Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes: A systematic review and meta-analysis

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Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes : A systematic review and meta-analysis. / Lee, Dong-Wook; Kim, Min-Seok; Lim, Youn-Hee; Lee, Nami; Hong, Yun-Chul.

I: Environmental Research, Bind 167, 2018, s. 558-566.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Lee, D-W, Kim, M-S, Lim, Y-H, Lee, N & Hong, Y-C 2018, 'Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes: A systematic review and meta-analysis', Environmental Research, bind 167, s. 558-566. https://doi.org/10.1016/j.envres.2018.08.023

APA

Lee, D-W., Kim, M-S., Lim, Y-H., Lee, N., & Hong, Y-C. (2018). Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes: A systematic review and meta-analysis. Environmental Research, 167, 558-566. https://doi.org/10.1016/j.envres.2018.08.023

Vancouver

Lee D-W, Kim M-S, Lim Y-H, Lee N, Hong Y-C. Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes: A systematic review and meta-analysis. Environmental Research. 2018;167:558-566. https://doi.org/10.1016/j.envres.2018.08.023

Author

Lee, Dong-Wook ; Kim, Min-Seok ; Lim, Youn-Hee ; Lee, Nami ; Hong, Yun-Chul. / Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes : A systematic review and meta-analysis. I: Environmental Research. 2018 ; Bind 167. s. 558-566.

Bibtex

@article{f9c2423d749342d49ac8daf1fb3d1a9a,
title = "Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes: A systematic review and meta-analysis",
abstract = "BACKGROUND: Di-(2-ethylhexyl) phthalate (DEHP), the most widely used phthalate, has recently been associated with neurodevelopmental disturbances in children. However, the risk is yet to be quantified. Therefore, a systematic review and meta-analysis focusing on the association between exposure to DEHP and neurodevelopmental outcomes is necessary, with particular attention to study design (longitudinal vs. cross-sectional).METHODS: We performed a comprehensive literature search for associations between exposure to DEHP and neurodevelopmental outcomes. Among 106 published studies found in public databases, eight longitudinal studies and two cross-sectional studies were included in the meta-analysis.RESULTS: We observed a statistically significant association between the concentrations of DEHP metabolites and the neurodevelopment outcomes of children among cross-sectional results, and found significant association between DEHP exposure measured in prenatal period and the psychomotor development outcomes measured later in childhood.CONCLUSIONS: To our knowledge, this is the first meta-analysis of studies investigating the association between DEHP exposure and neurodevelopment in children. A need exists for more researches and a precautionary policy for potential health hazard of DEHP, the most commonly used phthalate, to promote healthier neurodevelopment in children.",
keywords = "Child, Child Development, Cross-Sectional Studies, Diethylhexyl Phthalate/adverse effects, Female, Humans, Longitudinal Studies, Pregnancy, Prenatal Exposure Delayed Effects/epidemiology, Psychomotor Disorders/epidemiology",
author = "Dong-Wook Lee and Min-Seok Kim and Youn-Hee Lim and Nami Lee and Yun-Chul Hong",
note = "Copyright {\textcopyright} 2018 Elsevier Inc. All rights reserved.",
year = "2018",
doi = "10.1016/j.envres.2018.08.023",
language = "English",
volume = "167",
pages = "558--566",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes

T2 - A systematic review and meta-analysis

AU - Lee, Dong-Wook

AU - Kim, Min-Seok

AU - Lim, Youn-Hee

AU - Lee, Nami

AU - Hong, Yun-Chul

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Di-(2-ethylhexyl) phthalate (DEHP), the most widely used phthalate, has recently been associated with neurodevelopmental disturbances in children. However, the risk is yet to be quantified. Therefore, a systematic review and meta-analysis focusing on the association between exposure to DEHP and neurodevelopmental outcomes is necessary, with particular attention to study design (longitudinal vs. cross-sectional).METHODS: We performed a comprehensive literature search for associations between exposure to DEHP and neurodevelopmental outcomes. Among 106 published studies found in public databases, eight longitudinal studies and two cross-sectional studies were included in the meta-analysis.RESULTS: We observed a statistically significant association between the concentrations of DEHP metabolites and the neurodevelopment outcomes of children among cross-sectional results, and found significant association between DEHP exposure measured in prenatal period and the psychomotor development outcomes measured later in childhood.CONCLUSIONS: To our knowledge, this is the first meta-analysis of studies investigating the association between DEHP exposure and neurodevelopment in children. A need exists for more researches and a precautionary policy for potential health hazard of DEHP, the most commonly used phthalate, to promote healthier neurodevelopment in children.

AB - BACKGROUND: Di-(2-ethylhexyl) phthalate (DEHP), the most widely used phthalate, has recently been associated with neurodevelopmental disturbances in children. However, the risk is yet to be quantified. Therefore, a systematic review and meta-analysis focusing on the association between exposure to DEHP and neurodevelopmental outcomes is necessary, with particular attention to study design (longitudinal vs. cross-sectional).METHODS: We performed a comprehensive literature search for associations between exposure to DEHP and neurodevelopmental outcomes. Among 106 published studies found in public databases, eight longitudinal studies and two cross-sectional studies were included in the meta-analysis.RESULTS: We observed a statistically significant association between the concentrations of DEHP metabolites and the neurodevelopment outcomes of children among cross-sectional results, and found significant association between DEHP exposure measured in prenatal period and the psychomotor development outcomes measured later in childhood.CONCLUSIONS: To our knowledge, this is the first meta-analysis of studies investigating the association between DEHP exposure and neurodevelopment in children. A need exists for more researches and a precautionary policy for potential health hazard of DEHP, the most commonly used phthalate, to promote healthier neurodevelopment in children.

KW - Child

KW - Child Development

KW - Cross-Sectional Studies

KW - Diethylhexyl Phthalate/adverse effects

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects/epidemiology

KW - Psychomotor Disorders/epidemiology

U2 - 10.1016/j.envres.2018.08.023

DO - 10.1016/j.envres.2018.08.023

M3 - Journal article

C2 - 30145432

VL - 167

SP - 558

EP - 566

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -

ID: 230066234