Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men. / Vestergaard, Mark Bitsch; Lindberg, Ulrich; Knudsen, Maria Højberg; Urdanibia-Centelles, Olalla; Bakhtiari, Aftab; Mortensen, Erik Lykke; Osler, Merete; Fagerlund, Birgitte; Benedek, Krisztina; Lauritzen, Martin; Larsson, Henrik Bo Wiberg.

I: GeroScience, Bind 44, 2022, s. 1905–1923.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Vestergaard, MB, Lindberg, U, Knudsen, MH, Urdanibia-Centelles, O, Bakhtiari, A, Mortensen, EL, Osler, M, Fagerlund, B, Benedek, K, Lauritzen, M & Larsson, HBW 2022, 'Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men', GeroScience, bind 44, s. 1905–1923. https://doi.org/10.1007/s11357-022-00596-2

APA

Vestergaard, M. B., Lindberg, U., Knudsen, M. H., Urdanibia-Centelles, O., Bakhtiari, A., Mortensen, E. L., Osler, M., Fagerlund, B., Benedek, K., Lauritzen, M., & Larsson, H. B. W. (2022). Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men. GeroScience, 44, 1905–1923. https://doi.org/10.1007/s11357-022-00596-2

Vancouver

Vestergaard MB, Lindberg U, Knudsen MH, Urdanibia-Centelles O, Bakhtiari A, Mortensen EL o.a. Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men. GeroScience. 2022;44:1905–1923. https://doi.org/10.1007/s11357-022-00596-2

Author

Vestergaard, Mark Bitsch ; Lindberg, Ulrich ; Knudsen, Maria Højberg ; Urdanibia-Centelles, Olalla ; Bakhtiari, Aftab ; Mortensen, Erik Lykke ; Osler, Merete ; Fagerlund, Birgitte ; Benedek, Krisztina ; Lauritzen, Martin ; Larsson, Henrik Bo Wiberg. / Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men. I: GeroScience. 2022 ; Bind 44. s. 1905–1923.

Bibtex

@article{0ecc375f28f74151a3ca3bd6cbeb3033,
title = "Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men",
abstract = "Reduced cerebrovascular response to neuronal activation is observed in patients with neurodegenerative disease. In the present study, we examined the correlation between reduced cerebrovascular response to visual activation (ΔCBFVis.Act) and subclinical cognitive deficits in a human population of mid-sixties individuals without neurodegenerative disease. Such a correlation would suggest that impaired cerebrovascular function occurs before overt neurodegenerative disease. A total of 187 subjects (age 64-67 years) of the Metropolit Danish Male Birth Cohort participated in the study. ΔCBFVis.Act was measured using arterial spin labelling (ASL) MRI. ΔCBFVis.Act correlated positively with cognitive performance in: Global cognition (p = 0.046), paired associative memory (p = 0.025), spatial recognition (p = 0.026), planning (p = 0.016), simple processing speed (p < 0.01), and with highly significant correlations with current intelligence (p < 10-5), and more complex processing speed (p < 10-3), the latter two explaining approximately 11-13% of the variance. Reduced ΔCBFVis.Act was independent of brain atrophy. Our findings suggest that inhibited cerebrovascular response to neuronal activation is an early deficit in the ageing brain and associated with subclinical cognitive deficits. Cerebrovascular dysfunction could be an early sign of a trajectory pointing towards the development of neurodegenerative disease. Future efforts should elucidate if maintenance of a healthy cerebrovascular function can protect against the development of dementia.",
author = "Vestergaard, {Mark Bitsch} and Ulrich Lindberg and Knudsen, {Maria H{\o}jberg} and Olalla Urdanibia-Centelles and Aftab Bakhtiari and Mortensen, {Erik Lykke} and Merete Osler and Birgitte Fagerlund and Krisztina Benedek and Martin Lauritzen and Larsson, {Henrik Bo Wiberg}",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
doi = "10.1007/s11357-022-00596-2",
language = "English",
volume = "44",
pages = "1905–1923",
journal = "GeroScience",
issn = "0161-9152",
publisher = "Springer Science+Business Media",

}

RIS

TY - JOUR

T1 - Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men

AU - Vestergaard, Mark Bitsch

AU - Lindberg, Ulrich

AU - Knudsen, Maria Højberg

AU - Urdanibia-Centelles, Olalla

AU - Bakhtiari, Aftab

AU - Mortensen, Erik Lykke

AU - Osler, Merete

AU - Fagerlund, Birgitte

AU - Benedek, Krisztina

AU - Lauritzen, Martin

AU - Larsson, Henrik Bo Wiberg

N1 - © 2022. The Author(s).

PY - 2022

Y1 - 2022

N2 - Reduced cerebrovascular response to neuronal activation is observed in patients with neurodegenerative disease. In the present study, we examined the correlation between reduced cerebrovascular response to visual activation (ΔCBFVis.Act) and subclinical cognitive deficits in a human population of mid-sixties individuals without neurodegenerative disease. Such a correlation would suggest that impaired cerebrovascular function occurs before overt neurodegenerative disease. A total of 187 subjects (age 64-67 years) of the Metropolit Danish Male Birth Cohort participated in the study. ΔCBFVis.Act was measured using arterial spin labelling (ASL) MRI. ΔCBFVis.Act correlated positively with cognitive performance in: Global cognition (p = 0.046), paired associative memory (p = 0.025), spatial recognition (p = 0.026), planning (p = 0.016), simple processing speed (p < 0.01), and with highly significant correlations with current intelligence (p < 10-5), and more complex processing speed (p < 10-3), the latter two explaining approximately 11-13% of the variance. Reduced ΔCBFVis.Act was independent of brain atrophy. Our findings suggest that inhibited cerebrovascular response to neuronal activation is an early deficit in the ageing brain and associated with subclinical cognitive deficits. Cerebrovascular dysfunction could be an early sign of a trajectory pointing towards the development of neurodegenerative disease. Future efforts should elucidate if maintenance of a healthy cerebrovascular function can protect against the development of dementia.

AB - Reduced cerebrovascular response to neuronal activation is observed in patients with neurodegenerative disease. In the present study, we examined the correlation between reduced cerebrovascular response to visual activation (ΔCBFVis.Act) and subclinical cognitive deficits in a human population of mid-sixties individuals without neurodegenerative disease. Such a correlation would suggest that impaired cerebrovascular function occurs before overt neurodegenerative disease. A total of 187 subjects (age 64-67 years) of the Metropolit Danish Male Birth Cohort participated in the study. ΔCBFVis.Act was measured using arterial spin labelling (ASL) MRI. ΔCBFVis.Act correlated positively with cognitive performance in: Global cognition (p = 0.046), paired associative memory (p = 0.025), spatial recognition (p = 0.026), planning (p = 0.016), simple processing speed (p < 0.01), and with highly significant correlations with current intelligence (p < 10-5), and more complex processing speed (p < 10-3), the latter two explaining approximately 11-13% of the variance. Reduced ΔCBFVis.Act was independent of brain atrophy. Our findings suggest that inhibited cerebrovascular response to neuronal activation is an early deficit in the ageing brain and associated with subclinical cognitive deficits. Cerebrovascular dysfunction could be an early sign of a trajectory pointing towards the development of neurodegenerative disease. Future efforts should elucidate if maintenance of a healthy cerebrovascular function can protect against the development of dementia.

U2 - 10.1007/s11357-022-00596-2

DO - 10.1007/s11357-022-00596-2

M3 - Journal article

C2 - 35648331

VL - 44

SP - 1905

EP - 1923

JO - GeroScience

JF - GeroScience

SN - 0161-9152

ER -

ID: 310071302