Maternal Urinary Bisphenol A Concentration During Midterm Pregnancy and Children's Blood Pressure at Age 4
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Maternal Urinary Bisphenol A Concentration During Midterm Pregnancy and Children's Blood Pressure at Age 4. / Bae, Sanghyuk; Lim, Youn-Hee; Lee, Young Ah; Shin, Choong Ho; Oh, Se-Young; Hong, Yun-Chul.
I: Hypertension, Bind 69, Nr. 2, 2017, s. 367-374.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Maternal Urinary Bisphenol A Concentration During Midterm Pregnancy and Children's Blood Pressure at Age 4
AU - Bae, Sanghyuk
AU - Lim, Youn-Hee
AU - Lee, Young Ah
AU - Shin, Choong Ho
AU - Oh, Se-Young
AU - Hong, Yun-Chul
N1 - © 2016 American Heart Association, Inc.
PY - 2017
Y1 - 2017
N2 - Bisphenol A (BPA) has been reported to be associated with adverse health effects, including high blood pressure (BP). BPA is also suspected to cross placenta in pregnancy and might affect children's health. The present study was aimed to evaluate the effect of prenatal exposure to BPA on the BP of the child at the age of 4. We followed up 645 children at the age of 4 who were born from women who participated midterm during their pregnancy in a birth cohort study from August 2008 to July 2011. Because BPA and BP showed nonlinear association, we constructed a piecewise regression model to examine the association between urinary BPA concentration of mother at around 20 weeks of gestation and BP of the child at age 4 and to determine threshold level of BPA for the association. Diastolic BP of the children was positively associated with maternal urinary concentration of BPA above the threshold level measured at around 20 weeks of gestation. For 1 log unit increment of prenatal urinary BPA concentration, diastolic BP was increased by 7.9 mm Hg (SE=2.072; P=0.0001) after adjusting potential confounders. Pulse pressure was decreased by -8.0 mm Hg (SE=2.528; P=0.0015). However, systolic BP was not significantly associated with prenatal BPA concentration. The present study suggests that exposure to BPA during pregnancy is associated with higher diastolic BP of the children above a certain threshold (4.5 μg/g creatinine).
AB - Bisphenol A (BPA) has been reported to be associated with adverse health effects, including high blood pressure (BP). BPA is also suspected to cross placenta in pregnancy and might affect children's health. The present study was aimed to evaluate the effect of prenatal exposure to BPA on the BP of the child at the age of 4. We followed up 645 children at the age of 4 who were born from women who participated midterm during their pregnancy in a birth cohort study from August 2008 to July 2011. Because BPA and BP showed nonlinear association, we constructed a piecewise regression model to examine the association between urinary BPA concentration of mother at around 20 weeks of gestation and BP of the child at age 4 and to determine threshold level of BPA for the association. Diastolic BP of the children was positively associated with maternal urinary concentration of BPA above the threshold level measured at around 20 weeks of gestation. For 1 log unit increment of prenatal urinary BPA concentration, diastolic BP was increased by 7.9 mm Hg (SE=2.072; P=0.0001) after adjusting potential confounders. Pulse pressure was decreased by -8.0 mm Hg (SE=2.528; P=0.0015). However, systolic BP was not significantly associated with prenatal BPA concentration. The present study suggests that exposure to BPA during pregnancy is associated with higher diastolic BP of the children above a certain threshold (4.5 μg/g creatinine).
KW - Adult
KW - Air Pollutants, Occupational/urine
KW - Benzhydryl Compounds/urine
KW - Blood Pressure/physiology
KW - Blood Pressure Determination
KW - Child, Preschool
KW - Diastole
KW - Female
KW - Follow-Up Studies
KW - Gestational Age
KW - Humans
KW - Incidence
KW - Male
KW - Phenols/urine
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects/epidemiology
KW - Republic of Korea/epidemiology
KW - Retrospective Studies
KW - Time Factors
U2 - 10.1161/HYPERTENSIONAHA.116.08281
DO - 10.1161/HYPERTENSIONAHA.116.08281
M3 - Journal article
C2 - 27920131
VL - 69
SP - 367
EP - 374
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 2
ER -
ID: 230069357