TY - JOUR

T1 - Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain

AU - Henriksen, Otto M.

AU - Vestergaard, Mark Bitsch

AU - Lindberg, Ulrich

AU - Aachmann-Andersen, Niels Jacob

AU - Lisbjerg, Kristian

AU - Christensen, Søren Just

AU - Rasmussen, Peter

AU - Olsen, Niels Vidiendal

AU - Forman, Julie L.

AU - Larsson, Henrik Bo Wiberg

AU - Law, Ian

PY - 2018

Y1 - 2018

N2 - Studies of the resting brain measurements of cerebral blood flow (CBF) show large interindividual and regional variability, but the metabolic basis of this variability is not fully established. The aim of the present study was to reassess regional and interindividual relationship between cerebral perfusion and glucose metabolism in the resting brain. Regional quantitative measurements of CBF and cerebral metabolic rate of glucose (CMRglc) were obtained in 24 healthy young males using dynamic 15O-H2O and 18F-fluoro-deoxyglucose positron emission tomography (PET). Magnetic resonance imaging measurements of global oxygen extraction fraction (gOEF) and metabolic rate of oxygen (gCMRO2) were obtained by combined susceptometry based sagittal sinus oximetry and phase contrast mapping. No significant interindividual associations between global CBF, global CMRglc and gCMRO2 were observed. Linear mixed model analysis showed a highly significant association of CBF with CMRglc regionally. Compared to neocortex significantly higher CBF values than explained by CMRglc were demonstrated in infratentorial structures, thalami and mesial temporal cortex, and lower values were found in the striatum and cerebral white matter. The present study shows that absolute quantitative global CBF measurements appear not to be a valid surrogate measure of global cerebral glucose or oxygen consumption, and further demonstrates regionally variable relationship between perfusion and glucose metabolism in the resting brain that could suggest regional differences in energy substrate metabolism.

AB - Studies of the resting brain measurements of cerebral blood flow (CBF) show large interindividual and regional variability, but the metabolic basis of this variability is not fully established. The aim of the present study was to reassess regional and interindividual relationship between cerebral perfusion and glucose metabolism in the resting brain. Regional quantitative measurements of CBF and cerebral metabolic rate of glucose (CMRglc) were obtained in 24 healthy young males using dynamic 15O-H2O and 18F-fluoro-deoxyglucose positron emission tomography (PET). Magnetic resonance imaging measurements of global oxygen extraction fraction (gOEF) and metabolic rate of oxygen (gCMRO2) were obtained by combined susceptometry based sagittal sinus oximetry and phase contrast mapping. No significant interindividual associations between global CBF, global CMRglc and gCMRO2 were observed. Linear mixed model analysis showed a highly significant association of CBF with CMRglc regionally. Compared to neocortex significantly higher CBF values than explained by CMRglc were demonstrated in infratentorial structures, thalami and mesial temporal cortex, and lower values were found in the striatum and cerebral white matter. The present study shows that absolute quantitative global CBF measurements appear not to be a valid surrogate measure of global cerebral glucose or oxygen consumption, and further demonstrates regionally variable relationship between perfusion and glucose metabolism in the resting brain that could suggest regional differences in energy substrate metabolism.

U2 - 10.1152/japplphysiol.00276.2018

DO - 10.1152/japplphysiol.00276.2018

M3 - Journal article

C2 - 29975605

VL - 125

SP - 1080

EP - 1089

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

ER -