Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans

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Standard

Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans. / Hansen, M; Boesen, A; Holm, L; Flyvbjerg, A; Langberg, H.; Kjær, Michael.

I: Scandinavian Journal of Medicine & Science in Sports, Bind 23, Nr. 5, 2013, s. 614-619.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Hansen, M, Boesen, A, Holm, L, Flyvbjerg, A, Langberg, H & Kjær, M 2013, 'Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans', Scandinavian Journal of Medicine & Science in Sports, bind 23, nr. 5, s. 614-619. https://doi.org/10.1111/j.1600-0838.2011.01431.x

APA

Hansen, M., Boesen, A., Holm, L., Flyvbjerg, A., Langberg, H., & Kjær, M. (2013). Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans. Scandinavian Journal of Medicine & Science in Sports, 23(5), 614-619. https://doi.org/10.1111/j.1600-0838.2011.01431.x

Vancouver

Hansen M, Boesen A, Holm L, Flyvbjerg A, Langberg H, Kjær M. Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans. Scandinavian Journal of Medicine & Science in Sports. 2013;23(5):614-619. https://doi.org/10.1111/j.1600-0838.2011.01431.x

Author

Hansen, M ; Boesen, A ; Holm, L ; Flyvbjerg, A ; Langberg, H. ; Kjær, Michael. / Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans. I: Scandinavian Journal of Medicine & Science in Sports. 2013 ; Bind 23, Nr. 5. s. 614-619.

Bibtex

@article{bf22e35646bd4077804ff155d2e73855,
title = "Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans",
abstract = "Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62¿±¿1¿years (mean¿±¿SEM), BMI 27¿±¿1] participated. Two injections of either human recombinant IGF-I (0.1¿mL Increlex{\textcopyright}) or saline (control) into each patellar tendon were performed 24-h apart, respectively. Tendon collagen fractional synthesis rate (FSR) was measured by stable isotope technique in the hours after the second injection. Simultaneously, interstitial peritendinous (IGF-I) and [procollagen type I N-terminal propeptide (PINP)], as a marker for type I collagen synthesis, were determined by microdialysis technique. Tendon collagen FSR and PINP were significantly higher in the IGF-I leg compared with the control leg (P¿",
author = "M Hansen and A Boesen and L Holm and A Flyvbjerg and H. Langberg and Michael Kj{\ae}r",
note = "{\textcopyright} 2012 John Wiley & Sons A/S.",
year = "2013",
doi = "10.1111/j.1600-0838.2011.01431.x",
language = "English",
volume = "23",
pages = "614--619",
journal = "Scandinavian Journal of Medicine & Science in Sports",
issn = "0905-7188",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans

AU - Hansen, M

AU - Boesen, A

AU - Holm, L

AU - Flyvbjerg, A

AU - Langberg, H.

AU - Kjær, Michael

N1 - © 2012 John Wiley & Sons A/S.

PY - 2013

Y1 - 2013

N2 - Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62¿±¿1¿years (mean¿±¿SEM), BMI 27¿±¿1] participated. Two injections of either human recombinant IGF-I (0.1¿mL Increlex©) or saline (control) into each patellar tendon were performed 24-h apart, respectively. Tendon collagen fractional synthesis rate (FSR) was measured by stable isotope technique in the hours after the second injection. Simultaneously, interstitial peritendinous (IGF-I) and [procollagen type I N-terminal propeptide (PINP)], as a marker for type I collagen synthesis, were determined by microdialysis technique. Tendon collagen FSR and PINP were significantly higher in the IGF-I leg compared with the control leg (P¿

AB - Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62¿±¿1¿years (mean¿±¿SEM), BMI 27¿±¿1] participated. Two injections of either human recombinant IGF-I (0.1¿mL Increlex©) or saline (control) into each patellar tendon were performed 24-h apart, respectively. Tendon collagen fractional synthesis rate (FSR) was measured by stable isotope technique in the hours after the second injection. Simultaneously, interstitial peritendinous (IGF-I) and [procollagen type I N-terminal propeptide (PINP)], as a marker for type I collagen synthesis, were determined by microdialysis technique. Tendon collagen FSR and PINP were significantly higher in the IGF-I leg compared with the control leg (P¿

U2 - 10.1111/j.1600-0838.2011.01431.x

DO - 10.1111/j.1600-0838.2011.01431.x

M3 - Journal article

C2 - 22288768

VL - 23

SP - 614

EP - 619

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

SN - 0905-7188

IS - 5

ER -

ID: 122548230