Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution: a Study in Europe (ELAPSE)
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Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution : a Study in Europe (ELAPSE). / Hvidtfeldt, Ulla Arthur; Taj, Tahir; Chen, Jie; Rodopoulou, Sophia; Strak, Maciej; de Hoogh, Kees; Andersen, Zorana J.; Bellander, Tom; Brandt, Jorgen; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Jørgensen, Jeanette T.; Katsouyanni, Klea; Ketzel, Matthias; Lager, Anton; Leander, Karin; Ljungman, Petter; Magnusson, Patrik K. E.; Nagel, Gabriele; Pershagen, Goran; Rizzuto, Debora; Samoli, Evangelia; So, Rina; Stafoggia, Massimo; Tjonneland, Anne; Vermeulen, Roel; Weinmayr, Gudrun; Wolf, Kathrin; Zhang, Jiawei; Zitt, Emanuel; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole.
I: Environmental Research, Bind 215, Nr. Part 2, 114385, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Long term exposure to air pollution and kidney parenchyma cancer - Effects of low-level air pollution
T2 - a Study in Europe (ELAPSE)
AU - Hvidtfeldt, Ulla Arthur
AU - Taj, Tahir
AU - Chen, Jie
AU - Rodopoulou, Sophia
AU - Strak, Maciej
AU - de Hoogh, Kees
AU - Andersen, Zorana J.
AU - Bellander, Tom
AU - Brandt, Jorgen
AU - Fecht, Daniela
AU - Forastiere, Francesco
AU - Gulliver, John
AU - Hertel, Ole
AU - Hoffmann, Barbara
AU - Jørgensen, Jeanette T.
AU - Katsouyanni, Klea
AU - Ketzel, Matthias
AU - Lager, Anton
AU - Leander, Karin
AU - Ljungman, Petter
AU - Magnusson, Patrik K. E.
AU - Nagel, Gabriele
AU - Pershagen, Goran
AU - Rizzuto, Debora
AU - Samoli, Evangelia
AU - So, Rina
AU - Stafoggia, Massimo
AU - Tjonneland, Anne
AU - Vermeulen, Roel
AU - Weinmayr, Gudrun
AU - Wolf, Kathrin
AU - Zhang, Jiawei
AU - Zitt, Emanuel
AU - Brunekreef, Bert
AU - Hoek, Gerard
AU - Raaschou-Nielsen, Ole
PY - 2022
Y1 - 2022
N2 - BACKGROUND: Particulate matter (PM) is classified as a group 1 human carcinogen. Previous experimental studies suggest that particles in diesel exhaust induce oxidative stress, inflammation and DNA damage in kidney cells, but the evidence from population studies linking air pollution to kidney cancer is limited.METHODS: We pooled six European cohorts (N = 302,493) to assess the association of residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) with cancer of the kidney parenchyma. The main exposure model was developed for year 2010. We defined kidney parenchyma cancer according to the International Classification of Diseases 9th and 10th Revision codes 189.0 and C64. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.RESULTS: The participants were followed from baseline (1985-2005) to 2011-2015. A total of 847 cases occurred during 5,497,514 person-years of follow-up (average 18.2 years). Median (5-95%) exposure levels of NO2, PM2.5, BC and O3 were 24.1 mu g/m3 (12.8-39.2), 15.3 mu g/m3 (8.6-19.2), 1.6 10-5 m-1 (0.7-2.1), and 87.0 mu g/m3 (70.3-97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 mu g/m3 NO2, 1.04 (95% CI: 0.88, 1.21) per 5 mu g/m3 PM2.5, 0.99 (95% CI: 0.89, 1.11) per 0.5 10-5 m-1 BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 mu g/m3 O3. We did not find associations between any of the elemental components of PM2.5 and cancer of the kidney parenchyma.CONCLUSION: We did not observe an association between long-term ambient air pollution exposure and incidence of kidney parenchyma cancer.
AB - BACKGROUND: Particulate matter (PM) is classified as a group 1 human carcinogen. Previous experimental studies suggest that particles in diesel exhaust induce oxidative stress, inflammation and DNA damage in kidney cells, but the evidence from population studies linking air pollution to kidney cancer is limited.METHODS: We pooled six European cohorts (N = 302,493) to assess the association of residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) with cancer of the kidney parenchyma. The main exposure model was developed for year 2010. We defined kidney parenchyma cancer according to the International Classification of Diseases 9th and 10th Revision codes 189.0 and C64. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.RESULTS: The participants were followed from baseline (1985-2005) to 2011-2015. A total of 847 cases occurred during 5,497,514 person-years of follow-up (average 18.2 years). Median (5-95%) exposure levels of NO2, PM2.5, BC and O3 were 24.1 mu g/m3 (12.8-39.2), 15.3 mu g/m3 (8.6-19.2), 1.6 10-5 m-1 (0.7-2.1), and 87.0 mu g/m3 (70.3-97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 mu g/m3 NO2, 1.04 (95% CI: 0.88, 1.21) per 5 mu g/m3 PM2.5, 0.99 (95% CI: 0.89, 1.11) per 0.5 10-5 m-1 BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 mu g/m3 O3. We did not find associations between any of the elemental components of PM2.5 and cancer of the kidney parenchyma.CONCLUSION: We did not observe an association between long-term ambient air pollution exposure and incidence of kidney parenchyma cancer.
KW - air Pollution
KW - Kidney cancer incidence
KW - Nitrogen dioxide
KW - Particulate matter
KW - PM elemental Components
KW - Ozone
KW - RENAL-CELL CARCINOMA
KW - COHORT PROFILE
KW - RISK
KW - MEN
KW - METAANALYSIS
KW - POPULATION
KW - MODELS
KW - HEALTH
KW - WOMEN
KW - PM2.5
U2 - 10.1016/j.envres.2022.114385
DO - 10.1016/j.envres.2022.114385
M3 - Journal article
C2 - 36154858
VL - 215
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
IS - Part 2
M1 - 114385
ER -
ID: 325671116