Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Massimo Stafoggia
  • Gudrun Weinmayr
  • Claudia Galassi
  • Anna Oudin
  • Bertil Forsberg
  • David Olsson
  • Bente Oftedal
  • Gunn Marit Aasvang
  • Geir Aamodt
  • Andrei Pyko
  • Göran Pershagen
  • Michal Korek
  • Ulf De Faire
  • Nancy L Pedersen
  • Claes-Göran Östenson
  • Laura Fratiglioni
  • Kirsten T. Eriksen
  • Petra H Peeters
  • Bas Bueno-de-Mesquita
  • Michelle Plusquin
  • Timothy J Key
  • Andrea Jaensch
  • Gabriele Nagel
  • Alois Lang
  • Meng Wang
  • Ming-Yi Tsai
  • Agnes Fournier
  • Marie-Christine Boutron-Ruault
  • Laura Baglietto
  • Sara Grioni
  • Alessandro Marcon
  • Vittorio Krogh
  • Fulvio Ricceri
  • Carlotta Sacerdote
  • Enrica Migliore
  • Ibon Tamayo-Uria
  • Pilar Amiano
  • Miren Dorronsoro
  • Roel Vermeulen
  • Ranjeet Sokhi
  • Menno Keuken
  • Kees de Hoogh
  • Rob Beelen
  • Paolo Vineis
  • Giulia Cesaroni
  • Bert Brunekreef
  • Gerard Hoek
  • Ole Raaschou-Nielsen

BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.

OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.

METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts – Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2.5μm, ≤10μm, and 2.5–10μm in diameter (PM2.5, PM10, and PMcoarse, respectively); PM2.5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.

RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2.5 {hazard ratio (HR)=1.08 [95% confidence interval (CI): 0.77, 1.51] per 5 μg/m(3)}, PM10 [1.07 (95% CI: 0.89, 1.30) per 10 μg/m(3)], PMcoarse[1.20 (95% CI: 0.96, 1.49 per 5 μg/m(3)], and NO(2) [1.02 (95% CI: 0.98, 1.07 per 10 μg/m(3)], and a statistically significant association with NOx [1.04 (95% CI: 1.00, 1.08) per 20 μg/m(3), p=0.04].

CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women.

OriginalsprogEngelsk
Artikelnummer107005
TidsskriftEnvironmental Health Perspectives
Vol/bind125
Udgave nummer10
Sider (fra-til)1-14
Antal sider14
ISSN0091-6765
DOI
StatusUdgivet - 13 okt. 2017

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