Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Studies of the resting brain measurements of cerebral blood flow (CBF) show large interindividual and regional variability, but the metabolic basis of this variability is not fully established. The aim of the present study was to reassess regional and interindividual relationship between cerebral perfusion and glucose metabolism in the resting brain. Regional quantitative measurements of CBF and cerebral metabolic rate of glucose (CMRglc) were obtained in 24 healthy young males using dynamic 15O-H2O and 18F-fluoro-deoxyglucose positron emission tomography (PET). Magnetic resonance imaging measurements of global oxygen extraction fraction (gOEF) and metabolic rate of oxygen (gCMRO2) were obtained by combined susceptometry based sagittal sinus oximetry and phase contrast mapping. No significant interindividual associations between global CBF, global CMRglc and gCMRO2 were observed. Linear mixed model analysis showed a highly significant association of CBF with CMRglc regionally. Compared to neocortex significantly higher CBF values than explained by CMRglc were demonstrated in infratentorial structures, thalami and mesial temporal cortex, and lower values were found in the striatum and cerebral white matter. The present study shows that absolute quantitative global CBF measurements appear not to be a valid surrogate measure of global cerebral glucose or oxygen consumption, and further demonstrates regionally variable relationship between perfusion and glucose metabolism in the resting brain that could suggest regional differences in energy substrate metabolism.
|Tidsskrift||Journal of Applied Physiology|
|Status||Udgivet - 2018|