Mortality in women treated with assisted reproductive technology treatment: addressing the healthy patient effect
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Mortality in women treated with assisted reproductive technology treatment : addressing the healthy patient effect. / Vassard, Ditte; Schmidt, Lone; Pinborg, Anja; Lindved Petersen, Gitte; Forman, Julie Lyng; Hageman, Ida; Glazer, Clara Helene; Kamper-Jørgensen, Mads.
I: American Journal of Epidemiology, Bind 187, Nr. 9, 2018, s. 1889-1895.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mortality in women treated with assisted reproductive technology treatment
T2 - addressing the healthy patient effect
AU - Vassard, Ditte
AU - Schmidt, Lone
AU - Pinborg, Anja
AU - Lindved Petersen, Gitte
AU - Forman, Julie Lyng
AU - Hageman, Ida
AU - Glazer, Clara Helene
AU - Kamper-Jørgensen, Mads
PY - 2018
Y1 - 2018
N2 - Previous studies have reported reduced mortality among women undergoing assisted reproductive technology (ART) treatment, possibly related to selection of healthy women into ART treatment. The aim of this study was to explore the impact of relevant selection factors on the association between ART treatment and mortality and explore effect modification by parity. Women treated with ART in fertility clinics in Denmark during 1994-2009 (n = 42,897) were age-matched with untreated women from the background population (n = 204,514) and followed until ultimo 2010. With adjustment for relevant confounders, the risk of death was lower among ART-treated women immediately after ART treatment (HR = 0.68, 95% CI: 0.63, 0.74), but there was no apparent difference after 10 years (HR = 0.92, 95% CI: 0.79, 1.07). Having children prior to ART treatment was associated with a markedly reduced mortality (HR = 0.45, 95% CI: 0.38, 0.53), possibly due to better health among fertile women. While the frequency of previous medical and psychiatric diagnoses among ART-treated and untreated women was similar, differences in disease severity could explain the reduced mortality among ART-treated women, as poor prognosis would make ART treatment initiation unlikely. The survival advantage among ART-treated women is likely a selection rather than a biological phenomenon.
AB - Previous studies have reported reduced mortality among women undergoing assisted reproductive technology (ART) treatment, possibly related to selection of healthy women into ART treatment. The aim of this study was to explore the impact of relevant selection factors on the association between ART treatment and mortality and explore effect modification by parity. Women treated with ART in fertility clinics in Denmark during 1994-2009 (n = 42,897) were age-matched with untreated women from the background population (n = 204,514) and followed until ultimo 2010. With adjustment for relevant confounders, the risk of death was lower among ART-treated women immediately after ART treatment (HR = 0.68, 95% CI: 0.63, 0.74), but there was no apparent difference after 10 years (HR = 0.92, 95% CI: 0.79, 1.07). Having children prior to ART treatment was associated with a markedly reduced mortality (HR = 0.45, 95% CI: 0.38, 0.53), possibly due to better health among fertile women. While the frequency of previous medical and psychiatric diagnoses among ART-treated and untreated women was similar, differences in disease severity could explain the reduced mortality among ART-treated women, as poor prognosis would make ART treatment initiation unlikely. The survival advantage among ART-treated women is likely a selection rather than a biological phenomenon.
U2 - 10.1093/aje/kwy085
DO - 10.1093/aje/kwy085
M3 - Journal article
C2 - 29846493
VL - 187
SP - 1889
EP - 1895
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 9
ER -
ID: 199757484