Lactation Duration and Long-Term Thyroid Function: A Study among Women with Gestational Diabetes
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Lactation Duration and Long-Term Thyroid Function : A Study among Women with Gestational Diabetes. / Panuganti, Pranati L; Hinkle, Stefanie N; Rawal, Shristi; Grunnet, Louise G; Lin, Yuan; Liu, Aiyi; Thuesen, Anne C B; Ley, Sylvia H; Olesen, Sjurdur F; Zhang, Cuilin.
I: Nutrients, Bind 10, Nr. 7, 938, 21.07.2018.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Lactation Duration and Long-Term Thyroid Function
T2 - A Study among Women with Gestational Diabetes
AU - Panuganti, Pranati L
AU - Hinkle, Stefanie N
AU - Rawal, Shristi
AU - Grunnet, Louise G
AU - Lin, Yuan
AU - Liu, Aiyi
AU - Thuesen, Anne C B
AU - Ley, Sylvia H
AU - Olesen, Sjurdur F
AU - Zhang, Cuilin
PY - 2018/7/21
Y1 - 2018/7/21
N2 - Lactation is associated with reduced postpartum weight retention and a lower risk of several cardiometabolic disorders in population-based studies. We examined the association between lactation and long-term thyroid function among women with history of gestational diabetes mellitus (GDM), a high-risk population for subsequent metabolic complications. The study included 550 women who developed GDM in the Danish National Birth Cohort (1996⁻2002) and followed-up in the Diabetes & Women's Health Study (2012⁻2014). We assessed adjusted associations between cumulative lactation duration and concentrations of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) measured at follow-up. Women with longer cumulative lactation duration tended to have higher fT3 levels (adjusted β and 95% confidence interval (CI) for ≥12 months vs. none: 0.19 (0.03⁻0.36); p-trend = 0.05). When restricted to women with a single lifetime pregnancy to control for parity (n = 70), women who lactated for >6 months (vs. none) had higher fT3 levels (0.46 pmol/L (0.12⁻0.80); p-trend = 0.02) and a higher fT3:fT4 ratio (0.61 (0.17⁻1.05); p-trend = 0.007). Our findings suggested that a longer duration of lactation may be related to greater serum fT3 levels and fT3:fT4 ratio 9⁻16 years postpartum among Danish women with a history of GDM. The association was particularly pronounced among women who only had one lifetime pregnancy.
AB - Lactation is associated with reduced postpartum weight retention and a lower risk of several cardiometabolic disorders in population-based studies. We examined the association between lactation and long-term thyroid function among women with history of gestational diabetes mellitus (GDM), a high-risk population for subsequent metabolic complications. The study included 550 women who developed GDM in the Danish National Birth Cohort (1996⁻2002) and followed-up in the Diabetes & Women's Health Study (2012⁻2014). We assessed adjusted associations between cumulative lactation duration and concentrations of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) measured at follow-up. Women with longer cumulative lactation duration tended to have higher fT3 levels (adjusted β and 95% confidence interval (CI) for ≥12 months vs. none: 0.19 (0.03⁻0.36); p-trend = 0.05). When restricted to women with a single lifetime pregnancy to control for parity (n = 70), women who lactated for >6 months (vs. none) had higher fT3 levels (0.46 pmol/L (0.12⁻0.80); p-trend = 0.02) and a higher fT3:fT4 ratio (0.61 (0.17⁻1.05); p-trend = 0.007). Our findings suggested that a longer duration of lactation may be related to greater serum fT3 levels and fT3:fT4 ratio 9⁻16 years postpartum among Danish women with a history of GDM. The association was particularly pronounced among women who only had one lifetime pregnancy.
KW - Adult
KW - Antibodies/blood
KW - Biomarkers
KW - Cohort Studies
KW - Diabetes, Gestational
KW - Female
KW - Humans
KW - Hyperthyroidism
KW - Hypothyroidism/blood
KW - Iodide Peroxidase/immunology
KW - Lactation/physiology
KW - Pregnancy
KW - Risk Factors
KW - Thyroid Gland/physiology
KW - Thyroxine/blood
KW - Time Factors
KW - Women's Health
U2 - 10.3390/nu10070938
DO - 10.3390/nu10070938
M3 - Journal article
C2 - 30037073
VL - 10
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 7
M1 - 938
ER -
ID: 210923708