Male factor infertility and risk of multiple sclerosis: A register-based cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Male factor infertility and risk of multiple sclerosis : A register-based cohort study. / Glazer, Clara Helene; Tøttenborg, Sandra Søgaard; Giwercman, Aleksander; Bräuner, Elvira Vaclavik; Eisenberg, Michael L; Vassard, Ditte; Magyari, Melinda; Pinborg, Anja; Schmidt, Lone; Bonde, Jens Peter.

I: Multiple Sclerosis, Bind 24, Nr. 14, 01.12.2018, s. 1835-1842.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Glazer, CH, Tøttenborg, SS, Giwercman, A, Bräuner, EV, Eisenberg, ML, Vassard, D, Magyari, M, Pinborg, A, Schmidt, L & Bonde, JP 2018, 'Male factor infertility and risk of multiple sclerosis: A register-based cohort study', Multiple Sclerosis, bind 24, nr. 14, s. 1835-1842. https://doi.org/10.1177/1352458517734069

APA

Glazer, C. H., Tøttenborg, S. S., Giwercman, A., Bräuner, E. V., Eisenberg, M. L., Vassard, D., ... Bonde, J. P. (2018). Male factor infertility and risk of multiple sclerosis: A register-based cohort study. Multiple Sclerosis, 24(14), 1835-1842. https://doi.org/10.1177/1352458517734069

Vancouver

Glazer CH, Tøttenborg SS, Giwercman A, Bräuner EV, Eisenberg ML, Vassard D o.a. Male factor infertility and risk of multiple sclerosis: A register-based cohort study. Multiple Sclerosis. 2018 dec 1;24(14):1835-1842. https://doi.org/10.1177/1352458517734069

Author

Glazer, Clara Helene ; Tøttenborg, Sandra Søgaard ; Giwercman, Aleksander ; Bräuner, Elvira Vaclavik ; Eisenberg, Michael L ; Vassard, Ditte ; Magyari, Melinda ; Pinborg, Anja ; Schmidt, Lone ; Bonde, Jens Peter. / Male factor infertility and risk of multiple sclerosis : A register-based cohort study. I: Multiple Sclerosis. 2018 ; Bind 24, Nr. 14. s. 1835-1842.

Bibtex

@article{1dcf5e23aa8242609f9fbb962696d6f4,
title = "Male factor infertility and risk of multiple sclerosis: A register-based cohort study",
abstract = "BACKGROUND: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS.OBJECTIVE: To study the association between male factor infertility and prevalent as well as incident MS.METHOD: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015.RESULTS: With a median age of 34 years at baseline, 24,011 men were diagnosed with male factor infertility and 27,052 did not have male factor infertility and made up the reference group. Men diagnosed with male factor infertility had a higher risk of prevalent (odds ratio (OR) = 1.61, 95{\%} confidence interval (95{\%} CI) 1.04-2.51) and incident MS (hazard ratio (HR) = 1.28, 95{\%} CI 0.76-2.17) when compared to the reference group.CONCLUSION: This nationwide cohort study has shown, for the first time, an association between male infertility and MS which may be due to underlying common etiologies such as hypogonadism, shared genetics, or a joint autoimmune component.",
keywords = "Journal Article, epidemiology, gender, Male infertility, multiple sclerosis, fertility, semen quality",
author = "Glazer, {Clara Helene} and T{\o}ttenborg, {Sandra S{\o}gaard} and Aleksander Giwercman and Br{\"a}uner, {Elvira Vaclavik} and Eisenberg, {Michael L} and Ditte Vassard and Melinda Magyari and Anja Pinborg and Lone Schmidt and Bonde, {Jens Peter}",
year = "2018",
month = "12",
day = "1",
doi = "10.1177/1352458517734069",
language = "English",
volume = "24",
pages = "1835--1842",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "SAGE Publications",
number = "14",

}

RIS

TY - JOUR

T1 - Male factor infertility and risk of multiple sclerosis

T2 - A register-based cohort study

AU - Glazer, Clara Helene

AU - Tøttenborg, Sandra Søgaard

AU - Giwercman, Aleksander

AU - Bräuner, Elvira Vaclavik

AU - Eisenberg, Michael L

AU - Vassard, Ditte

AU - Magyari, Melinda

AU - Pinborg, Anja

AU - Schmidt, Lone

AU - Bonde, Jens Peter

PY - 2018/12/1

Y1 - 2018/12/1

N2 - BACKGROUND: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS.OBJECTIVE: To study the association between male factor infertility and prevalent as well as incident MS.METHOD: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015.RESULTS: With a median age of 34 years at baseline, 24,011 men were diagnosed with male factor infertility and 27,052 did not have male factor infertility and made up the reference group. Men diagnosed with male factor infertility had a higher risk of prevalent (odds ratio (OR) = 1.61, 95% confidence interval (95% CI) 1.04-2.51) and incident MS (hazard ratio (HR) = 1.28, 95% CI 0.76-2.17) when compared to the reference group.CONCLUSION: This nationwide cohort study has shown, for the first time, an association between male infertility and MS which may be due to underlying common etiologies such as hypogonadism, shared genetics, or a joint autoimmune component.

AB - BACKGROUND: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS.OBJECTIVE: To study the association between male factor infertility and prevalent as well as incident MS.METHOD: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015.RESULTS: With a median age of 34 years at baseline, 24,011 men were diagnosed with male factor infertility and 27,052 did not have male factor infertility and made up the reference group. Men diagnosed with male factor infertility had a higher risk of prevalent (odds ratio (OR) = 1.61, 95% confidence interval (95% CI) 1.04-2.51) and incident MS (hazard ratio (HR) = 1.28, 95% CI 0.76-2.17) when compared to the reference group.CONCLUSION: This nationwide cohort study has shown, for the first time, an association between male infertility and MS which may be due to underlying common etiologies such as hypogonadism, shared genetics, or a joint autoimmune component.

KW - Journal Article

KW - epidemiology

KW - gender

KW - Male infertility

KW - multiple sclerosis

KW - fertility

KW - semen quality

U2 - 10.1177/1352458517734069

DO - 10.1177/1352458517734069

M3 - Journal article

C2 - 29027840

VL - 24

SP - 1835

EP - 1842

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 14

ER -

ID: 184604137