Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans
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Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans. / Hansen, M; Boesen, A; Holm, L; Flyvbjerg, A; Langberg, H.; Kjær, Michael.
I: Scandinavian Journal of Medicine & Science in Sports, Bind 23, Nr. 5, 2013, s. 614-619.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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T1 - Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans
AU - Hansen, M
AU - Boesen, A
AU - Holm, L
AU - Flyvbjerg, A
AU - Langberg, H.
AU - Kjær, Michael
N1 - © 2012 John Wiley & Sons A/S.
PY - 2013
Y1 - 2013
N2 - Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62¿±¿1¿years (mean¿±¿SEM), BMI 27¿±¿1] participated. Two injections of either human recombinant IGF-I (0.1¿mL Increlex©) or saline (control) into each patellar tendon were performed 24-h apart, respectively. Tendon collagen fractional synthesis rate (FSR) was measured by stable isotope technique in the hours after the second injection. Simultaneously, interstitial peritendinous (IGF-I) and [procollagen type I N-terminal propeptide (PINP)], as a marker for type I collagen synthesis, were determined by microdialysis technique. Tendon collagen FSR and PINP were significantly higher in the IGF-I leg compared with the control leg (P¿
AB - Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62¿±¿1¿years (mean¿±¿SEM), BMI 27¿±¿1] participated. Two injections of either human recombinant IGF-I (0.1¿mL Increlex©) or saline (control) into each patellar tendon were performed 24-h apart, respectively. Tendon collagen fractional synthesis rate (FSR) was measured by stable isotope technique in the hours after the second injection. Simultaneously, interstitial peritendinous (IGF-I) and [procollagen type I N-terminal propeptide (PINP)], as a marker for type I collagen synthesis, were determined by microdialysis technique. Tendon collagen FSR and PINP were significantly higher in the IGF-I leg compared with the control leg (P¿
U2 - 10.1111/j.1600-0838.2011.01431.x
DO - 10.1111/j.1600-0838.2011.01431.x
M3 - Journal article
C2 - 22288768
VL - 23
SP - 614
EP - 619
JO - Scandinavian Journal of Medicine & Science in Sports
JF - Scandinavian Journal of Medicine & Science in Sports
SN - 0905-7188
IS - 5
ER -
ID: 122548230