Pulmonary function of healthy Korean children from 3 independent birth cohorts: validation of the Global Lung function Initiative (GLI) 2012 equation
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Pulmonary function of healthy Korean children from 3 independent birth cohorts : validation of the Global Lung function Initiative (GLI) 2012 equation. / Park, Ji Soo; Suh, Dong In; Choi, Yun Jung; Ahn, Kangmo; Kim, Kyung Won; Shin, Youn Ho; Lee, So-Yeon; Cho, Hyun-Ju; Lee, Eun; Jang, Gwang Cheon; Kwon, Ji-Won; Sun, Yong Han; Woo, Sung-Il; Youn, You-Sook; Park, Kang Seo; Kook, Myung-Hee; Cho, Hwa Jin; Chung, Hai Lee; Kim, Ja Hyung; Kim, Hyung Young; Jung, Jin A; Woo, Hyang-Ok; Choi, Yoon Kyung; Lee, Jeong Rim; Lee, Young Ah; Shin, Choong Ho; Kim, Boong Nyun; Kim, Johanna Inhyang; Lee, Kyung-Shin; Lim, Youn Hee; Hong, Yun-Chul; Hong, Soo-Jong.
I: Pediatric Pulmonology, Bind 56, Nr. 10, 2021, s. 3310-3320.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Pulmonary function of healthy Korean children from 3 independent birth cohorts
T2 - validation of the Global Lung function Initiative (GLI) 2012 equation
AU - Park, Ji Soo
AU - Suh, Dong In
AU - Choi, Yun Jung
AU - Ahn, Kangmo
AU - Kim, Kyung Won
AU - Shin, Youn Ho
AU - Lee, So-Yeon
AU - Cho, Hyun-Ju
AU - Lee, Eun
AU - Jang, Gwang Cheon
AU - Kwon, Ji-Won
AU - Sun, Yong Han
AU - Woo, Sung-Il
AU - Youn, You-Sook
AU - Park, Kang Seo
AU - Kook, Myung-Hee
AU - Cho, Hwa Jin
AU - Chung, Hai Lee
AU - Kim, Ja Hyung
AU - Kim, Hyung Young
AU - Jung, Jin A
AU - Woo, Hyang-Ok
AU - Choi, Yoon Kyung
AU - Lee, Jeong Rim
AU - Lee, Young Ah
AU - Shin, Choong Ho
AU - Kim, Boong Nyun
AU - Kim, Johanna Inhyang
AU - Lee, Kyung-Shin
AU - Lim, Youn Hee
AU - Hong, Yun-Chul
AU - Hong, Soo-Jong
PY - 2021
Y1 - 2021
N2 - Background and objective Global Lung Function Initiative (GLI) 2012 equations were developed to resolve the age-related disparity in interpreting spirometry results. Local validation of the equation is needed, especially in Northeast Asian children. This study evaluated the GLI equation in Korean children. Methods Spirometry indices (FEV1, FVC, FEV1/FVC and FEF25-75 and clinical information were gathered from three population-based birth cohorts. Predicted GLI reference values and z-scores of spirometry results were calculated for 1239 healthy children. The mean, standard deviation of z-scores were compared to the expected 0 and 1. Probabilities of falling below the lower limit of normal [LLN] (z-score: -1.64) were compared to the expected value 5scores were assessed according to low (2) BMI z-score groups. Results Mean z-scores significantly differed from 0 for FEV1/FVC in males (mean [95: 0.18 [0.08, 0.27]) and FEV1 and FVC in females (-0.23 [-0.31, -0.15] and -0.26 [-0.36, -0.16], respectively). The standard deviation was larger than 1 for all variables in males and FVC and FEV1/FVC in females. The probability of falling below the LLN was significantly larger than 5 (12.139.64, 14.77]), FVC (15.8613.06, 18.81]), and FEF25–757.315.29, 9.49]) in males and FVC (11.919.40, 14.60]) in females. FEV1 and FVC z-scores increased across low to high BMI groups, and FEV1/FVC decreased from low to high BMI groups. Conclusion GLI equations marginally differ from real-world values, which should be considered by pulmonologists in practice or research.
AB - Background and objective Global Lung Function Initiative (GLI) 2012 equations were developed to resolve the age-related disparity in interpreting spirometry results. Local validation of the equation is needed, especially in Northeast Asian children. This study evaluated the GLI equation in Korean children. Methods Spirometry indices (FEV1, FVC, FEV1/FVC and FEF25-75 and clinical information were gathered from three population-based birth cohorts. Predicted GLI reference values and z-scores of spirometry results were calculated for 1239 healthy children. The mean, standard deviation of z-scores were compared to the expected 0 and 1. Probabilities of falling below the lower limit of normal [LLN] (z-score: -1.64) were compared to the expected value 5scores were assessed according to low (2) BMI z-score groups. Results Mean z-scores significantly differed from 0 for FEV1/FVC in males (mean [95: 0.18 [0.08, 0.27]) and FEV1 and FVC in females (-0.23 [-0.31, -0.15] and -0.26 [-0.36, -0.16], respectively). The standard deviation was larger than 1 for all variables in males and FVC and FEV1/FVC in females. The probability of falling below the LLN was significantly larger than 5 (12.139.64, 14.77]), FVC (15.8613.06, 18.81]), and FEF25–757.315.29, 9.49]) in males and FVC (11.919.40, 14.60]) in females. FEV1 and FVC z-scores increased across low to high BMI groups, and FEV1/FVC decreased from low to high BMI groups. Conclusion GLI equations marginally differ from real-world values, which should be considered by pulmonologists in practice or research.
KW - Asian
KW - Children
KW - Global Lung Function Initiative
KW - Reference equation
KW - Spirometry
U2 - 10.1002/ppul.25622
DO - 10.1002/ppul.25622
M3 - Journal article
C2 - 34375041
VL - 56
SP - 3310
EP - 3320
JO - Pediatric pulmonology. Supplement
JF - Pediatric pulmonology. Supplement
SN - 1054-187X
IS - 10
ER -
ID: 276230675