Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution: a Study in Europe (ELAPSE)

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Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution : a Study in Europe (ELAPSE). / Hvidtfeldt, Ulla Arthur; Taj, Tahir; Chen, Jie; Rodopoulou, Sophia; Strak, Maciej; de Hoogh, Kees; Andersen, Zorana J.; Bellander, Tom; Brandt, Jorgen; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Jørgensen, Jeanette T.; Katsouyanni, Klea; Ketzel, Matthias; Lager, Anton; Leander, Karin; Ljungman, Petter; Magnusson, Patrik K. E.; Nagel, Gabriele; Pershagen, Goran; Rizzuto, Debora; Samoli, Evangelia; So, Rina; Stafoggia, Massimo; Tjonneland, Anne; Vermeulen, Roel; Weinmayr, Gudrun; Wolf, Kathrin; Zhang, Jiawei; Zitt, Emanuel; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole.

I: Environmental Research, Bind 215, Nr. Part 2, 114385, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hvidtfeldt, UA, Taj, T, Chen, J, Rodopoulou, S, Strak, M, de Hoogh, K, Andersen, ZJ, Bellander, T, Brandt, J, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, B, Jørgensen, JT, Katsouyanni, K, Ketzel, M, Lager, A, Leander, K, Ljungman, P, Magnusson, PKE, Nagel, G, Pershagen, G, Rizzuto, D, Samoli, E, So, R, Stafoggia, M, Tjonneland, A, Vermeulen, R, Weinmayr, G, Wolf, K, Zhang, J, Zitt, E, Brunekreef, B, Hoek, G & Raaschou-Nielsen, O 2022, 'Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution: a Study in Europe (ELAPSE)', Environmental Research, bind 215, nr. Part 2, 114385. https://doi.org/10.1016/j.envres.2022.114385

APA

Hvidtfeldt, U. A., Taj, T., Chen, J., Rodopoulou, S., Strak, M., de Hoogh, K., Andersen, Z. J., Bellander, T., Brandt, J., Fecht, D., Forastiere, F., Gulliver, J., Hertel, O., Hoffmann, B., Jørgensen, J. T., Katsouyanni, K., Ketzel, M., Lager, A., Leander, K., ... Raaschou-Nielsen, O. (2022). Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution: a Study in Europe (ELAPSE). Environmental Research, 215(Part 2), [114385]. https://doi.org/10.1016/j.envres.2022.114385

Vancouver

Hvidtfeldt UA, Taj T, Chen J, Rodopoulou S, Strak M, de Hoogh K o.a. Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution: a Study in Europe (ELAPSE). Environmental Research. 2022;215(Part 2). 114385. https://doi.org/10.1016/j.envres.2022.114385

Author

Hvidtfeldt, Ulla Arthur ; Taj, Tahir ; Chen, Jie ; Rodopoulou, Sophia ; Strak, Maciej ; de Hoogh, Kees ; Andersen, Zorana J. ; Bellander, Tom ; Brandt, Jorgen ; Fecht, Daniela ; Forastiere, Francesco ; Gulliver, John ; Hertel, Ole ; Hoffmann, Barbara ; Jørgensen, Jeanette T. ; Katsouyanni, Klea ; Ketzel, Matthias ; Lager, Anton ; Leander, Karin ; Ljungman, Petter ; Magnusson, Patrik K. E. ; Nagel, Gabriele ; Pershagen, Goran ; Rizzuto, Debora ; Samoli, Evangelia ; So, Rina ; Stafoggia, Massimo ; Tjonneland, Anne ; Vermeulen, Roel ; Weinmayr, Gudrun ; Wolf, Kathrin ; Zhang, Jiawei ; Zitt, Emanuel ; Brunekreef, Bert ; Hoek, Gerard ; Raaschou-Nielsen, Ole. / Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution : a Study in Europe (ELAPSE). I: Environmental Research. 2022 ; Bind 215, Nr. Part 2.

Bibtex

@article{673f721377754f0fb59afca8cc26facb,
title = "Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution: a Study in Europe (ELAPSE)",
abstract = "BACKGROUND: Particulate matter (PM) is classified as a group 1 human carcinogen. Previous experimental studies suggest that particles in diesel exhaust induce oxidative stress, inflammation and DNA damage in kidney cells, but the evidence from population studies linking air pollution to kidney cancer is limited.METHODS: We pooled six European cohorts (N = 302,493) to assess the association of residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) with cancer of the kidney parenchyma. The main exposure model was developed for year 2010. We defined kidney parenchyma cancer according to the International Classification of Diseases 9th and 10th Revision codes 189.0 and C64. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.RESULTS: The participants were followed from baseline (1985-2005) to 2011-2015. A total of 847 cases occurred during 5,497,514 person-years of follow-up (average 18.2 years). Median (5-95%) exposure levels of NO2, PM2.5, BC and O3 were 24.1 mu g/m3 (12.8-39.2), 15.3 mu g/m3 (8.6-19.2), 1.6 10-5 m-1 (0.7-2.1), and 87.0 mu g/m3 (70.3-97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 mu g/m3 NO2, 1.04 (95% CI: 0.88, 1.21) per 5 mu g/m3 PM2.5, 0.99 (95% CI: 0.89, 1.11) per 0.5 10-5 m-1 BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 mu g/m3 O3. We did not find associations between any of the elemental components of PM2.5 and cancer of the kidney parenchyma.CONCLUSION: We did not observe an association between long-term ambient air pollution exposure and incidence of kidney parenchyma cancer.",
keywords = "air Pollution, Kidney cancer incidence, Nitrogen dioxide, Particulate matter, PM elemental Components, Ozone, RENAL-CELL CARCINOMA, COHORT PROFILE, RISK, MEN, METAANALYSIS, POPULATION, MODELS, HEALTH, WOMEN, PM2.5",
author = "Hvidtfeldt, {Ulla Arthur} and Tahir Taj and Jie Chen and Sophia Rodopoulou and Maciej Strak and {de Hoogh}, Kees and Andersen, {Zorana J.} and Tom Bellander and Jorgen Brandt and Daniela Fecht and Francesco Forastiere and John Gulliver and Ole Hertel and Barbara Hoffmann and J{\o}rgensen, {Jeanette T.} and Klea Katsouyanni and Matthias Ketzel and Anton Lager and Karin Leander and Petter Ljungman and Magnusson, {Patrik K. E.} and Gabriele Nagel and Goran Pershagen and Debora Rizzuto and Evangelia Samoli and Rina So and Massimo Stafoggia and Anne Tjonneland and Roel Vermeulen and Gudrun Weinmayr and Kathrin Wolf and Jiawei Zhang and Emanuel Zitt and Bert Brunekreef and Gerard Hoek and Ole Raaschou-Nielsen",
year = "2022",
doi = "10.1016/j.envres.2022.114385",
language = "English",
volume = "215",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press",
number = "Part 2",

}

RIS

TY - JOUR

T1 - Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution

T2 - a Study in Europe (ELAPSE)

AU - Hvidtfeldt, Ulla Arthur

AU - Taj, Tahir

AU - Chen, Jie

AU - Rodopoulou, Sophia

AU - Strak, Maciej

AU - de Hoogh, Kees

AU - Andersen, Zorana J.

AU - Bellander, Tom

AU - Brandt, Jorgen

AU - Fecht, Daniela

AU - Forastiere, Francesco

AU - Gulliver, John

AU - Hertel, Ole

AU - Hoffmann, Barbara

AU - Jørgensen, Jeanette T.

AU - Katsouyanni, Klea

AU - Ketzel, Matthias

AU - Lager, Anton

AU - Leander, Karin

AU - Ljungman, Petter

AU - Magnusson, Patrik K. E.

AU - Nagel, Gabriele

AU - Pershagen, Goran

AU - Rizzuto, Debora

AU - Samoli, Evangelia

AU - So, Rina

AU - Stafoggia, Massimo

AU - Tjonneland, Anne

AU - Vermeulen, Roel

AU - Weinmayr, Gudrun

AU - Wolf, Kathrin

AU - Zhang, Jiawei

AU - Zitt, Emanuel

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

PY - 2022

Y1 - 2022

N2 - BACKGROUND: Particulate matter (PM) is classified as a group 1 human carcinogen. Previous experimental studies suggest that particles in diesel exhaust induce oxidative stress, inflammation and DNA damage in kidney cells, but the evidence from population studies linking air pollution to kidney cancer is limited.METHODS: We pooled six European cohorts (N = 302,493) to assess the association of residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) with cancer of the kidney parenchyma. The main exposure model was developed for year 2010. We defined kidney parenchyma cancer according to the International Classification of Diseases 9th and 10th Revision codes 189.0 and C64. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.RESULTS: The participants were followed from baseline (1985-2005) to 2011-2015. A total of 847 cases occurred during 5,497,514 person-years of follow-up (average 18.2 years). Median (5-95%) exposure levels of NO2, PM2.5, BC and O3 were 24.1 mu g/m3 (12.8-39.2), 15.3 mu g/m3 (8.6-19.2), 1.6 10-5 m-1 (0.7-2.1), and 87.0 mu g/m3 (70.3-97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 mu g/m3 NO2, 1.04 (95% CI: 0.88, 1.21) per 5 mu g/m3 PM2.5, 0.99 (95% CI: 0.89, 1.11) per 0.5 10-5 m-1 BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 mu g/m3 O3. We did not find associations between any of the elemental components of PM2.5 and cancer of the kidney parenchyma.CONCLUSION: We did not observe an association between long-term ambient air pollution exposure and incidence of kidney parenchyma cancer.

AB - BACKGROUND: Particulate matter (PM) is classified as a group 1 human carcinogen. Previous experimental studies suggest that particles in diesel exhaust induce oxidative stress, inflammation and DNA damage in kidney cells, but the evidence from population studies linking air pollution to kidney cancer is limited.METHODS: We pooled six European cohorts (N = 302,493) to assess the association of residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) with cancer of the kidney parenchyma. The main exposure model was developed for year 2010. We defined kidney parenchyma cancer according to the International Classification of Diseases 9th and 10th Revision codes 189.0 and C64. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.RESULTS: The participants were followed from baseline (1985-2005) to 2011-2015. A total of 847 cases occurred during 5,497,514 person-years of follow-up (average 18.2 years). Median (5-95%) exposure levels of NO2, PM2.5, BC and O3 were 24.1 mu g/m3 (12.8-39.2), 15.3 mu g/m3 (8.6-19.2), 1.6 10-5 m-1 (0.7-2.1), and 87.0 mu g/m3 (70.3-97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 mu g/m3 NO2, 1.04 (95% CI: 0.88, 1.21) per 5 mu g/m3 PM2.5, 0.99 (95% CI: 0.89, 1.11) per 0.5 10-5 m-1 BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 mu g/m3 O3. We did not find associations between any of the elemental components of PM2.5 and cancer of the kidney parenchyma.CONCLUSION: We did not observe an association between long-term ambient air pollution exposure and incidence of kidney parenchyma cancer.

KW - air Pollution

KW - Kidney cancer incidence

KW - Nitrogen dioxide

KW - Particulate matter

KW - PM elemental Components

KW - Ozone

KW - RENAL-CELL CARCINOMA

KW - COHORT PROFILE

KW - RISK

KW - MEN

KW - METAANALYSIS

KW - POPULATION

KW - MODELS

KW - HEALTH

KW - WOMEN

KW - PM2.5

U2 - 10.1016/j.envres.2022.114385

DO - 10.1016/j.envres.2022.114385

M3 - Journal article

C2 - 36154858

VL - 215

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

IS - Part 2

M1 - 114385

ER -

ID: 325671116