TY - JOUR

T1 - Long-Term Exposure to Transportation Noise and Ischemic Heart Disease

T2 - A Pooled Analysis of Nine Scandinavian Cohorts

AU - Pyko, Andrei

AU - Roswall, Nina

AU - Ögren, Mikael

AU - Oudin, Anna

AU - Rosengren, Annika

AU - Eriksson, Charlotta

AU - Segersson, David

AU - Rizzuto, Debora

AU - Andersson, Eva M

AU - Aasvang, Gunn Marit

AU - Engström, Gunnar

AU - Gudjonsdottir, Hrafnhildur

AU - Jørgensen, Jeanette T

AU - Selander, Jenny

AU - Christensen, Jesper H

AU - Brandt, Jørgen

AU - Leander, Karin

AU - Overvad, Kim

AU - Eneroth, Kristina

AU - Mattisson, Kristoffer

AU - Barregard, Lars

AU - Stockfelt, Leo

AU - Albin, Maria

AU - Simonsen, Mette K

AU - Tiittanen, Pekka

AU - Molnar, Peter

AU - Ljungman, Petter

AU - Solvang Jensen, Steen

AU - Gustafsson, Susanna

AU - Lanki, Timo

AU - Lim, Youn-Hee

AU - Andersen, Zorana J

AU - Sørensen, Mette

AU - Pershagen, Göran

PY - 2023

Y1 - 2023

N2 - BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear.OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes.METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were calculated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors.RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB L den for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB L den for road and railway noise, respectively. Corresponding HRs for myocardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB L den was suggested in the exposure-response relation for road traffic noise and IHD. DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries. https://doi.org/10.1289/EHP10745.

AB - BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear.OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes.METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were calculated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors.RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB L den for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB L den for road and railway noise, respectively. Corresponding HRs for myocardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB L den was suggested in the exposure-response relation for road traffic noise and IHD. DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries. https://doi.org/10.1289/EHP10745.

KW - Humans

KW - Noise, Transportation/adverse effects

KW - Environmental Exposure

KW - Myocardial Ischemia/epidemiology

KW - Myocardial Infarction/epidemiology

KW - Angina Pectoris

U2 - 10.1289/EHP10745

DO - 10.1289/EHP10745

M3 - Journal article

C2 - 36607286

VL - 131

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 1

M1 - 17003

ER -