The effect of prenatal TVOC exposure on birth and infantile weight: the Mothers and Children's Environmental Health study
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The effect of prenatal TVOC exposure on birth and infantile weight : the Mothers and Children's Environmental Health study. / Chang, Moonhee; Park, Hyesook; Ha, Mina; Hong, Yun-Chul; Lim, Youn-Hee; Kim, Yangho; Kim, Young Ju; Lee, Dongheon; Ha, Eun-Hee.
I: Pediatric Research, Bind 82, Nr. 3, 2017, s. 423-428.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - The effect of prenatal TVOC exposure on birth and infantile weight
T2 - the Mothers and Children's Environmental Health study
AU - Chang, Moonhee
AU - Park, Hyesook
AU - Ha, Mina
AU - Hong, Yun-Chul
AU - Lim, Youn-Hee
AU - Kim, Yangho
AU - Kim, Young Ju
AU - Lee, Dongheon
AU - Ha, Eun-Hee
PY - 2017
Y1 - 2017
N2 - BACKGROUNDVolatile organic compounds (VOCs) might restrict prenatal and postnatal growth. However, the effect of the exposure of prenatal VOCs on postnatal growth has not been studied sufficiently. Thus, we investigated the relationship between the exposure of total volatile organic compounds (TVOCs) during pregnancy and its effects on postnatal growth.METHODSA total of 383 pregnant participants were enrolled from 2006 to 2008. We investigated maternal characteristics using a questionnaire. Personal air samples of TVOCs were obtained in mid or late pregnancy. After these mothers had given birth, 360 singleton newborns were selected and postnatal follow-up data were collected at 6, 12, 24, and 36 months, as well as anthropometric factors including body weight. Multiple general linear and mixed models were applied for statistical analyses.RESULTSThe mean concentration of prenatal exposure to TVOCs was 284.2 μg/m3 and that of formaldehyde was 81.6 μg/m3. The birth weight of newborns decreased significantly with prenatal TVOC exposure (β=-45.89, P=0.04). The adjusted mean body weight was 300 g lower in the high-TVOC group (⩾75th) compared with that in the low-exposure group (<75th).CONCLUSIONThese results indicate that elevated exposure to TVOCs during the prenatal period may adversely influence early postnatal growth.
AB - BACKGROUNDVolatile organic compounds (VOCs) might restrict prenatal and postnatal growth. However, the effect of the exposure of prenatal VOCs on postnatal growth has not been studied sufficiently. Thus, we investigated the relationship between the exposure of total volatile organic compounds (TVOCs) during pregnancy and its effects on postnatal growth.METHODSA total of 383 pregnant participants were enrolled from 2006 to 2008. We investigated maternal characteristics using a questionnaire. Personal air samples of TVOCs were obtained in mid or late pregnancy. After these mothers had given birth, 360 singleton newborns were selected and postnatal follow-up data were collected at 6, 12, 24, and 36 months, as well as anthropometric factors including body weight. Multiple general linear and mixed models were applied for statistical analyses.RESULTSThe mean concentration of prenatal exposure to TVOCs was 284.2 μg/m3 and that of formaldehyde was 81.6 μg/m3. The birth weight of newborns decreased significantly with prenatal TVOC exposure (β=-45.89, P=0.04). The adjusted mean body weight was 300 g lower in the high-TVOC group (⩾75th) compared with that in the low-exposure group (<75th).CONCLUSIONThese results indicate that elevated exposure to TVOCs during the prenatal period may adversely influence early postnatal growth.
KW - Adult
KW - Birth Weight/drug effects
KW - Body Weight
KW - Female
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Maternal Exposure
KW - Pregnancy
KW - Prospective Studies
KW - Volatile Organic Compounds/toxicity
U2 - 10.1038/pr.2017.55
DO - 10.1038/pr.2017.55
M3 - Journal article
C2 - 28422943
VL - 82
SP - 423
EP - 428
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 3
ER -
ID: 230069111