4253.

Bibtex

@article{b79a908b5a6c481e836bc654af4af47f,
title = "The familial and genetic contribution to the association between depression and cardiovascular disease: a twin cohort study",
abstract = "Depression and cardiovascular disease (ischemic heart disease and stroke) are associated in a bidirectional manner. Their relatively high heritability has led to the hypothesis that this co-occurrence is related to shared familial and genetic factors; this study aims to test this hypothesis. We included 23,498 monozygotic and 39,540 same-sex dizygotic twins from the Danish Twin Registry followed from January 1977 until December 2011 in nationwide Danish registries. We used survival analyses accounting for censoring and competing risk of death to estimate cumulative incidence, casewise concordance, relative recurrence risk, and heritability of the co-occurrence of depression and cardiovascular disease by age using monozygotic and same-sex dizygotic twin pairs. The casewise concordance of ischemic heart disease or stroke in twins whose co-twin was diagnosed with depression was at all ages similar for the monozygotic and dizygotic twin pairs and to the cumulative incidence of ischemic heart disease or stroke, respectively, in the entire twin population. A similar pattern was seen in analyses of depression risk given the co-twin being diagnosed with ischemic heart disease or stroke. Relative recurrence risk and heritability estimates were also of modest size and with confidence intervals including unity. Results were similar after stratification by gender as well as when redefining depression to include the use of antidepressant medication from 1995. Our findings do not support that co-occurrence between depression and cardiovascular disease is explainable by shared genetic factors, nor did we find strong evidence of a familial effect.",
keywords = "CORONARY-ARTERY-DISEASE, HEART-DISEASE, DISCHARGE DIAGNOSES, MAJOR DEPRESSION, HERITABILITY, REGISTRY, SYMPTOMS, EPIDEMIOLOGY, INFLAMMATION, PATHWAYS",
author = "Wium-Andersen, {Marie Kim} and Villumsen, {Martin Dalgaard} and Wium-Andersen, {Ida Kim} and Jorgensen, {Martin Balslev} and Hjelmborg, {Jacob von Bornemann} and Kaare Christensen and Merete Osler",
year = "2021",
doi = "10.1038/s41380-020-00954-6",
language = "English",
volume = "26",
pages = "4245–4253",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - The familial and genetic contribution to the association between depression and cardiovascular disease

T2 - a twin cohort study

AU - Wium-Andersen, Marie Kim

AU - Villumsen, Martin Dalgaard

AU - Wium-Andersen, Ida Kim

AU - Jorgensen, Martin Balslev

AU - Hjelmborg, Jacob von Bornemann

AU - Christensen, Kaare

AU - Osler, Merete

PY - 2021

Y1 - 2021

N2 - Depression and cardiovascular disease (ischemic heart disease and stroke) are associated in a bidirectional manner. Their relatively high heritability has led to the hypothesis that this co-occurrence is related to shared familial and genetic factors; this study aims to test this hypothesis. We included 23,498 monozygotic and 39,540 same-sex dizygotic twins from the Danish Twin Registry followed from January 1977 until December 2011 in nationwide Danish registries. We used survival analyses accounting for censoring and competing risk of death to estimate cumulative incidence, casewise concordance, relative recurrence risk, and heritability of the co-occurrence of depression and cardiovascular disease by age using monozygotic and same-sex dizygotic twin pairs. The casewise concordance of ischemic heart disease or stroke in twins whose co-twin was diagnosed with depression was at all ages similar for the monozygotic and dizygotic twin pairs and to the cumulative incidence of ischemic heart disease or stroke, respectively, in the entire twin population. A similar pattern was seen in analyses of depression risk given the co-twin being diagnosed with ischemic heart disease or stroke. Relative recurrence risk and heritability estimates were also of modest size and with confidence intervals including unity. Results were similar after stratification by gender as well as when redefining depression to include the use of antidepressant medication from 1995. Our findings do not support that co-occurrence between depression and cardiovascular disease is explainable by shared genetic factors, nor did we find strong evidence of a familial effect.

AB - Depression and cardiovascular disease (ischemic heart disease and stroke) are associated in a bidirectional manner. Their relatively high heritability has led to the hypothesis that this co-occurrence is related to shared familial and genetic factors; this study aims to test this hypothesis. We included 23,498 monozygotic and 39,540 same-sex dizygotic twins from the Danish Twin Registry followed from January 1977 until December 2011 in nationwide Danish registries. We used survival analyses accounting for censoring and competing risk of death to estimate cumulative incidence, casewise concordance, relative recurrence risk, and heritability of the co-occurrence of depression and cardiovascular disease by age using monozygotic and same-sex dizygotic twin pairs. The casewise concordance of ischemic heart disease or stroke in twins whose co-twin was diagnosed with depression was at all ages similar for the monozygotic and dizygotic twin pairs and to the cumulative incidence of ischemic heart disease or stroke, respectively, in the entire twin population. A similar pattern was seen in analyses of depression risk given the co-twin being diagnosed with ischemic heart disease or stroke. Relative recurrence risk and heritability estimates were also of modest size and with confidence intervals including unity. Results were similar after stratification by gender as well as when redefining depression to include the use of antidepressant medication from 1995. Our findings do not support that co-occurrence between depression and cardiovascular disease is explainable by shared genetic factors, nor did we find strong evidence of a familial effect.

KW - CORONARY-ARTERY-DISEASE

KW - HEART-DISEASE

KW - DISCHARGE DIAGNOSES

KW - MAJOR DEPRESSION

KW - HERITABILITY

KW - REGISTRY

KW - SYMPTOMS

KW - EPIDEMIOLOGY

KW - INFLAMMATION

KW - PATHWAYS

U2 - 10.1038/s41380-020-00954-6

DO - 10.1038/s41380-020-00954-6

M3 - Journal article

C2 - 33219357

VL - 26

SP - 4245

EP - 4253

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

ER -

ID: 252591839