Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

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Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women. / Boas, M.; Forman, Julie Lyng; Juul, A.; Feldt-Rasmussen, U.; Skakkebaek, N.E.; Hilsted, L.; Chellakooty, M.; Larsen, T.; Larsen, J.F.; Petersen, Jørgen Holm; Main, K.M.

I: European Journal of Endocrinology, Bind 161, Nr. 6, 2009, s. 903-910.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Boas, M, Forman, JL, Juul, A, Feldt-Rasmussen, U, Skakkebaek, NE, Hilsted, L, Chellakooty, M, Larsen, T, Larsen, JF, Petersen, JH & Main, KM 2009, 'Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women', European Journal of Endocrinology, bind 161, nr. 6, s. 903-910. https://doi.org/10.1530/EJE-09-0579

APA

Boas, M., Forman, J. L., Juul, A., Feldt-Rasmussen, U., Skakkebaek, N. E., Hilsted, L., ... Main, K. M. (2009). Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women. European Journal of Endocrinology, 161(6), 903-910. https://doi.org/10.1530/EJE-09-0579

Vancouver

Boas M, Forman JL, Juul A, Feldt-Rasmussen U, Skakkebaek NE, Hilsted L o.a. Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women. European Journal of Endocrinology. 2009;161(6):903-910. https://doi.org/10.1530/EJE-09-0579

Author

Boas, M. ; Forman, Julie Lyng ; Juul, A. ; Feldt-Rasmussen, U. ; Skakkebaek, N.E. ; Hilsted, L. ; Chellakooty, M. ; Larsen, T. ; Larsen, J.F. ; Petersen, Jørgen Holm ; Main, K.M. / Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women. I: European Journal of Endocrinology. 2009 ; Bind 161, Nr. 6. s. 903-910.

Bibtex

@article{22785370583b11df928f000ea68e967b,
title = "Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women",
abstract = "BACKGROUND: Adaptive alterations in maternal physiology cause changes in thyroid hormone levels throughout pregnancy, and precise biochemical evaluation is thus highly dependent on gestation-specific reference intervals and expected intra-individual variation. OBJECTIVE: The aim of the study was the assessment of the intra-individual variation as well as the longitudinal course of thyroid hormones during normal pregnancy and factors that influence the normal reference range for thyroid function. For this purpose, a longitudinal statistical model was applied. DESIGN: In a cohort of 132 pregnant women, serial blood samples were obtained and ultrasound scans were performed throughout pregnancy. METHODS: Serum levels of TSH, free and total thyroxine (T(4)), free and total triiodothyronine (T(3)) as well as autoantibodies against thyroid peroxidase and thyroglobulin were measured in 979 serum samples. RESULTS: Intra-individual variations of thyroid hormone concentrations were smaller than inter-individual variations (individuality index range: 0.38-0.71). Maternal height was positively associated with free T(4) (FT(4)) (b=0.003; P=0.031) and pre-pregnancy body mass index with T(3) and free T(3) (b=0.017; <0.001 and b=0.007; P<0.001). Smoking was positively associated with T(4) and FT(4), but it was modulated by gestational age. Gestation-specific reference intervals for thyroid function variables from autoantibody-negative participants are presented. CONCLUSIONS: In accordance with the data from nonpregnant adults, intra-individual variations of thyroid hormones were smaller than inter-individual variations also during pregnancy. In the evaluation of thyroid function in pregnancy, the individual longitudinal course of thyroid hormones rather than absolute values should be considered. We present a longitudinal model for the prediction of maternal thyroid function tests in pregnant women Udgivelsesdato: 2009/12",
author = "M. Boas and Forman, {Julie Lyng} and A. Juul and U. Feldt-Rasmussen and N.E. Skakkebaek and L. Hilsted and M. Chellakooty and T. Larsen and J.F. Larsen and Petersen, {J{\o}rgen Holm} and K.M. Main",
year = "2009",
doi = "10.1530/EJE-09-0579",
language = "English",
volume = "161",
pages = "903--910",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women

AU - Boas, M.

AU - Forman, Julie Lyng

AU - Juul, A.

AU - Feldt-Rasmussen, U.

AU - Skakkebaek, N.E.

AU - Hilsted, L.

AU - Chellakooty, M.

AU - Larsen, T.

AU - Larsen, J.F.

AU - Petersen, Jørgen Holm

AU - Main, K.M.

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Adaptive alterations in maternal physiology cause changes in thyroid hormone levels throughout pregnancy, and precise biochemical evaluation is thus highly dependent on gestation-specific reference intervals and expected intra-individual variation. OBJECTIVE: The aim of the study was the assessment of the intra-individual variation as well as the longitudinal course of thyroid hormones during normal pregnancy and factors that influence the normal reference range for thyroid function. For this purpose, a longitudinal statistical model was applied. DESIGN: In a cohort of 132 pregnant women, serial blood samples were obtained and ultrasound scans were performed throughout pregnancy. METHODS: Serum levels of TSH, free and total thyroxine (T(4)), free and total triiodothyronine (T(3)) as well as autoantibodies against thyroid peroxidase and thyroglobulin were measured in 979 serum samples. RESULTS: Intra-individual variations of thyroid hormone concentrations were smaller than inter-individual variations (individuality index range: 0.38-0.71). Maternal height was positively associated with free T(4) (FT(4)) (b=0.003; P=0.031) and pre-pregnancy body mass index with T(3) and free T(3) (b=0.017; <0.001 and b=0.007; P<0.001). Smoking was positively associated with T(4) and FT(4), but it was modulated by gestational age. Gestation-specific reference intervals for thyroid function variables from autoantibody-negative participants are presented. CONCLUSIONS: In accordance with the data from nonpregnant adults, intra-individual variations of thyroid hormones were smaller than inter-individual variations also during pregnancy. In the evaluation of thyroid function in pregnancy, the individual longitudinal course of thyroid hormones rather than absolute values should be considered. We present a longitudinal model for the prediction of maternal thyroid function tests in pregnant women Udgivelsesdato: 2009/12

AB - BACKGROUND: Adaptive alterations in maternal physiology cause changes in thyroid hormone levels throughout pregnancy, and precise biochemical evaluation is thus highly dependent on gestation-specific reference intervals and expected intra-individual variation. OBJECTIVE: The aim of the study was the assessment of the intra-individual variation as well as the longitudinal course of thyroid hormones during normal pregnancy and factors that influence the normal reference range for thyroid function. For this purpose, a longitudinal statistical model was applied. DESIGN: In a cohort of 132 pregnant women, serial blood samples were obtained and ultrasound scans were performed throughout pregnancy. METHODS: Serum levels of TSH, free and total thyroxine (T(4)), free and total triiodothyronine (T(3)) as well as autoantibodies against thyroid peroxidase and thyroglobulin were measured in 979 serum samples. RESULTS: Intra-individual variations of thyroid hormone concentrations were smaller than inter-individual variations (individuality index range: 0.38-0.71). Maternal height was positively associated with free T(4) (FT(4)) (b=0.003; P=0.031) and pre-pregnancy body mass index with T(3) and free T(3) (b=0.017; <0.001 and b=0.007; P<0.001). Smoking was positively associated with T(4) and FT(4), but it was modulated by gestational age. Gestation-specific reference intervals for thyroid function variables from autoantibody-negative participants are presented. CONCLUSIONS: In accordance with the data from nonpregnant adults, intra-individual variations of thyroid hormones were smaller than inter-individual variations also during pregnancy. In the evaluation of thyroid function in pregnancy, the individual longitudinal course of thyroid hormones rather than absolute values should be considered. We present a longitudinal model for the prediction of maternal thyroid function tests in pregnant women Udgivelsesdato: 2009/12

U2 - 10.1530/EJE-09-0579

DO - 10.1530/EJE-09-0579

M3 - Journal article

C2 - 19773370

VL - 161

SP - 903

EP - 910

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 6

ER -

ID: 19572692