Magnetic Resonance Imaging: A New Tool to Optimize the Prediction of Fetal Anemia?

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Magnetic Resonance Imaging : A New Tool to Optimize the Prediction of Fetal Anemia? / Jørgensen, Ditte S.; Vejlstrup, Niels; Rode, Line; Ekelund, Charlotte K; Macgowan, Christopher K; Jensen, Lisa N; Nørgaard, Lone Nikoline; Portnoy, Sharon; Seed, Mike; Sundberg, Karin; Søgaard, Kirsten; Forman, Julie Lyng; Tabor, Ann.

I: Fetal Diagnosis and Therapy, Bind 46, Nr. 4, 2019, s. 257-265.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Jørgensen, DS, Vejlstrup, N, Rode, L, Ekelund, CK, Macgowan, CK, Jensen, LN, Nørgaard, LN, Portnoy, S, Seed, M, Sundberg, K, Søgaard, K, Forman, JL & Tabor, A 2019, 'Magnetic Resonance Imaging: A New Tool to Optimize the Prediction of Fetal Anemia?', Fetal Diagnosis and Therapy, bind 46, nr. 4, s. 257-265. https://doi.org/10.1159/000494615

APA

Jørgensen, D. S., Vejlstrup, N., Rode, L., Ekelund, C. K., Macgowan, C. K., Jensen, L. N., Nørgaard, L. N., Portnoy, S., Seed, M., Sundberg, K., Søgaard, K., Forman, J. L., & Tabor, A. (2019). Magnetic Resonance Imaging: A New Tool to Optimize the Prediction of Fetal Anemia? Fetal Diagnosis and Therapy, 46(4), 257-265. https://doi.org/10.1159/000494615

Vancouver

Jørgensen DS, Vejlstrup N, Rode L, Ekelund CK, Macgowan CK, Jensen LN o.a. Magnetic Resonance Imaging: A New Tool to Optimize the Prediction of Fetal Anemia? Fetal Diagnosis and Therapy. 2019;46(4):257-265. https://doi.org/10.1159/000494615

Author

Jørgensen, Ditte S. ; Vejlstrup, Niels ; Rode, Line ; Ekelund, Charlotte K ; Macgowan, Christopher K ; Jensen, Lisa N ; Nørgaard, Lone Nikoline ; Portnoy, Sharon ; Seed, Mike ; Sundberg, Karin ; Søgaard, Kirsten ; Forman, Julie Lyng ; Tabor, Ann. / Magnetic Resonance Imaging : A New Tool to Optimize the Prediction of Fetal Anemia?. I: Fetal Diagnosis and Therapy. 2019 ; Bind 46, Nr. 4. s. 257-265.

Bibtex

@article{9f4d51850b21459986a926b205cab8a2,
title = "Magnetic Resonance Imaging: A New Tool to Optimize the Prediction of Fetal Anemia?",
abstract = "INTRODUCTION: The false-positive rate in the prediction of fetal anemia is 10-15%. We investigated if a new, noninvasive MRI method used as a supplement to ultrasound could improve the prediction.METHODS: Fetuses suspected of anemia and controls were scanned in a 1.5-tesla MRI scanner 1-4 times during pregnancy. Cases were scanned before and after intrauterine blood transfusion with a T1-mapping MRI sequence in a cross-section of the umbilical vein.RESULTS: Inclusion of 8 cases and 11 controls resulted in 10 case scans (2 cases were included twice) and 33 control scans. In controls, the T1 relaxation time was 1,005-1,391 ms; in cases with severe anemia, 1,505-1,595 ms, moderate anemia 1,503-1,525 ms, and no/mild anemia 1,245-1,410 ms. After blood transfusions, values dropped to 1,123-1,288 ms. The mean value in moderate and severe anemic cases was 275 ms higher than in controls (95% CI 210-341 ms, p < 0.0001), and after blood transfusion it was comparable to controls (3 ms, 95% CI -62 to 68 ms, p = 0.934). A 1,450-ms cut-off would have identified all cases in need of blood transfusion with no false-positive cases.CONCLUSIONS: Our findings indicate a potential for this new MRI method to improve the prediction of fetal anemia as a supplement to ultrasound.",
author = "J{\o}rgensen, {Ditte S.} and Niels Vejlstrup and Line Rode and Ekelund, {Charlotte K} and Macgowan, {Christopher K} and Jensen, {Lisa N} and N{\o}rgaard, {Lone Nikoline} and Sharon Portnoy and Mike Seed and Karin Sundberg and Kirsten S{\o}gaard and Forman, {Julie Lyng} and Ann Tabor",
note = "{\textcopyright} 2019 S. Karger AG, Basel.",
year = "2019",
doi = "10.1159/000494615",
language = "English",
volume = "46",
pages = "257--265",
journal = "Fetal Diagnosis and Therapy",
issn = "1015-3837",
publisher = "S Karger AG",
number = "4",

}

RIS

TY - JOUR

T1 - Magnetic Resonance Imaging

T2 - A New Tool to Optimize the Prediction of Fetal Anemia?

AU - Jørgensen, Ditte S.

AU - Vejlstrup, Niels

AU - Rode, Line

AU - Ekelund, Charlotte K

AU - Macgowan, Christopher K

AU - Jensen, Lisa N

AU - Nørgaard, Lone Nikoline

AU - Portnoy, Sharon

AU - Seed, Mike

AU - Sundberg, Karin

AU - Søgaard, Kirsten

AU - Forman, Julie Lyng

AU - Tabor, Ann

N1 - © 2019 S. Karger AG, Basel.

PY - 2019

Y1 - 2019

N2 - INTRODUCTION: The false-positive rate in the prediction of fetal anemia is 10-15%. We investigated if a new, noninvasive MRI method used as a supplement to ultrasound could improve the prediction.METHODS: Fetuses suspected of anemia and controls were scanned in a 1.5-tesla MRI scanner 1-4 times during pregnancy. Cases were scanned before and after intrauterine blood transfusion with a T1-mapping MRI sequence in a cross-section of the umbilical vein.RESULTS: Inclusion of 8 cases and 11 controls resulted in 10 case scans (2 cases were included twice) and 33 control scans. In controls, the T1 relaxation time was 1,005-1,391 ms; in cases with severe anemia, 1,505-1,595 ms, moderate anemia 1,503-1,525 ms, and no/mild anemia 1,245-1,410 ms. After blood transfusions, values dropped to 1,123-1,288 ms. The mean value in moderate and severe anemic cases was 275 ms higher than in controls (95% CI 210-341 ms, p < 0.0001), and after blood transfusion it was comparable to controls (3 ms, 95% CI -62 to 68 ms, p = 0.934). A 1,450-ms cut-off would have identified all cases in need of blood transfusion with no false-positive cases.CONCLUSIONS: Our findings indicate a potential for this new MRI method to improve the prediction of fetal anemia as a supplement to ultrasound.

AB - INTRODUCTION: The false-positive rate in the prediction of fetal anemia is 10-15%. We investigated if a new, noninvasive MRI method used as a supplement to ultrasound could improve the prediction.METHODS: Fetuses suspected of anemia and controls were scanned in a 1.5-tesla MRI scanner 1-4 times during pregnancy. Cases were scanned before and after intrauterine blood transfusion with a T1-mapping MRI sequence in a cross-section of the umbilical vein.RESULTS: Inclusion of 8 cases and 11 controls resulted in 10 case scans (2 cases were included twice) and 33 control scans. In controls, the T1 relaxation time was 1,005-1,391 ms; in cases with severe anemia, 1,505-1,595 ms, moderate anemia 1,503-1,525 ms, and no/mild anemia 1,245-1,410 ms. After blood transfusions, values dropped to 1,123-1,288 ms. The mean value in moderate and severe anemic cases was 275 ms higher than in controls (95% CI 210-341 ms, p < 0.0001), and after blood transfusion it was comparable to controls (3 ms, 95% CI -62 to 68 ms, p = 0.934). A 1,450-ms cut-off would have identified all cases in need of blood transfusion with no false-positive cases.CONCLUSIONS: Our findings indicate a potential for this new MRI method to improve the prediction of fetal anemia as a supplement to ultrasound.

U2 - 10.1159/000494615

DO - 10.1159/000494615

M3 - Journal article

C2 - 30731466

VL - 46

SP - 257

EP - 265

JO - Fetal Diagnosis and Therapy

JF - Fetal Diagnosis and Therapy

SN - 1015-3837

IS - 4

ER -

ID: 217613353