Reproducibility of LVEF, LV volumes, and LV mass between Rubidium-82 PET/CT scans in young healthy volunteers using two commercially available software packages

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Reproducibility of LVEF, LV volumes, and LV mass between Rubidium-82 PET/CT scans in young healthy volunteers using two commercially available software packages. / Byrne, Christina; Kjaer, Andreas; Forman, Julie Lyng; Hasbak, Philip.

I: Journal of Nuclear Cardiology, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Byrne, C, Kjaer, A, Forman, JL & Hasbak, P 2020, 'Reproducibility of LVEF, LV volumes, and LV mass between Rubidium-82 PET/CT scans in young healthy volunteers using two commercially available software packages', Journal of Nuclear Cardiology. https://doi.org/10.1007/s12350-019-01698-9

APA

Byrne, C., Kjaer, A., Forman, J. L., & Hasbak, P. (2020). Reproducibility of LVEF, LV volumes, and LV mass between Rubidium-82 PET/CT scans in young healthy volunteers using two commercially available software packages. Journal of Nuclear Cardiology. https://doi.org/10.1007/s12350-019-01698-9

Vancouver

Byrne C, Kjaer A, Forman JL, Hasbak P. Reproducibility of LVEF, LV volumes, and LV mass between Rubidium-82 PET/CT scans in young healthy volunteers using two commercially available software packages. Journal of Nuclear Cardiology. 2020. https://doi.org/10.1007/s12350-019-01698-9

Author

Byrne, Christina ; Kjaer, Andreas ; Forman, Julie Lyng ; Hasbak, Philip. / Reproducibility of LVEF, LV volumes, and LV mass between Rubidium-82 PET/CT scans in young healthy volunteers using two commercially available software packages. I: Journal of Nuclear Cardiology. 2020.

Bibtex

@article{50b3f03a43dd4c52b073af965480bcaf,
title = "Reproducibility of LVEF, LV volumes, and LV mass between Rubidium-82 PET/CT scans in young healthy volunteers using two commercially available software packages",
abstract = "BACKGROUND: Global functional parameters are available from electrocardiographic gated Rubidium-82 positron emission tomography/computed tomography (82Rb-PET/CT). However, the reproducibility of these data is not clarified. We aimed to investigate reproducibility of left ventricular ejection fraction (LVEF), endsystolic volume (ESV), enddiastolic volume (EDV), and left ventricular (LV) mass between two scans and between two commercially available software packages.METHODS AND RESULTS: Forty healthy young volunteers underwent two 82Rb-PET/CT rest and adenosine stress scans obtaining global functional parameters. Corridor4DM (4DM) and Quantitative Gated SPECT (QGS) were used for analyses. Mean (± SD) age was 24 ± 4 years and 50{\%} were men. High reproducibility of all parameters was found between scans and this was true for both software packages. LVEF at rest with 4DM: mean difference (95{\%} CI) - 1.1 (- 3.0 to 0.8), P = .25, limits of agreement: - 12.8 to 10.6. Significant differences were found between software packages on all functional parameters (P < .0001).CONCLUSION: High reproducibility was found between scans when measuring LVEF, ESV, EDV, and LV mass from 82Rb-PET/CT. However, concordance between parameter measures was poor when comparing the two software packages. Thus, global functional parameter measures are reliable, but the same software package should be used within a study and when comparing absolute values.",
author = "Christina Byrne and Andreas Kjaer and Forman, {Julie Lyng} and Philip Hasbak",
year = "2020",
doi = "10.1007/s12350-019-01698-9",
language = "English",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Reproducibility of LVEF, LV volumes, and LV mass between Rubidium-82 PET/CT scans in young healthy volunteers using two commercially available software packages

AU - Byrne, Christina

AU - Kjaer, Andreas

AU - Forman, Julie Lyng

AU - Hasbak, Philip

PY - 2020

Y1 - 2020

N2 - BACKGROUND: Global functional parameters are available from electrocardiographic gated Rubidium-82 positron emission tomography/computed tomography (82Rb-PET/CT). However, the reproducibility of these data is not clarified. We aimed to investigate reproducibility of left ventricular ejection fraction (LVEF), endsystolic volume (ESV), enddiastolic volume (EDV), and left ventricular (LV) mass between two scans and between two commercially available software packages.METHODS AND RESULTS: Forty healthy young volunteers underwent two 82Rb-PET/CT rest and adenosine stress scans obtaining global functional parameters. Corridor4DM (4DM) and Quantitative Gated SPECT (QGS) were used for analyses. Mean (± SD) age was 24 ± 4 years and 50% were men. High reproducibility of all parameters was found between scans and this was true for both software packages. LVEF at rest with 4DM: mean difference (95% CI) - 1.1 (- 3.0 to 0.8), P = .25, limits of agreement: - 12.8 to 10.6. Significant differences were found between software packages on all functional parameters (P < .0001).CONCLUSION: High reproducibility was found between scans when measuring LVEF, ESV, EDV, and LV mass from 82Rb-PET/CT. However, concordance between parameter measures was poor when comparing the two software packages. Thus, global functional parameter measures are reliable, but the same software package should be used within a study and when comparing absolute values.

AB - BACKGROUND: Global functional parameters are available from electrocardiographic gated Rubidium-82 positron emission tomography/computed tomography (82Rb-PET/CT). However, the reproducibility of these data is not clarified. We aimed to investigate reproducibility of left ventricular ejection fraction (LVEF), endsystolic volume (ESV), enddiastolic volume (EDV), and left ventricular (LV) mass between two scans and between two commercially available software packages.METHODS AND RESULTS: Forty healthy young volunteers underwent two 82Rb-PET/CT rest and adenosine stress scans obtaining global functional parameters. Corridor4DM (4DM) and Quantitative Gated SPECT (QGS) were used for analyses. Mean (± SD) age was 24 ± 4 years and 50% were men. High reproducibility of all parameters was found between scans and this was true for both software packages. LVEF at rest with 4DM: mean difference (95% CI) - 1.1 (- 3.0 to 0.8), P = .25, limits of agreement: - 12.8 to 10.6. Significant differences were found between software packages on all functional parameters (P < .0001).CONCLUSION: High reproducibility was found between scans when measuring LVEF, ESV, EDV, and LV mass from 82Rb-PET/CT. However, concordance between parameter measures was poor when comparing the two software packages. Thus, global functional parameter measures are reliable, but the same software package should be used within a study and when comparing absolute values.

U2 - 10.1007/s12350-019-01698-9

DO - 10.1007/s12350-019-01698-9

M3 - Journal article

C2 - 30919271

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

ER -

ID: 217613054